Lysosomes / Edition 1

by Eric Holtzman

Overview

In 1976 I wrote a monograph on lysosomes (Lysosomes: A Survey, Springer­ Verlag, Vienna) that was intended as an up-to-date, comprehensive survey. Whatever success I may have achieved then in fulfilling that intention, even the effort now would be foolhardy. The literature has grown so rapidly in the past decade that I certainly could not even read all of the essential papers, let alone understand and analyze them. My goal here, therefore, is simply to introduce the major features of lysosomes at a level I hope will be useful both to I;ldvanced students and to researchers interested in obtaining a broad background. This is in keeping with the design of the Cellular Organelles series: the series is more a set of advanced texts than of review monographs. This design carries with it the decision not to support each point by refer­ ences to the original literature. I apologize for the injustice involved in such a decision but feel that in any event it would be impossibly unwieldy to cite, adequately and in a balanced manner, the contributions of the vast network of researchers responsible for the information upon which I draw.

Product Details

ISBN-13:	9780306431265
Publisher:	Springer US
Publication date:	01/31/1989
Series:	Cellular Organelles
Edition description:	Softcover reprint of the original 1st ed. 1989
Pages:	440
Product dimensions:	7.01(w) x 10.00(h) x 0.24(d)

Table of Contents

1 Historical Fragments; Methods; Some Terminology.- 2 Endocytosis and Heterophagy.- 3 Acidification; Membrane Properties; Permeability and Transport.- 4 Uses and Abuses of Endocytotic and Heterophagic Pathways.- 5 Autophagy and Related Phenomena.- 6 Extensive Release. Excessive Storage.- 7 Genesis.

Editorial Reviews

Covers the chief features of lysosomes at a useful level for students and researchers. Introduces fundamental concepts and terminology, presents historical perspective on the field, discusses heterophagy and autophagy, and reviews lysosome biogenesis. Annotation c. Book News, Inc., Portland, OR (booknews.com)

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