Table of Contents
Section I Lifestyle-Related Diseases, and Free Radicals and Their Protection
Chapter 1 Redox Regulation as an Underlying Factor in Health and Disease Junji Yodoi Norihiko Kondo Yasuyuki Ishii Junko Sakakura Hajime Nakamura 3
Chapter 2 Diet and Lifestyle in Cancer Prevention David Heber 11
Chapter 3 The Gene Regulatory Mechanism of Thioredoxin and Thioredoxin Binding Protein-2/VDUP1 in Cancer Prevention Hiroshi Masutani Yumiko Nishinaka Yong-Chul Kim Junji Yodoi 25
Chapter 4 Coenzyme Q10, Free Radicals, and Heart Disease Yorihiro Yamamoto 37
Chapter 5 Wine, Alcohol, and a Healthy Heart Dipak K. Das Nilanjana Maulik 47
Chapter 6 Diabetes Treatment by Alpha-Lipoic Acid: Modulation of Glucose Uptake and Adipocyte Differentiation An-Sik Chung Kyung-Joo Cho Hadi Moini Lester Packer 63
Chapter 7 The Mechanism of Immune Suppression by GIF and Cysteinylated MIF at Cys-60 Yasuyuki Ishii Aoi Son Norihiko Kondo Junko Sakakura-Nishiyama Yoshiyuki Matsuo Junji Yodoi 77
Chapter 8 Role of Free Radicals in Cellular Damage and Its Modification by Antioxidants: Implications for Cancer Therapy K.P. Mishra 87
Chapter 9 Free Radicals, Cigarette Smoke, and Health Scavenging Effects of Pycnogenol® on Free Radicals Generated from Cigarette Smoke and Its Detoxification Effects Baolu Zhao 93
Section II Brain Diseases, and Free Radicals and Their Protection
Chapter 10 Free Radical Scavengers and Neuroprotection Midori Hiramatsu 107
Chapter 11 Oxidative Adaptation in Aging and Alzheimer's Disease: The Roles of Amyloid and Tau Hyoung-gon Lee Xiongwei Zhu Kelly L. Drew James A. Joseph Akihiko Nunomura Keisuke Hirai Atsushi Takeda George Perry Mark A. Smith 117
Chapter 12 Coenzyme Q10 Stabilizes Mitochondria in Parkinson's Disease Manuchair Ebadi Sawitri Wanpen Shaik Shavali Sushil Sharma Hesham El ReFaey 127
Chapter 13 The In Vitro and In Vivo Molecular Mechanisms of Neuroprotection by the Major Green Tea Polyphenol, (-)-Epigallocatechin-3-gallate, with Special Reference to Parkinson's Disease Orly Weinreb Silvia Mandel Tamar Amit Moussa B.H. Youdim 155
Chapter 14 Kainic-Acid-Induced Neurotoxicity: Involvement of Free Radicals Akitane Mori Toshiki Masumizu Isao Yokoi Lester Packer 175
Chapter 15 Prevention of Cerebral Oxidative Stress Using Traditional Chinese Medicines: A Model of Antioxidant-Based Composite Formula Tetsuya Konishi 189
Chapter 16 Analysis of the Oxidative Stress State in Disease Development of Senescence-Accelerated Mouse Seiichi Matsugo Fumihiko Yasui Kazuo Sasaki 197
Section III Nutraceuticals, Functional Foods, Micronutrients, and Pharmacological Interventions
Chapter 17 The Antioxidant Evolution: From Free Radical Scavenging to the Antioxidant Network and Gene Regulation by Flavonoids and Bioflavonoid-Rich Extracts from Pine Bark and Gingko Biloba Leaf Lester Packer 205
Chapter 18 New Horizons in Vitamin E Research Etsuo Niki 217
Chapter 19 Gastrointestinal Inflammatory Diseases: Role of Chemokine Toshikazu Yoshikawa Yuji Naito 225
Chapter 20 Oxidative Stress Involvement in Diabetic Nephropathy and Its Prevention by Astaxanthin Yuji Naito Kazuhiko Uchiyama Toshikazu Yoshikawa 235
Chapter 21 Preventive and Therapeutic Effects of Plant Polyphenols through Suppression of Nuclear Factor-Kappa B Navindra P. Seeram Haruyo Ichikawa Shishir Shishodia Bharat B. Aggarwal 243
Chapter 22 Ascorbic Acid and Oxidative Damage to DNA: Interrelationships and Possible Relevance to Lifestyle-Related Diseases I.F.F. Benzie C.K. Chan S.W. Choi Y.T. Szeto 277
Chapter 23 The Role of Lipid Peroxidation in Chromosomal DNA Fragmentation Associated with Cell Death Induced by Glutathione Depletion Yoshihiro Higuchi Hideji Tanii Yuji Mizukami Tanihiro Yoshimoto 287
Chapter 24 Antioxidant Properties of Select Indian Medicinal Plants in Relation to Their Therapeutic Effects J.C. Tilak S. Adhikari B. Lakshmi K.K. Janardhanan T.P.A. Devasagayam 303
Chapter 25 Antioxidant Activity of Tendai-Uyaku Extract Toshiki Masumizu Takao Kaneyuki Akitane Mori 319
Chapter 26 Detection of Active Oxygen Species in the Decomposition Process of Peroxovanadium (V) Complexes Seiichi Matsugo Shingo Hayakawa Chie Mihara Kan Kanamori 327
Chapter 27 Structural Determination and Antioxidative Activity of Oxidation Products of Flavonoids with Reaction Oxygen Species Yuko Hirose Toshiyuki Washizu Yuzo Uchida Seiichi Matsugo 333
Chapter 28 Reactivity of Anthocyanin toward Reactive Oxygen and Reactive Nitrogen Species Takashi Ichiyanagi Yoshihiko Hatano Seiichi Matsugo Tetsuya Konishi 339
Index 347
