Genome Editing in Neurosciences

by Rudolf Jaenisch, Feng Zhang, Fred Gage

Overview

This book is open access under a CC BY 4.0 license.

CRISPR-Cas9 is a rapid, efficient, versatile and relatively cheap method for dissecting the molecular pathways that are the basis of life, as well as for investigating and potentially rectifying faults in these pathways that result in disease.

This book reviews how CRISPR-Cas9 and other genome editing techniques are advancing our understanding of development and function in the nervous system, uncovering the molecular causes of neurological disorders and providing tools for gene therapy.

Product Details

ISBN-13:	9783319601915
Publisher:	Springer International Publishing
Publication date:	09/15/2017
Series:	Research and Perspectives in Neurosciences
Edition description:	1st ed. 2017
Pages:	123
Product dimensions:	6.30(w) x 9.30(h) x 0.30(d)

About the Author

Rudolf Jaenisch, MIT Cambridge, USA
Feng Zhang, MIT Cambridge, USA
Fred Gage, Salk Institute for Biological Studies, La Jolla, CA, USA

Table of Contents

Introduction.- In vitro modeling of complex neurological diseases.- Aquatic model organisms in neurosciences : the genome editing revolution.- Genome-wide genetic screening in the mammalian CNS.- CRISPR/Cas9-mediated Knockin and Knockout in Zebrafish.- Dissecting the role of synaptic proteins with CRISPR.- Recurrently Breaking Genes in Neural Progenitors: Potential Roles of DNA Breaks in Neuronal Function, Degeneration and Cancer.- Neuroscience research using non-human primate models and genome editing.- Multiscale genome engineering: Genome-wide screens and targeted approaches.- Using Genome Engineering to Understand Huntington’s Disease.- Therapeutic gene editing in muscles and muscle stem cells.