Table of Contents
Dedication. Contents. List of Contributors. Foreword by Otto Götze. Preface; J. Szebeni. The Complement System: Novel Roles in Health and Disease. Part 1: A Piece of Complement History. The Development of the 'One-Hit' or 'Single Site' Theory of Complement Mediated Immune Hemolysis. A personal account; T. Borsos. Part 2: Pathways, Genetics and Gene Regulation of Complement. The initiation complexes of the classical and lectin pathways; P. Gál, G. Ambrus, Zs. Lorincz, P. Závodszky . Complement genetics; Gy. Ábel, V. Agnello. Regulation of complement receptor gene expression: Regulators and inhibitors; M. Tolnay, G.C. Tsokos. Part 3: Novel Regulatory Roles of Complement in Health and Disease. Coordination of adaptive immune responses by C3; A. Erdei, E. Molnár, E. Csomor, Zs. Bajtay, J. Prechl. Terminal complement complex: regulation of formation and pathophysiological functions; F. Tedesco, R. Bulla, F. Fischetti. The many faces of the membrane regulators of complement; C.L. Harris, B.P. Morgan . New insights in the function of decay accelerating factor; L. Kuttner-Kondo, M.E. Medof. The role of complement in pregnancy and fetal loss; G. Girardi, J.E. Salmon. Complement deficiencies: a 2004 update; Gy. Ábel, V. Agnello. Part 4: Exploitation of Complement Proteins in Infection and Cancer. Microbial evasion mechanisms against human complement ; R. Würzner P.F. Zipfel. Complement-mediated antibody-dependent enhancement of viral infections; Z. Prohászka, F.D. Tóth, D. Bánhegyi, G. Füst. Tumor cell resistance to complement-mediated lysis; M. Kirschfink, Z. Fishelson. Part 5: Role of complement in AutoimmuneDiseases, Allergy and Transplantation. Complement and autoimmunity; G.C. Tsokos, M. Tolnay. The complex roles of anaphylatoxins in allergic asthma and autoimmune diseases; H. Hawlisch, M. Wills-Karp, C.L. Karp, J. Köhl. Role of complement in allergy; L. Varga, H. Farkas, G. Füst. Complement activation-related pseudoallergy: Mechanism of anaphylactoid reactions to drug carriers and radiocontrast agents; J. Szebeni. The Role of Complement in Transplantation; M. Kirschfink, T.E. Mollnes. Part 6: Role of Complement in Severe Acute Illnesses. Role of complement in myocardial ischemia and infarction; M.C. Walsh, M.L. Hart, T.M. Bourcier, D. Bhole, M. Takahashi, G.L. Stahl. Role of complement in intestinal ischemia/reperfusion induced injury; S.D. Fleming, G. Tsokos. Role of C5a and C5a receptor in sepsis; F.S. Zetoune, P.A. Ward, M.S. Huber-Lang. Role of complement in multi-organ dysfunction syndrome; M.S. Huber-Lang, J.V. Sarma, F.S. Zetoune, P.A. Ward. Part 7: The Complement System as Therapeutical Target. Therapeutic manipulation of the complement system; T.E. Mollnes. Activation and inhibition of complement by immunoglobulins; M. Basta. Engineering control of complement inhibition at the cell surface; R.A.G. Smith, D. Esser, S.H. Ridley, R. Bradford. Index.