The Cell Cycle in the Central Nervous System / Edition 1

by Damir Janigro

Overview

Cell Cycle in the Central Nervous System overviews the changes in cell cycle as they relate to prenatal and post natal brain development, progression to neurological disease or tumor formation.Topics covered range from the cell cycle during the prenatal development of the mammalian central nervous system to future directions in postnatal neurogenesis through gene transfer, electrical stimulation, and stem cell introduction. Additional chapters examine the postnatal development of neurons and glia, the regulation of cell cycle in glia, and how that regulation may fail in pretumor conditions or following a nonneoplastic CNS response to injury. Highlights include treatments of the effects of deep brain stimulation on brain development and repair; the connection between the electrophysiological properties of neuroglia, cell cycle, and tumor progression; and the varied immunological responses and their regulation by cell cycle.

Product Details

ISBN-13:	9781588295293
Publisher:	Springer-Verlag New York, LLC
Publication date:	03/01/2006
Series:	Contemporary Neuroscience
Edition description:	2006
Pages:	563
Product dimensions:	7.01(w) x 10.00(h) x 0.28(d)

Table of Contents

Cell Cycle During the Development of the Mammalian Central Nervous System.- Methodological Considerations in the Evaluation of the Cell Cycle in the Central Nervous System.- Neural Stem Cells.- Progenitors and Precursors of Neurons and Glial Cells.- Vasculogenesis and Angiogenesis.- Neuronal Migration and Malformations of Cortical Development.- Postnatal Development of Neurons and Glia.- Genome-Wide Expression Profiling of Neurogenesis in Relation to Cell Cycle Exit.- Neurogenesis and Apoptotic Cell Death.- Ion Channels and the Cell Cycle.- Nonsynaptic GABAergic Communication and Postnatal Neurogenesis.- Critical Roles of Ca2+ and K+ Homeostasis in Apoptosis.- Mammalian Neural Stem Cell Renewal.- Control of the Cell Cycle and Apoptosis in Glia.- Methods of Determining Apoptosis in Neuro-Oncology.- Cell Cycle, Neurological Disorders, and Reactive Gliosis.- Potassium Channels, Cell Cycle, and Tumorigenesis in the Central Nervous System.- Adult Neurogenesis: A Mechanism for Brain Repair?.- Enhanced Neurogenesis Following Neurological Disease.- Endothelial Injury and Cell Cycle Re-Entry.- The Contribution of Bone Marrow-Derived Cells to Cerebrovascular Formation and Integrity.- Microvessel Remodeling in Cerebral Ischemia.- Vascular and Neuronal Effects of VEGF in the Nervous System.- Epidermal Growth Factor Receptor in the Adult Brain.- Cell Cycle Re-Entry: A Mechanism of Brain Disease?.- Neurodegeneration and Loss of Cell Cycle Control in Postmitotic Neurons.- Cell Cycle Activation and the Amyloid-? Protein in Alzheimer’s Disease.- Neuronal Precursor Proliferation and Epileptic Malformations of Cortical Development.- Vascular Differentiation and the Cell Cycle.- Adult Neurogenesis and Central Nervous System Cell Cycle Analysis.- Neurogenesis in Alzheimer’s Disease.-The Biology of Gliomas.- p53 and Multidrug Resistance Transporters in the Central Nervous System.- Signaling Modules in Glial Tumors and Implications for Molecular Therapy.- Detection of Proliferation in Gliomas by Positron Emission Tomography Imaging.- Transformation of Normal Astrocytes Into a Tumor Phenotype.- Mechanisms of Gliomagenesis.- Future Directions.- Cell Cycle of Encapsulated Cells.- Viral Vector Delivery to Dividing Cells.- Electrical Stimulation and Angiogenesis.- Developmental and Potential Therapeutic Aspects of Mammalian Neural Stem Cells.- Mammalian Sir2 Proteins.

Editorial Reviews

Reviewer: Celso Agner, MD, MS, MSc (Michigan Neurology Partners)
Description: Since the discovery of central nervous system stem cells, understanding the cell cycle has become crucial for the development of new therapies for conditions such as degenerative diseases. This book is a compilation of the most recent advances in the field.
Purpose: The purpose is to determine the nature of cellular relationships in the central nervous system. Those objectives are met by the authors, who are leading authorities in the field.
Audience: Neurologists, neuroscientists, and neurosurgeons are the main target audience. This is a compilation from many different laboratories, so there is a wide variety of professionals who are, by and large, leading experts in the field.
Features: There is a good fluidity in the division of chapters, which incorporate mechanisms of cell regeneration, prevention of cell death, and mechanisms of cell proliferation in conditions such as glioma. One of the promising areas that has been nicely covered in this book is the neovascularization following extrinsic production of VEGF. This, by itself, may change what is currently thought about chronic stroke therapy in the next 15 to 20 years.
Assessment: This is a good purchase for neurosurgical, neurological, and neuroscience libraries.

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