New Concepts of a Blood-Brain Barrier / Edition 1

by D.J. Begley, J. Greenwood, M. Segal

Overview

The scientific contribution of Mike Bradbury to the study of the blood-brain barrier is considerable and wide-ranging, starting with his M.D. thesis in 1962 and still continuing today. The varied spectrum of topics relating to the blood-brain barrier presented in this volume and the many geographical locations from which both speakers and participants gathered to attend the symposium are a fitting testament both to Mike's wide-spread influence in the field and to the esteem in which he is held. When we first had the idea of afestschrift to mark Mike's retirement as Professor of Physiology at King's College London and the beginning of a new vie libre as scientist and yachtsman the plan was initially for a gathering of all of the many colleagues, collaborators and students who had worked with him over the years. However what we had not taken into account was the closeness of the international community of workers in the field, the widespread influence that Mike had wielded and the speed with which word would spread. We should have anticipated all three. The final outcome was an excellent symposium with the majority of the world's key workers either contributing or attending. We hope that this volume presents an adequate record of the meeting.

Product Details

ISBN-13:	9780306452048
Publisher:	Springer US
Publication date:	01/31/1996
Edition description:	1995
Pages:	332
Product dimensions:	7.01(w) x 10.00(h) x 0.03(d)

Table of Contents

Developing Views of the Blood-Brain Barrier; M.W.B. Bradbury. Development of the Blood-Brain Barrier; B. Engelhart, W. Risau. Electrical Resistance Measurements of Blood-Brain Barrier Permeability; A.M. Butt. The Application of Quantitative Immunocyhemistry for the Evaluation of Blood-Brain Barrier to Exogenous Albumin; A.W. Vorbrodt. Endothelin as a Mediator of Blood-Brain Barrier Function; M. Spatz, et al. The Role of the Endothelial Cell Surface Charge for Blood-Brain Barrier Function; B.B. Johanssen. Capillary Permeability in Central and Peripheral Nerve Tissue in Streptozoin Diabetes in the Anaethetised Rat; G.G. Pinter, M.W.B. Bradbury. Serotonin as a Mediator of Increased Microvascular Permeability of the Brain and Spinal Cord: Experimental Observations in Anaesthetised Rats and Mice; H.S. Sharma, et al. Molecular Regulation of Blood-Brain Barrier Glut1 Glucose Transporter; W.M. Pardridge. The Dependency of Influx across the Blood-Brain Barrier on Blood Flow and the Apparent Flowindependence of Glucose Influx during Stress; J.D. Fenstermacher, et al. Brain-Blood Barrier Removal of DOPA: Role in Regulation of Dopamine Synthesis and Treatment of Parkinson's Disease; A. Gjedde, et al. 20 additional articles. Index.

Editorial Reviews

Among the 31 topics are evolving views of the blood-brain barrier, endothelin as a mediator of blood-brain function, the molecular regulation of GLUT1 glucose transporter, nasal cerebrospinal fluid drainage in humans, isolated brain microvessels and cultured cerebral endothelial cells, carrier- mediated drug transport at the blood-brain barrier and its impact on the potential for targeting drugs to the brain, and how a determined lymphocyte can always get around the barrier. Annotation c. Book News, Inc., Portland, OR (booknews.com)

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