Systems Neuroscience

by Albert Cheung-Hoi Yu, Lina Li

Overview

This edition of Advances in Neurobiology brings together experts in the emerging field of Systems Neuroscience to present an overview of this area of research. Topics covered include: how different neural circuits analyze sensory information, form perceptions of the external world, make decisions, and execute movements; how nerve cells behave when connected together to form neural networks; the relationship between molecular and cellular approaches to understanding brain structure and function; the study of high-level mental functions; and studying brain pathologies and diseases with Systems Neuroscience. A hierarchy of biological complexity arises from the genome, transcriptome, proteome, organelles, cells, synapses, circuits, brain regions, the whole brain, and behaviour. The best way to study the brain, the most complex organ in the body composed of 100 billion cells with trillions of interconnections, is with a Systems Biology approach. Systems biology is an inter-disciplinary field that focuses on complex interactions within biological systems to reveal 'emergent properties' - properties of cells and groups of cells functioning as a system whose actual and theoretical description is only possible using Systems Biology techniques.

Product Details

ISBN-13:	9783030068806
Publisher:	Springer International Publishing
Publication date:	01/07/2019
Series:	Advances in Neurobiology , #21
Edition description:	Softcover reprint of the original 1st ed. 2018
Pages:	307
Product dimensions:	6.10(w) x 9.25(h) x (d)

About the Author

Albert Cheung-Hoi YU, PhD, JP,

Dr.Yu received his PhD from the University of Saskatchewan, Canada and spent the subsequent years at various institutions, including UCSF, Stanford, HKUST and the Peking University. Undoubtedly, he possesses a broad cross-cultural experience base and is actively involved in both the academic and the business environment for over 40 years. He is now a world-renowned bio-entrepreneur and a scientist with over 20 years of experience in this field. Moreover, he has published over 170 peer-reviewed scientific papers in reputed international journals, in addition to publishing several commentaries in journals like Science and Nature Biotechnology. Apart from his aforementioned designations, Prof. Yu is also the founder and the president of Guangdong-Hong Kong-Macau Greater Bay Area Biotechnology Alliance, on the board of trustees of the Gordan Research Conference, Justice of the Peace and a former member of the board of directors of the Hong Kong Science and Technology Park (HKSTP). With a global network and an expanding base of established contacts in China, Prof. Yu has been a significant facilitator of dialogue regarding the development of the biotech sector in Asia.

Kai Gao, PhD,

Dr. Kai Gao is Assistant Professor at Children’s Medical Center, Peking University First Hospital, Beijing, China. He received his PhD from Neuroscience Research Institute, Peking University. He received postdoctoral training at Peking University First Hosptial. He is mainly engaged in the research of pathogenic genes, pathogenesis and intervention strategies of neurodevelopmental disorders in children. He has hosted or is hosting 2 projects of National Natural Science Foundation and 1 project of Beijing Natural Science Foundation. He has published 42 peer-reviewed scientific papers including Brain, Science Bulletin (Beijing), World Journal of Pediatrics, Movement Disorders, Glia, and Epilepsia.

Jiangshan Zhan, PhD,

Dr. Jiangshan Zhan received his B.Sc. in medicine from Peking University, China and Ph.D. in medical research from University of Munich (Ludwig Maximilian University of Munich), Germany with highest degree Summa cum laude. He received postdoctoral training at Neuroscience Research Institute, Peking University, China and Jan and Dan Duncan Neurological Research Institute, Baylor College of Medicine, USA. He is currently review editor and youth editorial member for prestigious journals such as Neural Regeneration Research, Innovation Discovery, Frontiers in Molecular Neuroscience, Neurochemical Research and committee member of the Hong Kong Biotechnology Organization. He has published 3 academic books and 23 journal papers including Cell Genomics, Cell reports, Glia, Neurobiology of Disease, and Immunology.

Table of Contents

Neuronal bases of systemic organization of behavior.- Neural circuits mediating fear learning and extinction.- The hippocampal ensemble code for spatial navigation and episodic memory.- Context-dependent adjustments in executive control of goal-directed behaviour: Contribution of frontal brain areas to conflict-induced behavioural adjustments in primates.- Synaptic excitatory-inhibitory balance underlying efficient neural coding.- Mapping molecular datasets back to the brain regions they are extracted from: Remembering the native countries of hypothalamic expatriates and refugees.- Genome-Scale Brain Metabolic Networks as Scaffolds for the Systems Biology of Neurodegenerative Diseases: Mapping Metabolic Alterations.- Synaptic Plasticity and Synchrony in the Anterior Cingulate Cortex Circuitry: A Neural Network Approach to Causality of Chronic Visceral Pain and Associated Cognitive Deficits.- Large de novo microdeletion in epilepsy with intellectual and developmental disabilities, with a systems biology analysis.- Using Systems Biology and Mathematical Modeling Approaches in the Discovery of Therapeutic Targets for Spinal Muscular Atrophy.- Not Cure but Heal: Music and Medicine.