Table of Contents
Editorial Board and Reviewers viii
List of Contributors ix
Introduction xv
Section 1 | Cancer Causes, Prevention, and Early Detection 1
1 Descriptive Epidemiology 3Rebecca L. Siegel, Kimberly D. Miller, and Ahmedin Jemal
2 Fundamentals of Cancer Epidemiology 15Susan M. Gapstur and Eric J. Jacobs
3 Socioeconomic Inequalities in Cancer Incidence and Mortality 23Gopal K. Singh and Ahmedin Jemal
4 The Global Burden of Cancer 33Ahmedin Jemal and Lindsey A. Torre
5 Counseling and Testing for Inherited Predisposition to Cancer 45Emily Glogowski, Kasmintan A. Schrader, Kelly L. Stratton, and Kenneth Offit
6 Tobacco 58Thomas J. Glynn, Richard D. Hurt, and J. Lee Westmaas
7 Microbial Carcinogens 72Edgar P. Simard and Ahmedin Jemal
8 Environmental and Occupational Carcinogens 81Elizabeth Ward
9 Nutrition and Physical Activity for Cancer Prevention 92Stacey Fedewa, Rebecca L. Siegel, Colleen Doyle, Marji L. McCullough, and Alpa V. Patel
10 Sun Protection 99Andrew C. Walls and Martin A. Weinstock
11 Screening and Early Detection 110Robert A. Smith, Otis W. Brawley, and Richard C. Wender
Section 2 | Cancer Biology 137
12 The Principles and Drivers of Cancer 139Charles Saxe and William C. Phelps
Section 3 | Diagnosis 153
13 Imaging in Oncology 155Andreas G. Wibmer, Andreas M. Hötker, Maura Miccò, David M. Panicek, and Hedvig Hricak
14 The Pathologic Evaluation of Neoplastic Diseases 164John D. Pfeifer and Mark R. Wick
15 Cancer Staging 184Frederick L. Greene and Lauren A. Kosinski
Section 4 | Treatment Modalities 191
16 Surgical Oncology Overview 193M. Andrew Sicard and Benjamin D. Li
17 Radiotherapy 204Curtiland Deville, Jr., Gaurav Shukla, Ramesh Rengan, and Charles R. Thomas, Jr.
18 Cytotoxic Chemotherapy 220R. Donald Harvey and Fadlo R. Khuri
19 Hormonal Therapy for Cancer 236Amelia B. Zelnak and Bradley C. Carthon
20 Immunotherapy of Cancer 244Diwakar Davar, Ahmad A. Tarhini, and John M. Kirkwood
21 Targeted Therapies 267Elizabeth Kessler, Paul Brittain, S. Lindsey Davis, Stephen Leong, S. Gail Eckhardt, and Christopher H. Lieu
22 Hematopoietic Stem Cell Transplantation for Cancer 284Joshua F. Zeidner, Christopher G. Kanakry, and Leo Luznik
23 Diet, Physical Activity, and Weight Control for Cancer Patients and Survivors 293Wendy Demark-Wahnefried, Laura Q. Rogers, Catherine M. Alfano, Cynthia A. Thomson, Kerry S. Courneya, Jeffrey A. Meyerhardt, Nicole L. Stout, Elizabeth Kvale, Heidi Ganzer, Ted Gansler, and Jennifer A. Ligibel
24 Clinical Trials 306Olwen M. Hahn and Richard L. Schilsky
25 Complementary and Alternative (Integrative) Oncology 315Gabriel Lopez, Richard Lee, M. Kay Garcia, Alejandro Chaoul, and Lorenzo Cohen
Section 5 | Geriatric Oncology 323
26 Geriatric Oncology 325Arvind M. Shinde, Sumanta K. Pal, and Arti Hurria
Section 6 | Symptom Management, Palliative Care, Complications and Toxicities of Treatment, Patient-Reported Outcomes, etc. 333
27 Palliative and Supportive Care 335Rony Dev and Eduardo Bruera
28 Sexuality and Fertility 359Jeanne Carter, Shari B. Goldfarb, Yukio Sonoda, Christian J. Nelson, Maura N. Dickler, and John P. Mulhall
29 Psychiatric Issues in Cancer Patients 379Andrew J. Roth and Adrienne Jaeger
30 Oncologic Emergencies 393Mark A. Lewis, William J. Hogan, and Timothy J. Moynihan
31 Patient-Reported Outcomes in Cancer: Application and Utility in Clinical Practice and Research 409Kevin D. Stein, Tenbroeck Smith, Joseph E. Bauer, Deborah L. Driscoll, and Dexter L. Cooper
32 Survivorship Care 419Emily Tonorezos, Shrujal S. Baxi, Victoria Blinder, Darren R. Feldman, Danielle Novetsky Friedman, Matthew Matasar, Talya Salz, Armin Shahrokni, and Kevin C. Oeffinger
Index 437