Neurotransmitter Receptors in Actions of Antipsychotic Medications / Edition 1

by Philip Seeman, Michael S. Lidow, Mannfred A. Hollinger, Ronald E. See, Ashiwel S. Undie

Overview

Years of extensive investigation into neurophysiology, neurochemistry, and behavioral pharmacology have produced an understanding of antipsychotic medication action that is much more refined than the original dopamine hypothesis. New perspectives offer an array of novel drugs - drugs that pose a lower risk of developing tardive dyskinesia, have fewer extrapyramidal side effects, are less sedating, and attempt to address the negative symptoms of schizophrenia. Neurotransmitter Receptors in Actions of Antipsychotic Medications presents a glimpse into the development of these breakthroughs and the field's current status in one definitive volume.

The exhaustive chapters cover the basic knowledge of schizophrenic syndromes and provide a general description of available antipsychotic drugs. Leading specialists recount the investigation into a variety of receptors in drug action and present unique topics like endogenous receptor occupation by antipsychotic drugs and regulation of brain receptors. The book also includes a survey of the future perspectives in drug design.

Each year, pharmaceutical companies invest billions of dollars in developing hundreds of medications to treat psychiatric disorders. Neurotransmitter Receptors in Actions of Antipsychotic Medications helps you study and appreciate the dynamics of these medications. You will understand the effects on receptors; predict the action, adverse side effects, and drug-drug interactions; and improve the modern antipsychotic medications that already enable people coping with schizophrenia to work, have meaningful social relationships, and live more productive lives.

Product Details

ISBN-13:	9780849307447
Publisher:	Taylor & Francis
Publication date:	06/22/2000
Series:	Handbooks in Pharmacology and Toxicology
Pages:	272
Product dimensions:	7.00(w) x 10.00(h) x (d)

Table of Contents

Schizophrenic Syndromes. General Overview of Antipsychotic Medications. Effects of Antipsychotic Drugs on Dopamine Release and Metabolism in the Central Nervous System. Antipsychotic Drugs, Dopamine D2, and Schizophrenia. D1 Dopamine Receptors, Schizophrenia, and Antipsychotic Medications. Serotonin Receptors as Targets of Antipsychotic Medications. Role of Adrenergic Receptors in Effects of Antipsychotic Medications on Prefrontal Cortical Function. Glutamate Receptors in Schizophrenia and Antipsychotic Drugs. Antipsychotic Effects of Sigma Drugs. GABA-ergic Drugs in Schizophrenia. Receptor Occupancy by Antipsychotics - Concepts and Findings. Regulation of Neurotransmitter Receptors by Antipsychotic Medications. Modulation of Cellular Signaling Pathways by Antipsychotic Medications. The Role of Neurotransmitter Receptors in the Adverse Effects of Antipsychotic Drugs. Future Perspectives of Antipsychotic Drug Development.

Editorial Reviews

Reviewer: William Miles, MD (Rush University Medical Center)
Description: This small but very thorough textbook is a review of the current understanding of psychosis and antipsychotic medications. The editor and contributors discuss the various schizophrenic syndromes and review neurophysiology, neurochemistry, and neuroreceptors, and how these disciplines apply to the current understanding of antipsychotic medications.
Purpose: The purpose is to present a thorough review of neurotransmitter receptors, and how antipsychotic drugs target these receptors, resulting in various therapeutic effects.
Audience: The book is targeted more for neuroscience researchers than for clinicians or medical students. However, practicing psychiatrists and psychiatric residents will find the book useful.
Features: The book is composed of numerous chapters, each written by authorities is their respective fields. They begin with a review of schizophrenia, and a general description of the various antipsychotic drugs available. The middle part of the book is a description of the role of various neuroreceptors on the action of antipsychotic drugs. Next, such topics as receptor occupation and modulation by antipsychotic drugs are reviewed. The editor concludes with a discussion of possible future antipsychotic drug design. The few illustrations mostly show chemical structures, and such things as pharmacokinetic data are presented in various tables and graphs.
Assessment: This is an excellent contribution to the fields of psychiatry and neuroscience. A review of a rather complicated subject is presented in a well-organized and thorough manner. The book is not an "easy read," but it is not meant to be. Rather, it is a highly detailed review of antipsychotic drugs and neuroreceptors. There are many reviews of psychopharmacology, but this is one of the most specialized and exhaustive I have read. Any clinician or researcher interested in antipsychotic medications would find it a useful addition to their library.

Doody's Review Service

"This small but very thorough textbook…an excellent contribution to the fields of psychiatry and neuroscience…a rather complicated subject is presented in a well-organized and thorough manner…a highly detailed review of antipsychotic drugs and neuroreceptors. There are many reviews of psychopharmacology, but this is one of the most specialized and exhaustive I have read. Any clinician or researcher interested in antipsychotic medications would find it a useful addition to their library."
-William Miles, M.D., Rush-Presbyterian-St. Luke's Medical Center

From the Publisher

4 Stars! from Doody

This small but very thorough textbook is a review of the current understanding of psychosis and antipsychotic medications. The editor and contributors discuss the various schizophrenic syndromes and review neurophysiology, neurochemistry, and neuroreceptors, and how these disciplines apply to the current understanding of antipsychotic medications. The purpose is to present a thorough review of neurotransmitter receptors, and how antipsychotic drugs target these receptors, resulting in various therapeutic effects. The book is targeted more for neuroscience researchers than for clinicians or medical students. However, practicing psychiatrists and psychiatric residents will find the book useful. The book is composed of numerous chapters, each written by authorities is their respective fields. They begin with a review of schizophrenia, and a general description of the various antipsychotic drugs available. The middle part of the book is a description of the role of various neuroreceptors on the action of antipsychotic drugs. Next, such topics as receptor occupation and modulation by antipsychotic drugs are reviewed. The editor concludes with a discussion of possible future antipsychotic drug design. The few illustrations mostly show chemical structures, and such things as pharmacokinetic data are presented in various tables and graphs. This is an excellent contribution to the fields of psychiatry and neuroscience. A review of a rather complicated subject is presented in a well-organized and thorough manner. The book is not an ""easy read,"" but it is not meant to be. Rather, it is a highly detailed review of antipsychotic drugs and neuroreceptors. There are many reviews ofpsychopharmacology, but this is one of the most specialized and exhaustive I have read. Any clinician or researcher interested in antipsychotic medications would find it a useful addition to their library.

William Miles

Featuring the work of 21 psychiatrists, neurobiologists, and pharmacologists from around the world, this volume presents a theoretical basis for recent breakthroughs and an examination of the field's current status. Introductory chapters cover the basic knowledge of schizophrenic syndromes and provide a general description of available antipsychotic drugs. They are followed by exhaustive accounts of the investigations into the roles of various neurotransmitter receptors in actions of antipsychotic drugs. Information is provided concerning the drugs' mechanism of action, the extent of their side-effects, and their drug-drug interactions. The book also discusses perspectives in future antipsychotic drug design. Annotation c. Book News, Inc., Portland, OR (booknews.com)

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