Nano-biomedical Engineering 2009 - Proceedings Of The Tohoku University Global Centre Of Excellence Programme

by Takami Yamaguchi

Overview

This proceedings volume details both current and future research and development initiatives in nano-biomedical engineering, arguably the most important technology of the world in the 21st century. It deals with the following four groups of nano-biomedical engineering: nano-biomechanics, nano-bioimaging, nano-biodevices, and nano-biointervention.Consisting of a compilation of studies conducted by group members of the Tohoku University Global Center of Excellence Program, with specially coordinated funding from the Japanese Government, the papers emphasize the integration of research and education collaboration between engineering and medicine, and showcase Japan's top-level research in the field of nano-biomedical engineering.

Product Details

ISBN-13:	9781848163522
Publisher:	Imperial College Press
Publication date:	02/26/2009
Pages:	484
Product dimensions:	6.20(w) x 9.10(h) x 1.00(d)

Table of Contents

Foreword v

Section 1 Nano-Biomechanics 1

Measurement Integrated Simulation to Provide Accurate Information of Blood Flows Toshiyuki Hayase Kenichi Funamoto 3

Microelastic Mapping by AFM of Endothelial Cells Exposed to Shear Stress Masaaki Sato Kenichi Suzuki Yosuke Ueki Toshiro Ohashi 17

Inner Ear Biomechanics Hiroshi Wada Michio Murakoshi Koji Iida Shun Kumano Kenji Ishihara 29

Computational Biomechanics for Investigating Cardiovascular Diseases Takami Yamaguchi Hitoshi Kondo Yuji Shimogonya Yohsuke Imai Noriaki Matsuki Takuji Ishikawa 41

Change in Mechanical Properties and Activities of Matrix Metalloproteinases in Rat Aortas Stimulated with Cytokines Wenjing Huang Naoya Sakamoto Toshiro Ohashi Masaaki Sato 51

Formulation of Linearized Error Dynamics Equations of Measurement-Integrated Simulation Kentaro Imagawa Toshiyuki Hayase 57

Evaluation of the Mechanical Properties of Blood Vessel Biomodeling with Poly (Vinyl Alcohol) Hydrogel Hiroyuki Kosukegawa Keisuke Mamada Kanju Kuroki Lei Liu Kosuke Inoue Toshiyuki Hayase Makoto Ohta 63

Numerical Experiment for Ultrasonic-Measurement-Integrated Simulation of Developed Laminar Pipe Flow Using Axisymmetric Model Lei Liu Kenichi Funamoto Toshiyuki Hayase 71

The Effect of ATP on Force Relaxation of Isolated Actin Stress Fibers Exposed to Step Strain Tsubasa Matsui Shinji Deguchi Naoya Sakamoto Toshiro Ohashi Masaaki Sato 77

Development of an in vitro Tracking System for Catheter Motion Makoto Ohta Chang-Ho Yu Hiroyuki Kosukegawa Keisuke Mamada Kanju Kuroki Shinzo Oota Kazuto Takashima Kiyoshi Yoshinaka 83

Analysis of Changes in the Gliding Direction of Kinesin-Driven Microtubules Focusing on Their Length and KinesinDensity Shukei Sugita 91

Remodeling of Vascular Endothelial Cells Induced by Stretching Force Transmitted Through Intercellular Junctions Yosuke Ueki Naoya Sakamoto Toshiro Ohashi Masaaki Sato 99

Estimation of Unsteady Blood Flow Rate in Ultrasonic-Measurement-Integrated Simulation Takayuki Yamagata Toshiyuki Hayase 107

Section 2 Nano-Bioimaging 115

Structural Change of the Human Brain with Aging in Healthy Subjects-A Brain Magnetic Resonance Image (MRI) Study Hiroshi Fukuda Yasuyuki Taki Kentaro Inoue Shigeo Kinomura Kazunori Sato Ryoi Goto Ken Okada Ryuta Kawashima 117

Elasticity-Based Tissue Characterization of Arterial Wall Hideyuki Hasegawa Kentaro Tsuzuki Masataka Ichiki Fumiaki Tezuka Hiroshi Kanai 129

Radiologic Anatomy of the Right Adrenal Vein: Preliminary Experience with MDCT Shoki Takahashi Kei Takase Tomonori Matsuura 139

Potentials of Nano-Bio-Imaging with Positron Emission Tomography and Radiopharmaceuticals Manabu Tashiro Kazuhiko Yanai 147

High Intensity Focused Ultrasound Treatment Enhanced with Nano- to Micro-Particles Shin-Ichiro Umemura Shin Yoshizawa Kazuaki Sasaki Ken-Ichi Kawabata 161

Molecular Imaging and Its Application to Drug Development at Tohoku University Kazuhiko Yanai Nobuyuki Okamura Ren Iwata Manabu Tashiro 175

Molecular Imaging of Lymph Node Micrometastasis Using Contrast-Enhanced High-Frequency Ultrasonagraphy Li Li Kei Takase Shoki Takahashi 185

Evaluation of Exercise Induced Organ Energy Metabolism Using Two Analytical Approaches: A Pet Study Mehedi Masud Toshihiko Fujimoto Masayasu Miyake Shoiichi Watanuki Masatoshi Itoh Manabu Tashiro 195

Development of a New Positron Emission Mammography (PEM) Masayasu Miyake Seiichi Yamamoto Masatoshi Itoh Kazuaki Kumagai Takehisa Sasaki Targino Rodrigues Dos Santos Manabu Tashiro Mamoru Baba 201

Analysis of Anatomical Networks Using Regional Gray Matter Volume with Japanese Brain MRI Database Kai Wu Hiroshi Fukuda 207

Section 3 Nano-Biodevices 213

Passive Intelligent Walker Controlled by Servo Breaks Yasuhisa Hirata Kazuhiro Kosuge 215

New Objective Assessment of Acoustic Transfer Function via Patulous Eustachian Tube Using Time-Stretched Pulse Tetsuaki Kawase Yoko Hori Yasushi Baba Toshimitsu Kobayashi Shuichi Sakamoto Y&ohat;ichi Suzuki 225

Miniaturized Microfluidic Biofuel Cells Matsuhiko Nishizawa 235

Development of an Endoscopic Tactile Sensor Using PVDF Films Mami Tanaka Takeshi Okuyama Mikiko Sone Yoshikatsu Tanahashi Seiji Chonan 245

Development of a Fully Implantable Retinal Prosthesis with a Three-Dimensionally Stacked Large-Scale Integrated Circuit Tetsu Tanaka Takafumi Fukushima Mitsumasa Koyanagi 255

Visualization of Ion Distribution by a Chemical Imaging Sensor Tatsuo Yoshinobu Ko-Ichiro Miyamoto Shin'ichiro Kanoh Torsten Wagner Michael J. Schöet;ning 271

A Car Transportation System with Multiple Robots: iCART Mitsuru Endo Kenji Hirose Yasuhisa Hirata Kazuhiro Kosuge Koki Suzuki Takashi Kanbayashi 281

A Photoreceptive Stimulator for a Retinal Prosthesis with 3D Stacked LSI Kouji Kiyoyama Keigo Sato Yoshiyuki Kaiho Hiroshi Tomita Eriko Sugano Takafumi Fukushima Hiroyuki Kurino Tetsu Tanaka Mitsumasa Koyanagi 289

Development of a Silicon Neural Probe for an Intelligent Silicon Neural Probe System Risato Kobayashi Lee Sanghoon Soichiro Kanno Bea Jicheol Takafumi Fukushima Kazuhiro Sakamoto Norihiro Katayama Hajime Mushiake Tetsu Tanaka Mitsumasa Koyanagi 297

Evoked Potentials in Response to Electrical Stimulation of the Cochlear Nucleus by Means of Multi-Channel Surface Microelectrodes Kiyoshi Oda Tetsuaki Kawase Daisuke Yamauchi Hiroshi Hidaka Toshimitsu Kobayashi 309

Development of a Tactile Sensor for Evaluation of Detergents Daisuke Tsuchimi Mami Tanaka 315

Section 4 Nano-Biointervention 325

Noncontact Manipulation of Micro-Nano Scale Biological Objects in a Chip Using Integrated Optical Tweezers and Microtools Fumihito Arai Hisataka Maruyama Toshio Fukuda 327

On-Chip Cell Manipulation with Magnetically Driven Microtools Fumihito Arai Yoko Yamanishi 333

Analysis of Tumor Suppressor Gene Using Molecular Imaging for Personalized Medicine Natsuko Chiba Leizhen Wei 339

Development of a Transcutaneous Energy Transmission System for Advanced Medical Applications Kentaro Kato Kota Shinohe Tetsuya Takura Fumihiro Sato Hidetoshi Matsuki 351

Development of Bio-Imaging with Functional Nano-Objects Noriaki Ohuchi Masaaki Kawai Yuu Sakurai Hideo Higuchi Yoshio Kobayashi Kohsuke Gonda Motohiro Takeda 361

Development of the Various Kinds of Artificial Organs and Clinical Application of the New Diagnosis Tool Tomoyuki Yambe 373

Pulse Diagnosis Machine and Autogenic Training Tomoyuki Yambe 387

Detection Algorithm of Fatal Arrhythmias for Implantable Cardioverter Defibrillators Using Joint Probability Makoto Yoshizawa Hiroyuki Kinoshita Kazuo Shimizu Masashi Inagaki Kazunori Uemura Masaru Sugimachi Kenji Sunagawa 399

Quantitative Evaluation of Effects of Visually Induced Motion Sickness Using Photoplethysmography Makoto Abe Makoto Yoshizawa Norihiro Sugita Akira Tanaka Shigeru Chiba Tomoyuki Yambe Shin-Ichi Nitta 411

Sentinel Lymph Node Biopsy and Mapping by Silica-Coated Fluorescent Beads Liman Cong Motohiro Takeda Mika Watanabe Yoshio Kobayashi Masaki Kobayashi Noriaki Ohuchi 421

In vivo Real-Time Tracking of Single Particle in Tumors of Mice Yohei Hamanaka Masaaki Kawai Kohsuke Gonda Motohiro Takeda Noriaki Ohuchi 427

Analysis of Power Spectrum and Fractal Dimension During Undulation Pump Ventricular Assistance Hongjian Liu Yasuyuki Shiraishi Xiumin Zhang Yun Luo Tomoyuki Yambe 433

Fabrication of Transparent Arteriole Membrane Models Takuma Nakano Seiichi Ikeda Toshio Fukuda Takehisa Matsuda Makoto Negoro Fumihito Arai 441

Achievement of Mechanical Assistance by an Artificial Myocardium Using Shape Memory Alloy Fibre Yasuyuki Shiraishi Tomoyuki Yambe Dai Homma 449

Analysis of BRCA1 Accumulation at DNA Double-Strand Breaks Using a Molecular Imaging Technique Leizhen Wei Natsuko Chiba 459

Author Index 467