The Tao of Chemistry and Life: A Scientific Journey

by Eugene H. Cordes

Overview

Written with the non-scientist in mind, this book employs the molecule and its interactions to explain the characteristics of living organisms in terms of the underlying chemistry of life. Following introductory chapters on the fundamentals of life, attention then turns to small molecules such as hormones and neurotransmitters and subsequently to macromolecules including proteins and nucleic acids. The interactions between small and macromolecules remains a central point throughout the book. These include enzymatic catalysis, hormone action, neurotransmission, regulation of metabolism, biosynthesis of macromolecules, the mechanism of action of drugs, taste, olfaction, learning and memory, and chemical communication.

A second central point of emphasis is the sensitive relationship between chemical structure and biological activity. Examples abound and include why subtle changes in fatty acid architecture have positive or negative outcomes for human health in omega-three fatty acids and trans fats and how modest changes in the chemical decoration of the steroid skeleton provide the difference between male and female sex hormones. Beyond these examples taken from the chemistry of small molecules, the book includes a thoughtful consideration of genomics, including the relationship between genome structure and species. The theme of human health appears throughout the book. Cardiovascular medicine, cancer, metabolic diseases, and diseases of the nervous system receive significant attention including consideration of how a variety of drugs work in combating these issues.

In sum, the goal of this book is to inform the non-scientist community in a way that will lead to increased understanding of the relationship between chemistry and life.

Product Details

ISBN-13:	9780195369632
Publisher:	Oxford University Press
Publication date:	06/04/2009
Pages:	432
Product dimensions:	6.40(w) x 9.30(h) x 1.30(d)

About the Author

Gene Cordes has been a professor of chemistry and pharmacy at Indiana University and the University of Michigan, a VP in the Merck Research Labs and President of R&D at Sterling Winthrop Inc. His research work has been largely in the area of enzymatic and non-enzymatic mechanisms of catalysis whereas his pharmaceutical industry work focused on drug discovery with emphasis on cardiovascular medicine, metabolic diseases, and diagnostic imaging agents.

Books by same author (title, Mahler and Cordes, Biochemistry, Harper and Row, 1966; 2nd edition, 1971, cloth. Mahler and Cordes, Basic Biochemistry, Harper and Row, 1968, cloth. Cordes and Schaeffer, Chemistry, Harper and Row, 1973, cloth.

Table of Contents

1. Life: Unity out of Diversity2. Life: Central Properties3. Molecular Structures Based on Carbon: The Foundation for the Molecules of Life4. Building Blocks and Glue5. From Methane to Chemical Communication6. Nitrogen and Oxygen: Atmospheric Elements7. More About Oxygen-Containing Molecules8. Now for the Rest of the Elements in Vitamin Pills9. Proteins: An Amazing Collection of Multifunctional Molecules10. Amino Acids: The Building Blocks of Proteins11. Proteins Are Three-dimensional Objects12. Nucleotides Are the Building Blocks of Nucleic Acids: The Stuff of Genes13. The Central Dogma of Biology and Protein Synthesis14. Genomes15. Vitamins: Molecules of Life16. Carbohydrates: Sweetness and Life17. Generating Energy from Catabolism18. Fatty Acids: The Building Blocks of Lipids19. Lipids: The Greasy Stuff of Life20. Steroids: Sex and Other Good Things21. Your Brain: What It Does And How It Works22. Your Brain: Good Things and Not-Good Things23. Antibiotics: The Never-Ending War Against Infectious Disease.24. Cancer: What It Is and What We Can Do About It25. Chemical Communication

Editorial Reviews

"A biochemical counterpart to Bill Bryson's A Short History of Nearly Everything. Cordes does essentialy for molecular life science what Bryson did for cosmology, earth and planetary science, and the origin and evolution of life, and he succeeds in his own goal just about as well. This book is eminently readable, with numerous illustrative anecdotes and figures of speech that liven the presentation."—Biochemistry and Molecular Biology Education

"The tone is conversational, and ideas are often conveyed using clever and original analogies, personal anecdotes, and homey expressions." — The Quarterly Review of Biology

From the Publisher