Methods in Pharmacology: Molecular and Cellular Biology of Pharmacological Targets / Edition 1

by H. Glossmann, J. Striessnig

Overview

The current volume provides detailed experimental prools used to study plasma membrane ion channels as pharmacological targets. Coverage includes molecular and biochemical characterization of ion channels; fuctional analysis of ion channels after reconstitution, expression, or in cells; and specific methods and tools. This wealth of information will benefit academic and industrial researchers and graduate students in pharmacology, biochemistry, physiology, and biophysics.

Product Details

ISBN-13:	9780306444241
Publisher:	Springer US
Publication date:	09/30/1993
Series:	Methods in Pharmacology Series , #7
Edition description:	1993
Pages:	278
Product dimensions:	7.01(w) x 10.00(h) x 0.28(d)

Table of Contents

Molecular and Biochemical Characterisation of Ion Channels: Purification and Pharmacologic Analysis of the OmegaConotoxin Receptor from Rat Brain (M. McEnery). Molecular Characterization of the CharybdotoxinSensitive, High Conductance, Calcium Activated Potassium Channel (M. GarciaCalco et al.). Functional Analysis of Ion Channels: Xenopus Oocytes as an Expression System for Ion Channels (A.L. Goldin). Reconstitution of Muscle Calcium Channel Function in Bilayer Membranes (D.J. Pelzer et al.). Specific Methods and Tools: Production of Monoclonal Antibodies Against Low Abundance, Ion Channel Associated Proteins in Neuronal Tissue (M. Takahashi). A Highly Porous Sodium DodecylsulfatePolyacrylamide System (J.P. Doucet et al.). Synthesis and Properties of Diazipine, a Novel Photoaffinity Probe for Calcium ChannelLinked DHP Receptors (H. Nakayama et al.). 4 additional articles. Index.

Editorial Reviews

Specialists in the field of ion channels provide an in-depth view of current biochemical and electrophysiological methods, focusing on the cation-selective ion channels that are of special pharmacological interest. Discusses the molecular and biochemical characterization of ion channels, the functional analysis of ion channels (after reconstitution or expression, or in cells), and several specific methods and tools. Annotation c. Book News, Inc., Portland, OR (booknews.com)

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