In Vitro Neurotoxicology: Principles and Challenges / Edition 1

by Evelyn Tiffany-Castiglioni

Overview

Well-respected leaders in the field of in vitro neurotoxicology take a fresh look at their own and other's work, critically and comparatively analyzing it across experimental systems and toxicants, and synthesizing essential principles for in vitro neurotoxicity testing. Neurotoxicants of significance to human health are emphasized, especially those for which metabolism and dose-responses are well well studied both in vivo and in vitro: lead, mercury, organophosphorous insecticides, polychlorinated biphenyls and dioxin, ethanol, and endogenous proteins. The goal is to set out new concepts and research directions that will hasten significant improvement in the methods and systems for in vitro neurotoxicity testing.

Product Details

ISBN-13:	9781617373237
Publisher:	Springer-Verlag New York, LLC
Publication date:	11/09/2010
Series:	Methods in Pharmacology and Toxicology
Edition description:	Softcover reprint of hardcover 1st ed. 2004
Pages:	331
Product dimensions:	5.98(w) x 9.02(h) x 0.03(d)

Table of Contents

In Vitro Neurotoxicology.- Predictive Value of In Vitro Systems for Neurotoxicity Risk Assessment.- Exposure-Dose-Response Paradigm as It Relates to Toxicogenomics.- In Vitro Studies of Neurotoxicant Effects on Cellular Homeostasis.- Role of Apoptosis in Neurotoxicology.- Impairment of Neurotransmitter Metabolism and Function by Neurotoxicants.- Cell-Type Specific Responses of the Nervous System to Lead.- Effects of Toxicants on Neural Differentiation.- Impairment of Synaptic Function by Exposure to Lead.- Aggregating Brain Cell Cultures for Neurotoxicological Studies.- Use of Complimentary In Vitro and In Vivo Methods for Assessing Neuroendocrine Disruptors.- Establishing In Vitro Models to Study Endogenous Neurotoxicants.

Editorial Reviews

"This book covers a wide range of topics, starting with a nice overview of the field of neurotoxicology. Moving on to the meat of the material, the effects of toxins on neural development, function, and degeneration are examined, using well studied neurotoxicants as examples. A thorough list of articles as well as an annotated reading list are valuable additions, making the book an excellent reference. This is a valuable reference for anyone studying the advances in neurotoxicology. It is concise and easy to comprehend, without sacrificing quality in the process. It is written by leaders in the field, ensuring the information is relevant and up-to-date."-Doody's Health Sciences Book Review Journal

"This is a useful book that updates new an improved in vitro methods to help further understanding neurotoxicology. The information presented is exciting, the methods proposed are often innovative, and readers will find a challenging glimpse into the future contributions their own research efforts can generate. Neurotoxicologists will find studying this volume rewarding and inspiring." - Vet Human Toxicol

"...a helpful and up to date book..." - BTS Newsletter

From the Publisher

Reviewer: Timothy A. Park, Predoc in Neurotoxicology(Oregon State University)
Description: This book explores the difficulties in researching neurotoxicology and looks at new techniques and models that can be used to better study this field.
Purpose: The purpose is to combine principles and concepts of neurotoxicology to better develop methods and models. This aspiration is important so that experiments better parallel real-life situations. This book does a thorough job of exploring new technologies and models, and how these can be used to advance neurotoxicology. It also provides a valuable list of other articles on the subject, making this book a great reference.
Audience: Graduate students in neurotoxicology who are learning about the field, new researchers looking for models to use in their research, and long standing leaders in the field searching for better methods that more closely mirror real-life situations are the intended audience. As a predoctorate in neurotoxicology, I was able to understand and learn a great deal from this book.
Features: This book covers a wide range of topics, starting with a nice overview of the field of neurotoxicology. Moving on to the meat of the material, the effects of toxins on neural development, function, and degeneration are examined, using well studied neurotoxicants as examples. A thorough list of articles as well as an annotated reading list are valuable additions, making the book an excellent reference.
Assessment: This is a valuable reference for anyone studying the advances in neurotoxicology. It is concise and easy to comprehend, without sacrificing quality in the process. It is written by leaders in the field, ensuring the information is relevant and up-to-date.

Doody's Review Service