Users' Guides to the Medical Literature: Essentials of Evidence-Based Clinical Practice, Third Edition / Edition 3

by Gordon Guyatt

Overview

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The streamlined companion to the classic Users' Guides to the Medical Literature—fully updated and revised

This compact guide condenses the most clinicallyrelevant content of the landmark Users' Guides to the Medical Literature to help you incorporate evidence-based medicine into your practice.

You will learn the principles of evidence-based medicine, how your practice can benefit from the constant stream of new medical literature, and how to differentiate good medical evidence from that which is inadequate or misleading.

This edition includes numerous updates, several newchapters, and a greater emphasis on the role of patientpreferences and preappraised resources.

Product Details

ISBN-13:	9780071794152
Publisher:	McGraw Hill LLC
Publication date:	01/05/2015
Edition description:	List
Pages:	544
Product dimensions:	4.50(w) x 6.90(h) x 0.90(d)

About the Author

Gordon Guyatt, MD, MSc (Hamilton, Ontario, Canada) Department of Clinical Epidemology and Biostatistics and Medicine, Faculty of Health Services, McMaster University.
Drummond Rennie, MD (Chicago, IL) Philip R. Lee Institute for Health Policy Studies, University of California, San Francisco.
Maureen O. Meade, MD, FRCPC, MSc (Hamilton, Ontario, Canada) Department of Clinical Epidemology and Biostatistics and Medicine, Faculty of Health Services, McMaster University.
Deborah J. Cook, MD, MSc (Hamilton, Ontario, Canada) Department of Clinical Epidemology and Biostatistics and Medicine, Faculty of Health Services, McMaster University.

Table of Contents

Contributors xi

Foreword xvii

Preface xxiii

The Foundations

1 How to Use the Medical Literature-and This Book-to Improve Your Patient Care 1

2 What Is Evidence-Based Medicine? 9

3 What Is the Question? 25

4 Finding Current Best Evidence 43

5 Why Study Results Mislead: Bias and Random Error 85

Therapy

6 Therapy (Randomized Trials) 95

7 How to Use a Noninferiority Trial 127

8 Does Treatment Lower Risk? Understanding the Results 149

9 Confidence Intervals: Was the Single Study or Meta-analysis Large Enough? 165

Harm (Observational Studies)

10 Harm (Observational Studies) 179

Diagnosis

11 The Process of Diagnosis 211

12 Diagnostic Tests 223

Prognosis

13 Prognosis 251

Summarizing the Evidence

14 The Process of a Systematic Review and Meta-analysis 269

15 Understanding and Applying the Results of a Systematic Review and Meta-analysis 291

16 Network Meta-analysis 327

Moving From Evidence to Action

17 How to Use a Patient Management Recommendation: Clinical Practice Guidelines and Decision Analyses 357

18 Decision Making and the Patient 389

Glossary 417

Index 493