Table of Contents
Preface xix
Tribute xxi
List of Contributors xxviii
About the Companion Website xxxiii
CHAPTER 1 Systematic Reviews in Health Research: An Introduction 1Matthias Egger, Julian P.T. Higgins, and George Davey Smith
PART I Principles and Procedures 17
CHAPTER 2 Principles of Systematic Reviewing 19Julian P.T. Higgins, George Davey Smith, Douglas G. Altman, and Matthias Egger
CHAPTER 3 Identifying Randomized Controlled Trials 36Julie Glanville and Carol Lefebvre
CHAPTER 4 Assessing the Risk of Bias in Randomized Trials 55Matthew J. Page, Douglas G. Altman, and Matthias Egger
CHAPTER 5 Investigating and Dealing with Publication Bias and Other Reporting Biases 74Matthew J. Page, Jonathan A.C. Sterne, Julian P.T. Higgins, and Matthias Egger
CHAPTER 6 Managing People and Data 91Eliane Rohner, Julia Bohlius, Bruno R. da Costa, and Sven Trelle
CHAPTER 7 Reporting and Appraisal of Systematic Reviews 109Larissa Shamseer, Beverley Shea, Brian Hutton, and David Moher
PART II Meta-Analysis 129
CHAPTER 8 Effect Measures 131Julian P.T. Higgins, Jonathan J. Deeks, and Douglas G. Altman
CHAPTER 9 Combining Results Using Meta-Analysis 159Jonathan J. Deeks, Richard D. Riley, and Julian P.T. Higgins
CHAPTER 10 Exploring Heterogeneity 185Julian P.T. Higgins and Tianjing Li
CHAPTER 11 Dealing with Missing Outcome Data in Meta-Analysis 204Ian R. White and Dimitris Mavridis
CHAPTER 12 Individual Participant Data Meta-Analysis 220Mark C. Simmonds and Lesley A. Stewart
CHAPTER 13 Network Meta-Analysis 238Georgia Salanti and Julian P.T. Higgins
CHAPTER 14 Dose-Response Meta-Analysis 258Nicola Orsini, Susanna C. Larsson, and Georgia Salanti
PART III Specific Study Designs 271
CHAPTER 15 Systematic Reviews of Nonrandomized Studies of Interventions 273Jelena Savovic, Penny F. Whiting, and Olaf M. Dekkers
CHAPTER 16 Systematic Reviews of Diagnostic Accuracy 296Yemisi Takwoingi and Jonathan J. Deeks
CHAPTER 17 Systematic Reviews of Prognostic Factor Studies 324Richard D. Riley, Karel G.M. Moons, Douglas G. Altman, Gary S. Collins, and Thomas P.A. Debray
CHAPTER 18 Systematic Reviews of Prediction Models 347Gary S. Collins, Karel G.M. Moons, Thomas P.A. Debray, Douglas G. Altman, and Richard D. Riley
CHAPTER 19 Systematic Reviews of Epidemiological Studies of Etiology and Prevalence 377Matthias Egger, Diana Buitrago-Garcia, and George Davey Smith
CHAPTER 20 Meta-Analysis in Genetic Association Studies 396Gibran Hemani
PART IV Cochrane and Guideline Development 413
CHAPTER 21 Cochrane: Trusted Evidence. Informed Decisions. Better Health 415Gerd Antes, David Tovey, and Nancy Owens
CHAPTER 22 Using Systematic Reviews in Guideline Development: The GRADE Approach 424Holger J. Schünemann
PART V Outlook 449
CHAPTER 23 Innovations in Systematic Review Production 451Julian Elliott and Tari Turner
CHAPTER 24 Future for Systematic Reviews and Meta-Analysis 463Shah Ebrahim and Mark D. Huffman
PART VI Software 481
CHAPTER 25 Meta-Analysis in Stata 483David J. Fisher, Marcel Zwahlen, Matthias Egger, and Julian P.T. Higgins
CHAPTER 26 Meta-Analysis in R 510Guido Schwarzer
CHAPTER 27 Comprehensive Meta-Analysis Software 535Michael Borenstein
Index 549