Table of Contents
List of contributors vii
Introduction xi
Section I: Preclinical sciences of stress
1 Posttraumatic stress disorder: from neurobiology to clinical presentation 3Arieh Y. Shalev & J. Douglas Bremner
2 The epidemiology of posttraumatic stress disorder in children and adolescents: a critical review 27Leah A. McGuire
3 Early life stress and development: preclinical science 61Dora B. Guzman, Brittany Howell & Mar Sanchez
4 Amygdala contributions to fear and safety conditioning: insights into PTSD from an animal model across development 81Christopher Cain & Regina Sullivan
5 Preclinical evidence for benzodiazepine receptor involvement in the pathophysiology of PTSD comorbid substance abuse and alcoholism 105Robert Drugan, Nathaniel P. Stafford & Timothy A. Warner
6 Psychosocial predator stress model of PTSD based on clinically relevant risk factors for trauma-induced psychopathology 125Phillip R. Zoladz & David Diamond
7 Coping with stress in wild birds – the evolutionary foundations of stress responses 145Molly J. Dickens & Michael Romero
8 Stress fear and memory in healthy individuals 159Christian J. Merz, Bernet M. Elzinga & Lars Schwabe
Section II: Neurobiology of PTSD
9 Neurotransmitter neurohormonal and neuropeptidal function in stress and PTSD 181J. Douglas Bremner & Brad Pearce
10 Genomics of PTSD 233Anthony S. Zannas, Elisabeth Binder & Divya Mehta
11 Cortisol and the Hypothalamic–Pituitary–Adrenal Axis in PTSD 265Amy Lehrner, Nicolaos Daskalakis & Rachel Yehuda
12 Neuroimaging of PTSD 291Carolina Campanella & J. Douglas Bremner
Section III: PTSD and co-occuring conditions
13 PTSD and mild traumatic brain injury 321J. Douglas Bremner
14 Stress-related psychopathology and pain 345Sarah C. Reitz, Karl-Juergen Bär & Christian Schmahl
15 Stress and health 361Viola Vaccarino, Emeran Mayer & J. Douglas Bremner
Section IV: PTSD: From neurobiology to treatment
16 Pharmacotherapy for PTSD: effects on PTSD symptoms and the brain 389Lori Davis, Mark Hamner & J. Douglas Bremner
17 Effects of psychotherapy for psychological trauma on PTSD symptoms and the brain 413J. Douglas Bremner & Carolina Campanella
Index 421