Synaptic Stress and Pathogenesis of Neuropsychiatric Disorders

by Maurizio Popoli, David Diamond, Gerard Sanacora

Overview

Recent studies show that changes in Glutamate/GABA synapses and related pathways may determine whether the synaptic plasticity that occurs as a response to stress is adaptive or maladaptive. Findings have shed new light on the mechanisms that determine the effects of stress on cognitive and affective function. Researchers have brought a wide range of techniques to bear on the study of this problem, including cutting-edge live imaging techniques, electrophysiology, glutamate release from isolated live synaptic terminals, development of transgenic and animal models and new behavioral methods. This book provides an overview of these recent findings and of the techniques used as well as a discussion of how the molecular, cellular, and functional effects of stress may trigger or precipitate neuropsychiatric disorders such as depression, schizophrenia, anxiety and PTSD.

Product Details

ISBN-13:	9781493946327
Publisher:	Springer New York
Publication date:	09/03/2016
Edition description:	Softcover reprint of the original 1st ed. 2014
Pages:	355
Product dimensions:	6.10(w) x 9.25(h) x 0.03(d)

Table of Contents

1. The Brain on Stress: The Good and the Bad
Bruce S. McEwen

2. Regulation of Excitatory Synapses by Stress Hormones
Marian Joëls, Harm Krugers, Henk Karst

3. Synaptic Stress, Changes in Glutamate Transmission and Circuitry, and Psychopatology
Laura Musazzi, Giulia Treccani, Carla Perego, Nicoletta Nava, Jens R Nyengaard, Maurizio Popoli

4. Dual Regulation of Glutamatergic Transmission and Cognition by Stress in Prefrontal Cortex Zhen Yan

5. Role of Endocannabinoids in Regulating Glucocorticoid Effects on Memory for Emotionally Arousing Experiences
Piray Atsak, Benno Roozendaal, Patrizia Campolongo

6. Endocannabinoid Signaling & Synaptic Plasticity During Stress
J. Megan Gray, Haley A. Vecchiarelli, Matthew N. Hill

7. Stress Induced Metaplasticity at GABA Synapses
Jaideep S. Bains

8. Stress Modulation of Synaptic Plasticity in the Hippocampus
Menahem Segal, Nicola Maggio

9. Neural-Cognitive Effects of Stress in the Hippocampus
Jeansok J. Kim, Blake A. Pellman, Eun Joo Kim

10. Evolutionary, Historical and Mechanistic Perspectives on How Stress Affects Memory and Hippocampal Synaptic Plasticity
George E. Farmer, Collin R. Park, Laura A. Bullard, David M. Diamond

11. Acute Stress Disrupts Short- and Long-term Patterns of Synaptic Plasticity in Dorsal Hippocampus and Subiculum: Implications for Hippocampal Output and Behaviour
John G. Howland, Don A. Davies

12. Synaptic Mechanisms and Cognitive Computations Underlying Stress Effects on Cognitive Function
Gediminas Luksys, Carmen Sandi

13. Altered GABA Function in Major Depression
Beverly French, Marianne L. Seney, Etienne Sibille

14. Pathology in Astroglia, Glutamate and GABA in Major Depressive Disorder: Evidence from Studies of Human Postmortem Tissue
Grazyna Rajkowska

15. Evidence of Glutamatergic Dysfunction in the Pathophysiology of SchizophreniaJ.C. Hammond, D. Shan, J.H. Meador-Woodruff, R.E. McCullumsmith

16. Metabolic Stress and Neuropsychiatric Disorders
Claudia A. Grillo, Lawrence P. Reagan

17. Using our Understanding of Stress Related Effects on Glutamate Neurotransmission to Guide the Development of Novel Treatment Strategies
Carly Kiselycznyk, Gerard Sanacora

Editorial Reviews

From the book reviews:

“This informative book, written and edited by an international array of well-known stress researchers, provides the latest information on the molecular mechanisms mediating stress in the pathogenesis of neuropsychiatric illnesses. … The target audience includes bench neuroscientists and clinicians who want to learn about the latest research on fundamental neuroendocrine stress mechanisms and stress-related diseases. … Each chapter ends with relevant and timely citations of the scientific literature.” (Michael Joel Schrift, Doody’s Book Reviews, January, 2015)

From the Publisher

Reviewer: Michael Schrift, DO (University of Washington School of Medicine)
Description: Stress, as we all know, is ubiquitous and has certainly been linked as a cause or risk factor for hundreds of years to a multitude of medical and neuropsychiatric illness. The molecular and genetic mechanisms involved in the mediation of how stress can lead to illness have only recently been revealed. This informative book, written and edited by an international array of well-known stress researchers, provides the latest information on the molecular mechanisms mediating stress in the pathogenesis of neuropsychiatric illnesses.
Purpose: The purpose, according to the editor, is to provide "an overview of the ways in which stress affects brain function or synaptic plasticity and can precipitate the onset of neuropsychiatric disorders."
Audience: The target audience includes bench neuroscientists and clinicians who want to learn about the latest research on fundamental neuroendocrine stress mechanisms and stress-related diseases.
Features: The book opens with an outstanding overview by Bruce McEwen of the effects of stress on the brain. Subsequent topics include regulation of excitatory synapses, changes in glutaminergic transmission and circuitry, the role of glutamate in the regulation of cognition and the prefrontal cortex in stress, the role of endocannabinoid effects on memory with emotionally arousing stimuli, endocannabinoid signally and synaptic plasticity in stress, stress effects on GABA synapses, stress and the hippocampus and the cognitive consequences, an evolutionary perspective of how stress affects memory and hippocampal function, altered GABA in major depression, glutaminergic dysfunction in schizophrenia, metabolic stress in neuropsychiatric disorders, and the development of novel treatment strategies with the knowledge of how stress affects glutaminergic neurotransmission. Each chapter ends with relevant and timely citations of the scientific literature.
Assessment: This is an illuminating book on the mechanisms of how stress is involved in the pathophysiology of neuropsychiatric disorders. More useful for researchers than clinicians, the book is a great update on this important topic and is a welcome addition to the field. However, the $200+ price might cause you some stress!

Doody's Review Service