Hematology: Basic Principles and Practice, Expert Consult - Online and Print / Edition 5

by Ronald Hoffman MD, Bruce Furie MD, Philip McGlave MD, Leslie E. Silberstein MD, Sanford J. Shattil MD

Overview

This leading text reflects both the new direction and explosive growth of the field of hematology. Edited and written by practitioners who are the leaders in the field, the book covers basic scientific foundations of hematology while focusing on its clinical aspects. This edition has been thoroughly updated and includes ten new chapters on cellular biology, haploidentical transplantation, hematologic manifestations of parasitic diseases, and more. The table of contents itself has been thoroughly revised to reflect the rapidly changing nature of the molecular and cellular areas of the specialty. Over 1,000 vivid images, now all presented in full color for the first time, include a collection of detailed photomicrographs in every chapter, selected by a hematopathology image consultant. What's more, this Expert Consult Edition includes access to the complete contents of the book online, fully searchable.

• A multidisciplinary approach from a unique team of specialists delivers well-rounded guidance on every topic.
• "Red boxes" present the authors' unique personal strategies for diagnosis and treatment.
• An intuitively re-designed table of contents makes information easier than ever to find.
• Online access allows you to rapidly search the entire contents of the book.

• Ten cutting-edge new chapters - on cellular biology, haploidentical transplantation, hematologic manifestations of parasitic diseases, and more - keep you completely current.
• More than 1,000 vibrant images, all presented in full color for the first time, include a collection of detailed photomicrographs in several chapters selected by a hematopathology image consultant.
• An enhanced clinical focus makes actionable information easier to find and apply.
• Enhanced coverage of pediatric hematology reflects the supervision of new section editor Helen Heslop, MD, FRCPA, FRACP.

Product Details

ISBN-13:	9780443067150
Publisher:	Elsevier Health Sciences
Publication date:	10/30/2008
Edition description:	Older Edition
Pages:	2560
Product dimensions:	8.80(w) x 11.10(h) x 2.70(d)

About the Author

Table of Contents

Part I. MOLECULAR AND CELLULAR BASIS OF HEMATOLOGY

Chapter 1 Anatomy and Physiology of the Gene

Edward J. Benz, Jr., Andrew Wagner, Nancy Berliner

Chapter 2 Genomic Approaches to the Study of Hematologic Science

Todd Golub and Scott Armstrong

Chapter 3 Protein Synthesis, Processing, and Degradation

Garabet G. Toby and David L. Wiest

Chapter 4 Protein Architecture: Relationship of Form and Function

Alan C. Rigby and Barbara C. Furie


Chapter 5 Regulation of Cellular Response


Benjamin G. Neel and Christopher Carpenter

Chapter 6 Cell Adhesion

Rodger P. McEver

Chapter 7 Control of Cell Division

William M.F. Lee and Chi V. Dang

Chapter 8 Cell Death

David M. Hockenbery and Stanley J. Korsmeyer

Chapter 9 Pharmacogenomics and Hematological Diseases

Loe Kager and William E. Evans

Part II. IMMUNOLOGIC BASIS OF HEMATOLOGY


Chapter 10 Overview and Compartmentalization of the Immune System

Leland D. Powell and Linda G. Baum

Chapter 11 B-Cell Development

Kenneth Dorshkind and David J. Rawlings

Chapter 12 T-Cell and NK-Cell Immunity

Carol Clayberger and Alan M. Krensky

Chapter 13 Dendritic Cell Biology

Zbigniew M. Szczepiorkowski and Nina Bhardwhaj

Chapter 14 Regulation of Activation of B and I Lymphocytes

John C. Monroe and Lawrence Turka

Chapter 15 Leukocyte Trafficking

James J. Campbell, Steven Sloan, and Leslie E.Silberstein

Chapter 16 Tolerance and Autoimmunity

Mark J. Shlomchik

Part III. BIOLOGY OF STEM CELLS AND DISORDERS OF HEMATOPOIESIS

Chapter 17 Stem Cell Model of Hematopoiesis

Anskar YH Leung and Catherine M. Verafaillie

Chapter 18 Bone Marrow Microenvironment

Mo Dao and Catherine M. Verfaillie

Chapter 19 The Humeral Regulation of Hematopoiesis

Montaser Shaheen and Hal Broxmeyer

Chapter 20 Biology of Erythropoiesis, Erythroid Differentiation, and Maturation

Thalia Papayannopoulou, Alan D'Andrea, Janis Abkowitz, and Anna Rita Migliaccio

Chapter 21 Granulopoiesis and Monocytopoiesis

Arati Khanna-Gupta and Nancy Berliner

Chapter 22 Thrombocytopoiesis

Michael W. Long and Ronald Hoffman

Chapter 23 Thrombocytopenia Due to Decreased Platelet Production

J. B. Opalinska and Alan M. Gewirtz

Chapter 24 Inherited Forms of Bone Marrow Failure

Melvin H. Freedman

Chapter 25 Aplastic Anemia

Neal S. Young and Jaroslaw P. Maciejewski

Chapter 26 Paroxysmal Nocturnal Hemoglobinuria

Rob A. Brodsky

Chapter 27 Pure Red Cell Aplasia

Emmanuel N. Dessypris

Part IV. RED BLOOD CELLS

Chapter 28 Pathobiology of the Human Erythrocyte and Its Hemoglobins

Martin H. Steinberg, Edward J. Benz, Jr., Henry Adewoye, and Ben Ebert

Chapter 29 Approach to Anemia in the Adult and Child

Peter Marks and Bertil Glader

Chapter 30 Anemia of Chronic Diseases

Lawrence B. Gardner and Edward J. Benz, Jr.

Chapter 31 Pathology of Iron Metabolism

Nancy C. Andrews

Chapter 32 Disorders of Iron Metabolism
: Iron Deficiency and Overload

Gary M. Brittenham

Chapter 33 Heme Biosynthesis and Its Disorders: Porphyrias and Sideroblastic Anemias

James S. Wiley and Michael R. Moore

Chapter 34 Megablastic Anemias

AÅ“ok C. Anthony

Chapter 35 Thalassemia Syndromes

Bernard G. Forget and Alan R. Cohen

Chapter 36 Pathology of Sickle Cell Disease

Robert P. Hebbel

Chapter 37 Sickle Cell Disease

Stephen H. Embury, Elliot Vichinsky, and Yogen Saunthararajah

Chapter 38 Hemoglobin Variants Associated with Hemolytic Anemia, Altered Oxygen Affinity, and

Methemoglobinemias

Edward J. Benz, Jr.

Chapter 39 Red Cell Enzymopathies

Xylina T. Gregg and Josef T. Prchal

Chapter 40 Red Cell Membrane Disorders

Patrick G. Gallagher and Petr Jarolim

Chapter 41 Autoimmune Hemolytic Anemias

Melody J. Cunningham and Leslie E. Silberstein

Chapter 42 Extrinsic Nonimmune Hemolytic Anemias

Stanley L. Schrier and Erin Gourley Reid


Part V. HOST DEFENSE AND ITS DISORDERS

Chapter 43 Complement Biology and Immunoglobulin

Gregory Kline, Robert Barrington, and Michael C. Carroll


Chapter 44 Normal Phagocyte Structure and Function

Robert L. Baehner

Chapter 45 Eosinophilia, Eosinophil-Associated Diseases, Chronic Eosinophil Leukemia, and the Hypereosinophilic Syndromes

Steven J. Ackerman and Joseph H. Butterfield

Chapter 46 Disorders of Phagocyte Function and Number

Mary C. Dinauer and Thomas D. Coates

Chapter 47 Disorders of Lymphocyte Function

Aileen M. Cleary, Richard A. Insel, and David B. Lewis

Chapter 48 Histiocytic Disorders

Jeffrey M. Lipton and Robert J. Arceci

Chapter 49 Lysosomal Storage Diseases: Perspective and Principles

Gregory A. Grabowski and Nancy Leslie

Chapter 50 Infectious Mononucleosis and Other Epstein-Barr Virus-Associated Diseases

Stephen Gottschalk, Cliona M. Rooney, and Helen E. Heslop


Chapter 51 The Spleen and Its Disorders

Susan B. Shurin

Chapter 52 Basophils, Mast Cells, and Systemic Mastocytosis

Robert I. Parker and Dean D. Metcalfe

Part VI. HEMATOLOGIC MALIGNANCIES

Chapter 53 Conventional Cytogenetics and Molecular Cytogenetics in Hematological

Malignancies
Gordon Dewald and Rhett P. Ketterling

Chapter 54 The Molecular Basis of Neoplasia

Carol Westbrook

Chapter 55 Pharmacology and Molecular Mechanisms of Antineoplastic Agents for Hematologic Malignancies

Stanton Gerson, Kapil N. Bhalla, Steven Grant, Richard Creeger, Nizar Bahlis

Chapter 56 Radiation Therapy in the Treatment of Hematologic Malignancies

Andrea K. Ng and Peter M. Mauch

Chapter 57 Clinical Use of Hematopoietic Growth Factors

Jacob M. Rowe and Irit Avivi

Chapter 58 Radioimmunotherapy for B-Cell and Non-Hodgkin Lymphoma


Thomas E. Witzig

Chapter 59 Pathobiology of Acute Myeloid Leukemia

Brian Huntly and D. Gary Gilliland

Chapter 60 Clinical Manifestations of Acute Myeloid Leukemia

Kenneth B. Miller and Philip R. Daoust

Chapter 61 Therapy for Acute Myeloid Leukemia

Elihu H. Estey and Hagop Kantarijan

Chapter 62 Acute Myeloid Leukemia in Children

Gary V. Dahl and Howard J. Weinstein

Chapter 63 Pathobiology of Acute Lymphoblastic Leukemia

A. Thomas Look and Adolpho Ferrando

Chapter 64 Clinical Manifestations of Acute Lymphoblastic Leukemia

Stacey L. Berg, C. Philip Steuber, and David G. Poplack

Chapter 65 Treatment of Childhood Acute Lymphoblastic Leukemia

Lewis B. Silverman, Stephen E. Sallan, and Harvey J. Cohen

Chapter 66 Acute Lymphoblastic Leukemia in Adults

Dieter Hoelzer and Nicola Gokbudget

Chapter 67 Myelodysplastic Syndrome: Biology and Treatment


Richard Stone and Daniel DeAngelo

Chapter 68 Polycythemia Vera

Ronald Hoffman, Kelty R. Baker and Joe Prchal

Chapter 69 Chronic Myeloid Leukemia

Charles Sawyers and Neil P. Shah

Chapter 70 Myelofibrosis with Myeloid Metaplasia

Ronald Hoffman and Farhad Ravandi-Kashani

Chapter 71 Essential Thrombocythemia

Steven Fruchtman and Ronald Hoffman

Chapter 72 Myelodysplastic Syndromes and Myeloproliferative Syndromes in Children

David M. Loeb, Robert P. Castleberry, and Cindy L. Schwartz

Chapter 73 Pathobiology of Non-Hodgkin Lymphomas

Gianluca Gaidano and Riccardo Dalla-Favera

Chapter 74 Patho-Biology of Hodgkin's Lymphoma

Stefano A. Pileri, Brunangelo Falini and Harold Stein

Chapter 75 Hodgkin's Disease: Clinical Manifestations, Staging, and Therapy

Volker Diehl, Daniel Re, and Andreas Josting

Chapter 76 The Pathologic Basis for the Classification of Non-Hodgkin Lymphomas

Elaine Jaffe and Stefania Piltaluga

Chapter 77 Clinical Manifestations, Staging, and Treatment of Non-Hodgkin Lymphoma

John G. Gribben and Ann S. La Casce

Chapter 78 Malignant Lymphomas in Childhood


John T. Sandlund, Jr.Michael P. Link

Chapter 79 Chronic Lymphocytic Leukemia

Dilip V. Patel and Kanti R. Rai

Chapter 80 Hairy Cell Leukemia

Annaadriana Zakanja, LoAnne C. Petersen, and Martin S. Tallman

Chapter 81 Cutaneous T-Cell Lymphomas

Timothy M. Kuzel, Joan Guitart, and Steven T. Rosen

Chapter 82 AIDS-Related Lymphomas

David T. Scadden

Chapter 83 Multiple Myeloma and Other Plasma Cell Disorders


Guido Tricot

Chapter 84 Immunoglobulin Light Chain Amyloidosis (Primary Amyloidosis, AL)

Morrie A. Gertz, Martha Q. Lacy, Angela Dispenzien

Chapter 85 Atypical Immune Lymphoproliferations

Timothy C. Greiner and Thomas G. Gross

Chapter 86 Clinical Approaches to Infections in the Compromised Host

Jo-Anne H. van Burik

Chapter 87 Nutritional Support of Patients with Hematologic Malignancies

Polly Lenssen and Saundra N. Aker

Chapter 88 Psychosocial Aspects of Hematologic Disorders

Ruth McCorkle, Siew Tzuh Tang, Jeannie Pasacreta

Chapter 89 Pain Management and Antiemetic Therapy in Hematologic Disorders

Janet L. Abrahm, Lauren Dias, and Bridget Fowler

Chapter 90 Palliative Care


Janet L. Abrahm and Barbara Sourkes

Chapter 91 Indwelling Access Devices

Janet L. Abrahm and Linda M. Pellerin

Chapter 92 Late Complications of Hematologic Diseases and Their Therapies

Wendy Landier and Smita Bhatia

Part VII. TRANSPLANTATION

Chapter 93 Hematopoietic Stem Cell Transplantation for Acquired Nonmalignant Diseases and

Myelodysplastic Syndrome

William Tse and H. Joachim Deeg

Chapter 94 Hematopoietic Cell Transplant for Immune Deficiences and Genetic Diseases

Stella M. Davies



Chapter 95 Results of Allogeneic Hematopoietic Cell Transplant for Hematologic

Malignancies

Andrea Bacigalupo

Chapter 96 Autologous Transplant for Hematologic malignancies and Solio Tumors

Stephen J. Forman and Jeffery R. Schriber

Chapter 97 Unrelated Donor Stem Cell Transplantation Therapy

Effie W. Petersdorf and Claudio Anasetti

Chapter 98 Umbilical Cord Blood Transplantation

Juliet N. Barker and John E. Wagner

Chapter 99 Preparative Regimens for Hematopoietic Cell Transplantation

Marcos de Lima and Sergio Giralt

Chapter 100 Graft-versus-Host Disease and Graft-versus-Leukemia

Pavan Reddy and James L.M. Ferrara

Chapter 101 Graft Engineering to Enhance Engraftment, Reduce Graft-versus-Host Disease and

Provide a Graft-versus-Tumor Effect

Catherine M. Bollard and Adrian P. Gee

Chapter 102 Gene Transfer for Hematologic Disorders

Katherine A. High and Malcolm K. Brenner

Chapter 103 Experimental Cell Therapy

Robert S. Negrin

Chapter 104 Complications After Hematopoietic Cell Transplantation

Daniel J. Weisdorf

Part VIII. HEMOSTASIS AND THROMBOSIS

Chapter 105 Megakaryocyte and Platelet Structure

Joseph E. Italiano and John Hartwig

Chapter 106 The Molecular Basis for Platelet Function

Edward F. Plow and Charles S. Abrams

Chapter 107 The Molecular Basis for Platelet Activation

Lawrence F. Brass

Chapter 108 The Blood Vessel Wall

Aly Karsan and John M. Harlan

Chapter 109 Molecular Basis of Blood Coagulation

Bruce Furie and Barbara C. Furie

Chapter 110 Molecular and Cellular Basis of Fibrinolysis

H. Roger Lijnen and Désiré Collen

Chapter 111 Regulatory Mechanisms in Hemostasis: Natural Anticoagulants

Charles T. Esmon

Chapter 112 Clinical Evaluation of Hemorrhagic Disorders: Bleeding History and Differential

Diagnosis of Pupura

Barry S. Coller and Paul I. Schniederman

Chapter 113 Laboratory Evaluation of Hemostatic Disorders

Jacob H. Rand and Lisa Senzel

Chapter 114 Structure, Biology, and Genetics of Factor VIII

Randal J. Kaufman and Stylianos E. Antonarakis

Chapter 115 Biochemistry of Factor IX and Molecular Biology of Hemophilia B

S. Jamie Freedman and Bruce Furie

Chapter 116 Clinical Aspects and Therapy of Hemophilia


Jay Nelson Lozier and Craig M. Kessler

Chapter 117 Inhibitors in Hemophilia

Donald I. Feinstein

Chapter 118 Other Clotting Factor Deficiencies

Harold R. Roberts and Miguel A. Escobar

Chapter 119 Disorders of Fibrinogen

José Martinez and Andres Ferber

Chapter 120 Structure, Biology, and Genetics of von Willebrand Factor

David Ginsburg and Denisa D. Wagner

Chapter 121 von Willebrand Disease: Clinical Aspects and Therapy

Gilbert C. White, II, and J. Evan Sadler

Chapter 122 Vitamin K: Metabolism and Disorders

Barbara C. Furie and Bruce Furie

Chapter 123 Inhibitors of Blood Coagulation

Donald I. Feinstein

Chapter 124 Disseminated Intrvascular Coagulation

Howard A. Liebman and Ilene C. Weitz

Chapter 125 Hemostatic Defects Associated with Dysproteinemias

Howard A. Liebman

Chapter 126 Disorders of Coagulation in the Neonate

Leonardo R. Brandao and Donna DiMichele

Chapter 127 Hypercoagulable States

Kenneth A. Bauer

Chapter 128 Venous Thromboembolism

Mark A. Crowther and Jeffrey S. Ginsberg

Chapter 129 Arterial Thromboembolism

Mark A. Crowther and Jeffrey S. Ginsberg

Chapter 130 Anticoagulation and Thrombolytic Therapy

Jeffrey I. Weitz

Chapter 131 Immune Thrombocytopenic Purpura, Neonatal Alloimmune


Thrombocytopenia, and Posttransfusion Purpura

James Bussel and Douglas Cines

Chapter 132 Thrombotic Thrombocytopenic Purpura and the Hemolytic Uremic Syndrome

Keith R. McCrae, J Evan Sadler, and Douglas Cines

Chapter 133 Thrombocytopenia Due to Platelet Destruction and Hypersplenism

Theodore E. Warkentin and John G. Kelton

Chapter 134 Hereditary Disorders of Platelet Function

Joel S. Bennett

Chapter 135 Acquired Disorders of Platelet Function

Jose Lopez and Perumal Thiagarajan

Part IX. TRANSFUSION MEDICINE

Chapter 136 Human Blood Group Anitgens and Antibodies

Part 1: Carbohydrate Determinants

Part 2: Protein Determinants

Marion E. Reid and Martin L. Olsson

Chapter 137 Human Platelet Antigens

Thomas J. Kunicki and Diane J. Nugent

Chapter 138 Human Leukocyte Antigen (HLA) and Human Neutrophil Antigen (HNA) Systems

Ena Wang, Francesco M. Marincola, and David Stroncek


Chapter 139 Principles of Red Blood Cell Transfusion

Paul M. Ness and Margot S. Kruskall

Chapter 140 Principles of Platelet Transfusion Therapy

Thomas S. Kickler

Chapter 141 Principles of Neutrophil (Granulocyte) Transfusions


Ronald G. Strauss

Chapter 142 Transfusion of Plasma Derivatives: Fresh-Frozen Plasma,


Cryoprecipitate, Albumin, and Immunoglobulins

Cassandra D. Josephson and Christopher D. Hillyer

Chapter 143 Preparation of Plasma-Derived and Recombinant Human Plasma Proteins


William N. Drohan and David B. Clark

Chapter 144 Transfusion Therapy for Coagulation factor Deficiencies

Catherine S. Manno and Peter Larson

Chapter 145 Hemapheresis and Cellular Therapy

Ellen F. Lazarus and Harvey G. Klein

Chapter 146 Practical Aspects of Stem Cell Collection

Scott D. Rowley, Stuart L. Goldberg, and Jack Hsu

Chapter 147 Transfusion Reactions


Edward L. Snyder and YanYun Wu

Chapter 148 Transfusion-Transmitted Diseases

Eberhard W. Fiebig, Michael P. Busch and Jay E. Menitove

Chapter 149 Transfusion Medicine in Hematopoietic Stem Cell and Solid Organ Transplantation

Richard M. Kaufman, Jerome Ritz and Walter H. Dzik

Chapter 150 Red Blood Cell Substitutes

Robert M. Winslow

Part X. CONSULTATIVE HEMATOLOGY

Chapter 151 Hematologic Manifestations of Systemic Disease: Liver and Renal Disease

Rachel Rosovsky and Peter W. Marks

Chapter 152 Hematologic Manifestations of Systemic Disease: Infection, Chronic Inflammation, and

Cancer


Peter W. Marks and David S. Rosenthal

Chapter 153 Hematologic Manifestations of AIDS

David H. Henry and James A. Hoxie

Chapter 154 Hematologic Problems in the Surgical Patient: Bleeding and Thrombosis

Mark T. Reding and Nigel S. Key

Chapter 155 Hematologic Aspects of Pregnancy

Edward J. Benz, Jr.

Chapter 156 Hematologic Manifestations of Childhood Illness

A. Kim Ritchey and Frank G. Keller

Part XI. SPECIAL TESTS AND PROCEDURES

Chapter 157 Bone Marrow Examination

Daniel H. Ryan and Harvey J. Cohen

Chapter 158 Automated Analysis of Blood Cells

Raymond E. Felgar and Daniel H. Ryan

Chapter 159 Laboratory Detection of Hemoglobinopathies and Thalassemias

Martin H. Steinberg and David Chui

Chapter 160 Antenatal Diagnosis of Hematologic Disorders

Kim Kramer and Harvey J. Cohen

Chapter 161 Use of Molecular Techniques in the Analysis of Hematologic Diseases

Michele Paessler and Adam Bagg

Chapter 162 Molecular Imaging in Hematology

Francis G. Blankenberg


Appendix Normal Blood Values: Selected Reference Values for Neonatal, Pediatric, and Adult

Populations

Sharon M. Geaghan

What People are Saying About This

From the Publisher

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Editorial Reviews

"Reflect[s] the state of the art. This is an excellent textbook that will appeal to a broad range of readers." - JAMA, review of previous edition

From the Publisher

5 Stars! from Doody

This third edition is a comprehensive compilation of both malignant and non-malignant hematology. The previous edition was published in 1995. The purpose, according to the editors, is to provide a resource for both beginners and experts eager to learn about the science and practice of hematology. They have achieved this laudatory goal rather well. The book is targeted for a broad audience including both clinical hematologists and bench scientists at all levels of training. The editors are all eminent authorities in their respective fields. This edition is particularly exhaustive in coverage of hematology with numerous new contributors and chapters being added. For example, the emerging area of stem cell transplantation is now extensively covered in depth. A unique feature of this textbook is the inclusion in most chapters of the contributors' preferred work-up and treatment of a clinical entity; this feature is particularly helpful to the non-expert. Also of benefit is the liberal use of charts and tables, which reinforce the main points of the text. The book could have benefited from color glossies, especially in the presentation of hematopathology slides. This third edition is a truly remarkable textbook with a thorough yet highly readable presentation of the hematology field. While the primary purpose is to provide a standard reference, it can very well be read from cover to cover. The quality of chapters is uniformly excellent with virtually all topics covered by experts in the field. This third edition compares favorably with other hematology references, including William's Hematology and Wintrobe's Clinical Hematology.

Ron Gartenhaus

This book is designed to be a comprehensive textbook for practitioners in the field of hematology. The purpose is to provide up-to-date clinical insights into the management of hematologic disorders. It is designed to provide clinicians with up-to-date knowledge about the rapid advances in molecular biology and immunology, especially as they relate to major clinical applications. Therefore, besides providing information that is state-of-the-art on the practice of hematology, this textbook succinctly and successfully bridges the interface between bench research and clinical practice. This book is aimed at individuals involved in the practice of hematology. It is written at a level that is understandable yet interesting to medical students, interns, residents, fellows, faculty, and private practitioners in the field of hematology. The book is well illustrated and contains numerous useful tables. The references are extensive and current. A nice feature of this book is the use of red highlighted boxes that emphasize clinically relevant information and clinical problems. This book is essential for individuals in the practice of hematology. It will be useful both as quick reference and as a complete authoritative source. The editors should be commended for coordinating the efforts of such a large group of outstanding contributors. Information is presented in a scholarly and clinically pertinent manner. It is difficult for any textbook to completely represent all areas of immunology; however, this textbook could have presented more information on the unique clinical and laboratory problems involved in bone marrow transplantation. Nevertheless, it is an excellent textbook without significantomissions.

Richard K. Burt

In less than a decade of existence, this textbook has swiftly established itself as an authoritative and reliable reference source in the hematology field. It appears to me that among the four major textbooks, Hematology: Basic Principles and Practice has achieved the most harmonious and balanced blend of basic science and clinical information. It is a welcome development of the past decade in the field of hematology.

Journal of the American Medical Association

This new edition of a text about the science and practice of hematology reflects the new directions and growth of the field as an academic and clinical discipline. It includes expanded information on stem cell transplantation as well as the personal strategies of many practitioners for the diagnosis and treatment of hematologic disorders. The 160 chapters discuss molecular, cellular, and immunologic bases; biology of stem cells and disorders of hematopoiesis; red blood cells, host defense and its disorders; malignancies; transplantation; hemostasis and thrombosis; transfusion medicine; consultative hematology; and special tests and procedures. Contains many b&w and color illustrations. The editors are professors of medicine associated with leading medical centers. Annotation c. Book News, Inc., Portland, OR (booknews.com)

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