Handbook of Copper Pharmacology and Toxicology / Edition 1

by Edward J. Massaro

Overview

Edward J. Massaro and a panel of leading biomedical researchers and clinical practitioners review, in-depth, the status of our current knowledge concerning the biochemistry of copper in general and its role in health and disease in particular. Drawing on the wealth of new information emerging from the molecular biology revolution, these experts survey the most important research areas of copper pharmacology and toxicology, including copper proteins and transport, copper toxicity and therapeutics, and copper metabolism and homeostasis. They also discuss the molecular pathogenesis of copper in a variety of metabolic diseases, Menkes and Wilson's diseases and occipital horn syndrome, as well as the role of copper in Parkinson's disease, prion disease, familial amytrophic lateral sclerosis (ALS), and Alzheimer's disease.

Product Details

ISBN-13:	9780896039438
Publisher:	Springer-Verlag New York, LLC
Publication date:	07/01/2002
Edition description:	2002
Pages:	608
Product dimensions:	7.01(w) x 10.00(h) x 0.06(d)

Table of Contents

I. Copper in Mammals.- 1 Biochemistry and Molecular Biology of Copper in Mammals.- II. Copper Proteins.- 2 Biochemistry of the Wilson’s Disease Protein.- 3 Biologically Relevant Properties of Copper-Containing Proteins Analyzed by Means of Semiquantitative and Quantitative Theoretical Descriptors.- 4 Molecular Modeling and Dynamics of Copper Proteins.- 5 The Prion Protein and Copper: What Is the Connection?.- 6 Prion Protein: A Synaptic Cuproprotein.- 7 Cyhrome-c Oxidase.- 8 The Fet3 Protein: A Multicopper Ferroxidase Essential to Iron Metabolism in Yeast.- 9 Interaction of Copper-Binding Proteins from Enterococcus hirae.- III. Copper Transport.- 10 Copper Uptake in Eukaryotic Cells.- 11 The Role of PINA in Copper Transport, Circadian Rhythms, and Wilson’s Disease.- 12 The Identification of Motifs Involved in the Intracellular Trafficking of the Menkes Disease Protein.- 13 Intracellular Copper Transport and ATP7B, the Wilson’s Disease Protein.- 14 A Multicopper Oxidase-Based Iron-Transport System in Yeast.- IV. Molecular Pathogenesis of Diseases of Copper Metabolism.- 15 Molecular Basis of Diseases of Copper Homeostasis.- 16 Disturbances of Copper Homeostasis and Brain Function.- 17 Role of Copper and Other Transition Metal Ions in the Pathogenesis of Parkinson’s Disease, Prion Diseases, Familial Amytrophic Lateral Sclerosis and Alzheimer’s Disease.- 18 Molecular Genetics and Clinical Aspects of Menkes Disease and Occipital Horn Syndrome.- 19 The Meaning of Alternative Transcripts of the Menkes Disease Gene.- 20 Expression Profiling in Menkes Disease.- 21 Regulation by Copper of the Expression of Human Bis, a New Gene Involved in the Cellular Stress Response to Metals.- 22 Non-Indian Childhood Cirrhosis: Using a Founder Population to Identify the UnderlyingGenetic Defect.- V. Copper Toxicity and Therapeutics.- 23 Biological Effects of Chronic Copper Exposure.- 24 Copper Toxicity to Tight Junctions in the Human Intestina Caco-2 Cell Line.- 25 Cellular Responses to Copper in Aquatic Organisms: Importance of Oxidative Stress and Alteration of Signal Transduction.- 26 Selective Removal of Copper Accumulating in the Form Bound to Metallothionein by Tetrathiomolybdate.- 27 Control of Copper in Wilson’s Disease and Diseases of Neovascularization, such as Cancer.- 28 Copper-Rich Metallothionein Polymers During the Development of Fulminant Hepatitis in LEC Rats: Effect of D-Penicillamine.- VI. Copper Metabolism and Homeostasis.- 29 Sensory Protein Modification: A New Feature in Copper Balancing.- 30 Comparative Analysis of Copper and Iron Metabolism in Photosynthetic Eukaryotes vs Yeast and Mammals.- 31 Copper and the Morphological Development of Streptomyces.- 32 Molecular Hardware of Copper Homeostasis in Enterococcus hirae.- 33 Copper Homeostasis in Plants.- 34 The Role of Copper Ions in Regulating Methane Monooxygenases in Methanotrophs.- 35 Regulatory Responses to Copper Ions in Fungi.

Editorial Reviews

Reviewer: Donald G. Barceloux, MD, FAACT, FACEP, FACMT (UCLA School of Medicine)
Description: This is a compilation of current research on copper by experts from North American, Europe, and Asia. The editor has assembled a variety of international experts on various aspects of copper proteins, transport, metabolism, homeostasis, and toxicity. The book's 35 chapters are divided into sections on copper biochemistry and molecular biology, copper proteins, copper transport, molecular pathogenesis of diseases associated with copper metabolism, copper toxicity and therapeutics, and copper metabolism and homeostasis.
Purpose: As the editor states in his preface, the purpose is to provide researchers and students with the current status of research in selected areas of copper pharmacology and toxicology. In this sense the book provides a number of interesting discussions on a variety of little-known topics ranging from the association of prion protein ("mad cow disease") with copper to the role of copper in the pathogenesis of Parkinson's and Alzheimer's diseases.
Audience: The intended audience is the research-oriented reader with a special interest in the latest data on the molecular basis of copper homeostasis in both the normal and disease states. The book provides a detailed update of the latest genetic information on copper metabolism and transport including the genetic defects associated with Menkes disease (i.e., transmembrane copper-transporting P-type ATPase called ATP7A) and Wilson's disease (i.e., copper-transporting P-type ATPase called ATP7B). Although directed primarily at those doing level, some clinicians with a special interest in copper-associated diseases will find a wealth of background information on copper mechanisms as well as detailed discussions of the pathophysiology of Menkes disease, Wilson's disease, Indian childhood cirrhosis, and idiopathic copper toxicosis.
Features: Each chapter is well referenced with many chapters containing over 100-200 references. The formatting allows the reader to peruse the individual chapters easily for topics of interest. The book is well-illustrated with a variety of well-designed figures including some 3-dimensional color structures. The book contains little data on the toxicity of copper in humans — the information provided primarily involves the development of lowest observable adverse effect level (LOAEL). References to the acute and chronic effects of copper in humans are primarily secondary references or references to hypersensitive populations rather than to acute and chronic copper toxicity in normal populations.
Assessment: The editor achieves his goal of providing an update on the latest research on copper metabolism and homeostasis. The book contains a number of interesting topics ranging from characterization of copper transport at the molecular level (e.g., chaperones, Menkes and Wilson proteins) to discussions about the potential role of copper in certain neurological diseases. The organization and style of the book allow the reader to find material of interest quickly. Although the book is primarily of interest to the reader involved in copper research, some clinicians with a special interest in diseases associated with copper will find a great deal of detailed information on copper kinetics and pathophysiology.

Doody's Review Service

3 Stars from Doody

"...biochemical and molecular researchers from around the globe have produced 35 chapters documenting the present state of knowledge in selected areas of copper pharmacology and toxicology. the state-of-the-art data provided will no doubt stimulate challenging research with this essential trace element required by organism ranging from bacteria to mammals." - Veterinary and Human Toxicology

"The book has excellent introductory chapters, and summarizes much recent research at the genetic and cellular levels." - Newsletter of the British Toxicological Society

"Dr. Massaro must be congratulated for editing this comprehensive book on copper. There are so many outstanding chapters in this compendium that highlighting any one of them should not detract from the others...this book is a treasure trove of references. The price of the book, though modest for this compendium would be justified for the Preface and the first chapter alone. This book is highly recommended. At the present time it has no equal." -International Journal of Toxicology

From the Publisher