Pathophysiology and Pharmacology of Erythropoietin / Edition 1

by Horst Pagel, Christoph Weiss, Wolfgang Jelkmann

Overview

The book contains a series of about 40 articles reflecting the state-of-the-art of the topic "Pathophysiology and
Pharmacology of Erythropoietin". Results from both basic research and clinical studies are described in detail. The papers show that the possible therapeutic spectrum of erythropoietin could be expanded considerably when compared with the present situation.

Product Details

ISBN-13:	9783642770760
Publisher:	Springer Berlin Heidelberg
Publication date:	11/24/2011
Edition description:	Softcover reprint of the original 1st ed. 1992
Pages:	328
Product dimensions:	6.10(w) x 9.25(h) x 0.03(d)

Table of Contents

List of Contents.- I. Structure and Action.- Structure-Function Relationships of Erythropoietin.- Isoforms of Recombinant Human Erythropoietin.- Activation of the Erythropoietin Receptor in the T3C12 Friend Erythroleukemia Cell Line.- II. Sites and Control of Production.- The Role of Adenosine in Hypoxic Regulation of Kidney Production of Erythropoietin.- Oxygen Shunt Diffusion in Renal Cortex and Its Physiological Link to Erythropoietin Production.- Oxygen Sensing and Erythropoietin mRNA Production in Isolated Perfused Rat Kidneys.- Analysis of Erythropoietin Gene Expression by Means of Competitive Polymerase Chain Reaction.- The Developmental Biology of Erythropoiesis and Erythropoietin: Is Erythropoietin a True Hormone or a Paracrine Factor.- Insulin-like Growth Factor 1 and Erythropoiesis During Growth.- III. Blood Levels in Health and Disease.- Clinical Applicability of the Determination of Erythropoietin.- A Sensitive ELISA for Erythropoietin and Its Application in Various Diseases.- Use of Erythropoietin Radioimmunoassay in Polycythemias.- Effects of Exercise on Plasma Erythropoietin in Natives Living Permanently at High Altitude.- Erythropoietin Concentration in Renal Venous Blood in Patient with Renovascular Hypertension: Is It a Marker of Renal Ischemia.- Serum Erythropoietin Levels in Von Hippel-Lindau Syndrome.- IV. Erythropoietin Replacement in Renal Failure.- Iron Metabolism Under Treatment of Renal Anemia with Recombinant Human Erythropoietin.- Erythropoietin Treatment in Children with Renal Anemia.- Bone Marrow Erythroid Precursor Cytoplasmic Ca2+ and 1, 25-Dihydroxyvitamin D3 Regulate the Response to Human Recombinant Erythropoietin in Uremia: In Vitro and In Vivo Studies.- Dyserythropoietic Abnormalities in Hemodialysis Patients on Long-Term Therapy with Human Recombinant Erythropoietin.- Cardiological Findings in Patients with End-Stage Renal Failure Under Treatment with Erythropoietin.- Long-Term Treatment with Recombinant Human Erythropoietin in Haemodialysis Patients: Effects on Left Ventricular Performance.- Retinal Hypoxia and Anemia in Chronic Renal Failure: Effect of Erythropoietin.- Experience with Subcutaneous Versus Intravenous Administration of Erythropoietin in Haemodialysis Patients.- Pharmacodynamic Aspects of Recombinant Human Erythropoietin - Long-Term Results in Patients with Hemodialysis Treatment.- Comparison of Three Routes of Administration of Recombinant Human Erythropoietin Expressed in C-127 Mouse Cells.- Peritoneal Permeability in Continuous Ambulatory Peritoneal Dialysis After the Correction of Anemia by Erythropoietin.- V. Primary Hemopoietic Disorders and Chemotherapy.- Serum Erythropoietin Levels in Aplastic Anemia Determined by ELISA.- Serum Erythropoietin in Myelodysplasia Syndromes.- Antigenic Characteristics of Erythropoietin-Dependent and -Independent Erythroid Progenitors in Chronic Myeloproliferative Disorders Defined by Monoclonal Antibodies.- Chemotherapy and Erythropoietin Production.- Production of Erythropoietin During and After Thiamphenicol Treatment Occurs Independently of Peripheral Blood Cell Numbers.- VI. Application of Recombinant Erythropoietin in Non-Renal Anemia.- Effects of Inflammatory Cytokines on the Production of Erythropoietin.- The Use of Recombinant Human Erythropoietin in the Treatment of the Anemia of Chronic Disorders.- Recombinant Human Erythropoietin in the Treatment of Anaemia in Rheumatoid Arthritis.- Erythropoietin in Neoplastic Diseases: Preliminary Results.- Erythropoietin Effects on Acute Anemia Induced by Antineoplastic Therapy in the Case of a Uremic Patient with Lymphoma.- The Therapeutic Effect of Recombinant Human Cytokines (GM-CSF, Interleukin-3, Erythropoietin) in Patients with Myelodysplasia Syndromes.- The Effect of Erythropoietin in Chemotherapy-Induced Anaemia in Patients with Osteosarcoma and Ewing’s Sarcoma.- Erythropoietin in Bone Marrow Transplantation: Pathophysiology and Clinical Use.- Experimental and Clinical Results of Perioperative Treatment with Recombinant Human Erythropoietin.