Human Biological Aging: From Macromolecules to Organ Systems / Edition 1

by Glenda E. Bilder

Overview

Comprehension of the theories of aging requires rudimentary knowledge of oxidation and reduction reactions, protein function, cell organelles, mitosis, acquired immunity, and evolution, among other basic biological concepts.  Without these fundamentals, students of biological aging struggle to learn the essentials of biological aging and how to appreciate the research advances in the field.

Human Biological Aging: From Macromolecules To Organ-Systems is an introduction to human aging from the level of macromolecules to organ systems. Age changes in proteins, DNA, polysaccharides and lipids are discussed relative to known age-related alterations in structure and function produced by free radicals and oxidants.  At the cellular level, age-dependent mechanisms that diminish organelle function are described.  Cellular phenomena of replicative senescence apoptosis, autophagy and neuroplasticity are detailed as to their contribution to compromised cellular functions. 

Authored by a leader in the field, Human Biological Aging: From Macromolecules To Organ-Systems is an invaluable introduction for those studying human aging.

Product Details

ISBN-13:	9781118967027
Publisher:	Wiley
Publication date:	04/04/2016
Pages:	344
Product dimensions:	6.60(w) x 9.50(h) x 0.70(d)

About the Author

Glenda E. Bilder is an Instructor at Gwynedd Mercy College in Gwynedd Valley, PA, USA.

Table of Contents

Preface vii

About the Companion Website ix

Section I THE FOUNDATION 1

1 ORIENTATION 3

2 MEASUREMENTS AND MODELS 17

3 EVOLUTIONARY THEORIES OF AGING 35

Section II BASIC COMPONENTS 47

4 AGING OF MACROMOLECULES 53

5 AGING OF CELLS 77

Section III ORGAN SYSTEMS: OUTER COVERING AND MOVEMENT: INTEGUMENTARY, SKELETAL MUSCLES, AND SKELETAL SYSTEMS 101

6 AGING OF THE INTEGUMENTARY SYSTEM 103

7 AGING OF THE SKELETAL MUSCLE SYSTEM 123

8 AGING OF THE SKELETAL SYSTEM 143

Section IV INTERNAL ORGAN SYSTEMS: CARDIOVASCULAR, PULMONARY, GASTROINTESTINAL, AND URINARY SYSTEMS 163

9 AGING OF THE CARDIOVASCULAR SYSTEM 165

10 AGING OF THE PULMONARY SYSTEM 193

11 AGING OF THE GASTROINTESTINAL AND URINARY SYSTEMS 207

Section V REGULATORY ORGAN SYSTEMS: CENTRAL NERVOUS SYSTEM, SENSORY, ENDOCRINE, AND IMMUNE SYSTEMS 223

12 AGING OF THE CENTRAL NERVOUS SYSTEM 225

13 AGING OF THE SENSORY SYSTEM 255

14 AGING OF THE ENDOCRINE SYSTEM 275

15 AGING OF THE IMMUNE SYSTEM 303

Index 323