Protease Inhibitors as Cancer Chemopreventive Agents / Edition 1

by W. Troll, A. R. Kennedy

Overview

This is the only work to comprehensively review the use of proteases as inhibitors in carcinogenesis. Their mechanisms of inhibition, potential adverse side effects, and distribution in plants and animals are all discussed in detail to provide researchers and clinicians with a thorough understanding of this increasingly important field.

Product Details

ISBN-13:	9780306443909
Publisher:	Springer-Verlag New York, LLC
Publication date:	01/28/1993
Edition description:	New Edition
Pages:	334
Product dimensions:	6.69(w) x 9.45(h) x (d)

Table of Contents

The Epidemiological Approach to the Study of Protease Inhibitors (Fontham, Correa). In vitro Studies of Anticarcinogenic Protease Inhibitors (Kennedy). Discovery and Background of the BowmanBirk Protease Inhibitors (Bowman). Antigenicity of Soybean Protease Inhibitors (Bandon et al.). Low Molecular Weight Protease Inhibitors of Microbial Origin (Umezawa et al.). Protease Inhibitor Synthesis by MCF7 Breast Cancer Cells (Finlay et al.). Analysis of StructurActivity Relationships of the BowmanBirk Inhibitor of Serine Proteases (Flecker). Prevention of Cancer by Vitamin B3 (Troll). Approaches to Studying the Target Enzymes of Anticarcinogenic Protease Inhibitors (Billings). Anticarcinogenic Activities of Naturally Occuring Cysteine Protease Inhibitors (Colella et al.). Cell Membrane Enzymes Containing ChymotrypsinLike Activity (Yavelow et al.). The Role of Active Oxygen Species in Biological Damage and the Effect of Some Chemopreventative Agents (Frenkel). 6 additional articles. Index.

Editorial Reviews

Protease inhibitors (PIs), which are widely distributed in plants and animals and have a variety of functions, interfere with cancer development in a number of ways, including suppression of oxygen radicals, oncogenes, and metastases. Epidemiologic evidence supports their prevention of major human cancers in populations that consume foods containing them. Their supervised use in humans is on the threshold of development. This volume contains 18 contributed chapters on aspects of both natural and synthetic PIs as chemopreventive agents. Annotation c. Book News, Inc., Portland, OR (booknews.com)

Booknews