Herpesviruses and Immunity / Edition 1

by Peter G. Medveczky, Herman Friedman, Mauro Bendinelli

Overview

Although virology and immunology are now considered separate disciplines, history shows that these areas ofinvestigation always overlapped and one cannot really exist without the other. This trend has become particularly significant and fruitful in the past few years in the area of herpesvirus research. The genomes of the most important herpesviruses have been sequenced, a significant portion of their genes have been identified, and many secrets of regulation of gene expr- sion have been unraveled. Now this progress sets the stage for a true revolution in herpesvirus research: analysis of interactions between the host and the virus. Because herpesviruses can induce, suppress, and fool the immune system, the most productive herpesvirologists are also expert immunologists, and the current results ofthis interdisciplinary effort are truly remarkable. Because herpesviruses cause many important human diseases, the devel- ment of vaccines against these agents is a very significant goal. This effort is also very challenging because of the complexity of herpesviruses and the lack of sufficient information about immune responses. The remarkable ability of herpesviruses to escape immune responses is - other feature that brings immunology and virology together. Herpesviruses - code many proteins that interact with and down-regulate some key elements of the immune system. Thisproperty of herpesviruses represents amajor challenge in developing strategies against these viruses. On the positive side, these viral proteins also provide novel tools for analyzing specific immune reactions and molecular mechanisms.

Product Details

ISBN-13:	9780306458903
Publisher:	Springer US
Publication date:	10/31/1998
Series:	Infectious Agents and Pathogenesis
Edition description:	2002
Pages:	317
Product dimensions:	5.98(w) x 9.02(h) x 0.35(d)

About the Author

Medveczky, Peter G. (Univ of South Florida); Friedman, Herman (Univ of South Florida); Bendinelli, Mauro (Univ of Pisa)

Table of Contents

Evasion and Obstruction.- Immunopathology of Herpesvirus Infections.- HSV Gene Expression during Latent Infection and Reactivation.- T Cell Activation and Lymphokine Induction in Herpesvirus saimiri Immortalized Cells.- Kaposi’s Sarcoma-Associated Herpesvirus (KSHV/HHV8) and the Etiology of KS.- Immunobiology of Murine Gamma Herpesvirus-68.- EBV and B Cell Lymphomas.- Immune Responses to Epstein-Barr Viral Infection.- EBV Persistence in Vivo.- Epstein-Barr Virus Vaccines.- Inhibition of MHC Class I Function by Cytomegalovirus.- Cell-Mediated Immunity against Varicella-Zoster Virus.- Complement Control Proteins of Rhadinoviruses.

Editorial Reviews

Reviewer: Nigel Bourne, PhD (The University of Texas Medical Branch)
Description: This book is an addition to the series Infectious Agents and Pathogenesis. Issues addressed include immune evasion, latency and reactivation, and immunopathology. Particular emphasis is given to recent developments in the field and the chapters are well supplied with references to aid further study.
Purpose: The editors have assembled a collection of reviews authored by an impressive list of researchers in the field. These reviews provide concise overviews of different aspects of interactions between the herpesviruses and the host immune system.
Audience: It is for immunologists and virologists, including pre- and post-doctoral students and their mentors. While this is an extensive target audience, most should find something of interest in this volume.
Features: This book features interactions between herpesviruses and the immune system. It includes a number of reviews of various areas of this research. The content is up-to-date and well referenced. Although the chapters are well written and informative, the figures are somewhat basic, and some chapters would have been improved by the inclusion of additional figures to illustrate key points.
Assessment: The book carries a hefty price tag for what is a relatively slim volume, which may discourage some potential customers. Despite minor flaws, it provides a welcome addition to the field with a series of overviews providing lucid accounts of our current understanding of the interaction of these viruses and the host immune system. It is well worth reading.

Doody's Review Service

Reviewer: Nigel Bourne, PhD(The University of Texas Medical Branch)
Description: This book is an addition to the series Infectious Agents and Pathogenesis. Issues addressed include immune evasion, latency and reactivation, and immunopathology. Particular emphasis is given to recent developments in the field and the chapters are well supplied with references to aid further study.
Purpose: The editors have assembled a collection of reviews authored by an impressive list of researchers in the field. These reviews provide concise overviews of different aspects of interactions between the herpesviruses and the host immune system.
Audience: It is for immunologists and virologists, including pre- and post-doctoral students and their mentors. While this is an extensive target audience, most should find something of interest in this volume.
Features: This book features interactions between herpesviruses and the immune system. It includes a number of reviews of various areas of this research. The content is up-to-date and well referenced. Although the chapters are well written and informative, the figures are somewhat basic, and some chapters would have been improved by the inclusion of additional figures to illustrate key points.
Assessment: The book carries a hefty price tag for what is a relatively slim volume, which may discourage some potential customers. Despite minor flaws, it provides a welcome addition to the field with a series of overviews providing lucid accounts of our current understanding of the interaction of these viruses and the host immune system. It is well worth reading.

This book is an addition to the series Infectious Agents and Pathogenesis. Issues addressed include immune evasion, latency and reactivation, and immunopathology. Particular emphasis is given to recent developments in the field and the chapters are well supplied with references to aid further study. The editors have assembled a collection of reviews authored by an impressive list of researchers in the field. These reviews provide concise overviews of different aspects of interactions between the herpesviruses and the host immune system. It is for immunologists and virologists, including pre- and post-doctoral students and their mentors. While this is an extensive target audience, most should find something of interest in this volume. This book features interactions between herpesviruses and the immune system. It includes a number of reviews of various areas of this research. The content is up-to-date and well referenced. Although the chapters are well written and informative, the figures are somewhat basic, and some chapters would have been improved by the inclusion of additional figures to illustrate key points. The book carries a hefty price tag for what is a relatively slim volume, which may discourage some potential customers. Despite minor flaws, it provides a welcome addition to the field with a series of overviews providing lucid accounts of our current understanding of the interaction of these viruses and the host immune system. It is well worth reading.

Nigel Bourne

Virologists and immunologists working with herpesvirus summarize their work and some of the newer developments in its study, especially in areas the two disciplines overlap, and in light of the now nearly completed mapping of the virus' genome. Their topics include the central strategy of the interaction of human herpesviruses with host defenses, T cell activation and lymphokine induction in Herpesvirus saimiri immortalized cells, the immunobiology of murine gamma herpesvirus-68, immune responses to Epstein-Barr viral infection, cell-mediated immunity against Varicella-Zoster virus, and complement control proteins of Rhadinoviruses. Annotation c. by Book News, Inc., Portland, Or.

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