Leishmaniasis: The Current Status and New Strategies for Control: Proceedings of the NATO Advanced Study Institute, Zakynthos (Greece), 1987 / Edition 1

by D.T. Hart

Overview

V Pentostam, an uncharacterized complex of Sb and carbohydrate derived from gluconic acid, is concentrated by Leishmania amastigotes via protein binding. Biochemical consequences of the interaction of amastigotes with Pentostam are inhibition of parasite bioenergetics and inhibition of ATP synthesis. REFERENCES 1. J.C. Mottram and G.H. Coombs. Enzyme activities of amastigotes and promastigotes and their inhibition by antimonials and arsenicqls. Exper. Parasitol. 59:151 (1985). 125 2. S.L. Croft, K.D. Neame and C.A. Homewood. Accumulation of [ Sb] sodium stibogluconate by Leishmania mexicana amazonensis and Leishmania donovani in vitro. Compo Biochem. Physiol. 68c:95 (1981). 3. J.D. Berman, J.V. Gallalee, and B.D. Hansen. Leishmania mexicana: uptake of sodium stibogluconate (Pentostam) and pentamidine by parasite and macrophages. Exper. Parasitol. 64:127 (1987). 4. J.D. Berman, D. Waddell and B.D. Hanson. Biochemical meChanisms of the antileishmanial activity of sodium stibogluconate. Antimicrobial Agents Chemotherapy. 27:916 (1985). 5. J.D. Berman, J.V. Gallalee, and J.M. Best. Sodium stibogluconate (Pentostam) inhibition of glucose catabolism via the glycolytic pathway, and fatty acid B-oxidation in Leishmania mexicana amastigotes. Biochem. Pharmacol. 36:197 (1987). 6. D.T. Hart and G.H. Coombs. Leishmania mexicana: Energy metabolism of amastigotes and promastigotes. Exper. Parasitol. 54:397 (1982). 478 EFFECTS OF SINEFUNGIN ON CELLULAR AND BIOCHEMICAL EVENTS IN PROMASTIGOTES OF LEISHMANIA d. donovani Fran~oise Lawrence, and MaIka Robert-Cero Institut de Chimie des Substances Naturelles C.N.R.S.

Product Details

ISBN-13:	9780306431463
Publisher:	Springer US
Publication date:	08/01/1989
Series:	NATO Science Series A: , #11
Edition description:	1989
Pages:	1041
Product dimensions:	7.01(w) x 10.00(h) x 0.09(d)

Editorial Reviews

Leishmaniasis is a tropic and subtropical disease affecting humans and other mammals, discovered 100 years ago, and known to be spread by the sand flea. The conference lecture sessions are a topical compendium of the most pertinent aspects of recent research and provide a focus for future research in the area of control. The workshop summaries deal with several controversial or equivocal topics, clarifying rather than resolving issues. Includes a report of the field trip made on the island during the conference. Contains a total of nearly 300 papers. Annotation c. Book News, Inc., Portland, OR (booknews.com)

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