New Advances in Histamine Research

by Kenji Tasaka

Overview

Recent research has given great insight into the physiological and pharmaceutical effects of histamine on the central nervous system and especially on the brain. This volume focuses on these many new findings, including the role of brain histamine in the arousal system, learning, and memory. Also featured are the mechanisms of histamine release in bone marrow and mast cells and the role of histamine in neutrophil differentiation. These are analyzed using the most up-to-date techniques of molecular pharmacology and refined immunoelectroscopy. In addition, the pharmacological profiles of newly developed H1 antagonists are described, making this book invaluable to those who want to understand the very latest advances in histamine research.

Product Details

ISBN-13:	9784431682653
Publisher:	Springer Japan
Publication date:	12/08/2011
Edition description:	Softcover reprint of the original 1st ed. 1994
Pages:	330
Product dimensions:	6.69(w) x 9.61(h) x 0.03(d)

Table of Contents

1 Excitatory effect of histamine on the arousal system.- 1. Introduction.- 2. EEG power spectral analysis.- 3. Changes in EEG patterns and EEG spectral powers recorder at the frontal cortex (FCOR) and the nucleus ventralis thalami (VE) after electrical stimulation to the RF.- 4. Influence of the stimulation frequency and voltage.- 5. Changes in EEG spectral powers after stimulation to the certain areas of the RF.- 6. Effects of histamine and its related compounds on EEG spectral powers.- 7. Effects of Hi And H2 antagonists on histamine-induced decrease in EEG spectral powers.- 8. Effects of H3 agonists and antagonist on EEG spectral powers.- 9. The pathway responsible for EEG synchronization and effect of histamine on this system.- 10. Conclusion.- References.- 2 The role of histamine on learning and memory.- 1. Introduction.- 2. One-way active avoidance and passive avoidance.- 3. Age-related changes in acquisition and retention.- 4. Recovery of memory deficit in relation with a long interruption of training in old rats.- 5. Role of endogenous histamine in learning and memory.- 6. Learning and memory deficits induced by hippocampal lesions.- 7. Effects of certain Hi antagonists on active avoidance response.- 8. Conclusion.- References.- 3 Role of brain histamine on corticosteroid release.- 1. Introduction.- 2. Effect of parenteral administration of histamine on plasma ACTH and corticosteroid concentrations.- 3. Effect of intracerebroventricular injection of histamine on plasma ACTH and corticosteroid concentrations.- 4. Effects of H1 and H2 agonists on plasma ACTH and corticosteroid concentrations.- 5. Effects of H1 and H2 antagonists on the elevation of plasma ACTH and corticosteroid concentrations induced by histamine or 4-methylhista-mine.- 6. Effects of H3 agonist and antagonist on plasma ACTH and corticosterone concentrations in rats.- 7. Effect of CRF on plasma ACTH and corticosteroid concentrations.- 8. Effect of histamine on plsama ACTH and corticosteroid concentrations in hypophysectomized animals.- 9. Histamine depletion in rat brain and its influence on corticosterone release.- 10. Influence of lesions or stimulation to the posterior hypothalamus.- 11. Interaction between the posterior hypothalamus and the adrenal gland.- 12. Effects of some neurotransmitters on steroidogenesis in dog adrenocortical cells.- 13. Conclusion.- References.- 4 Role of Ca2+ and cAMP in histamine release from mast cells.- 1. Intracellular Ca2+ release induced by histamine releasers and its inhibition by some antiallergic drugs.- 2. Inhibition of intracellular Ca mobilization, Ca uptake and histamine release induced by some antiallergic drugs.- 3. Sequential analysis of histamine release and intracellular Ca2+ release from murine mast cells.- 4. Ca uptake and Ca releasing properties of the endoplasmic reticulum in rat peritoneal mast cells.- 5. Role of endoplasmic reticulum, an intracellular Ca2+ store, in histamine release from mast cell.- 6. Histamine release from—-escin-permeabilized rat peritoneal mast cells and its inhibition by intracellular Ca2+ blockers, calmodulin inhibitors and cAMP.- 7. Role of ATP and activation of protein kinase C in Ca2+-dependent histamine release from permeabilized rat mast cells.- 8. Ca2+-induced translocation of protein kinase C during Ca2+-dependent histamine release from—-escin-permeabilized mast cells.- 9. Phosphorylation of smg p21B in rat peritoneal mast cells in association with histamine release inhibition by dibutyryl-cAMP.- References.- 5 Role of cytoskeleton in the histamine release from mast cells.- 1. Role of microfilaments in the exocytosis of rat peritoneal mast cells.- 2. Microfilament-associated degranulation.- 3. Role of microtubules on Ca2+ release from the endoplasmic reticulum and associated histamine release from rat peritoneal mast cells.- 4. Identification of vimentin in rat peritoneal mast cells and its phosphorylation in association with histamine release.- References.- 6 Histamine release induced by basic peptides and proteins.- 1. Substance P-induced histamine release from rat peritoneal mast cells and its inhibition by antiallergic agents and calmodulin inhibitors.- 2. Histamine release induced by histone and related morphological changes in mast cells.- 3. Guinea pig eosinophil major basic protein as a potent histamine releaser.- References.- 7 Inhibitory effect of interleukin-2 on the histamine release from rat peritoneal mast cells in association with the production of lipocortin-I.- 1. Introduction.- 2. Inhibitory effects of interleukin-2 on histamine release from rat peritoneal mast cells induced by compound 48/80 and concanavalin A.- 3. Effect of IL-2 on 45Ca uptake and IP3 production in rat peritoneal mast cells.- 4. Effect of IL-2 on cAMP-protein kinase A system in rat mast cells.- 5. [3H] -Leucine uptake into rat mast cells elicited by IL-2.- 6. Determination of the protein synthesis elicited by IL-2.- 7. Western blotting analysis of lipocortin-I induced by IL-2.- 8. Participation of tyrosine kinase in histamine release inhibition due to IL-2.- 9. Discussion.- References.- 8 Histamine-induced leukocytosis.- 1. Introduction.- 2. Histamine-induced leukocytosis in experimental animals.- 3. Effect on neutrophil precursors.- 4. Histamine and cell proliferation.- 5. Histamine-induced differentiation of HL-60 cells: Analysis of the mechanism of action of histamine.- 6. Effect of histamine on IL-1 production in bone marrow stromal cells.- 7. Histamine-induced extemalization of G-CSF receptor.- References.- 9 Pharmacology of newly developed H1 antagonists: antiallergic profile of H1 antagonists.- 1. Introduction.- 2. Determination of Hi antagonistic activity (isolated guinea pig ileum).- 3. Effect on histamine release and SRS-A release.- 4. Effect on 45Ca uptake and intracellular Ca mobilization.- 5. The role of cyclic nucleotide for inhibition of histamine release.- 6. Effect on bronchoconstriction in guinea pigs.- 7. Effect on cutaneous reaction in rats.- 8. Effect on experimental allergic rhinitis.- 9. Effect on experimental allergic conjunctivitis.- 10. Effect on LTs- or PAF-induced contractions of isolated guinea pig trachea.- 11. Effect on rabbit platelet aggregation induced by PAF.- 12. Effect on the central nervous system.- 13. conclusion.- References.