Gap Junction Channels and Hemichannels / Edition 1

Gap Junction Channels and Hemichannels / Edition 1

ISBN-10:
1498738621
ISBN-13:
9781498738620
Pub. Date:
08/18/2016
Publisher:
Taylor & Francis
ISBN-10:
1498738621
ISBN-13:
9781498738620
Pub. Date:
08/18/2016
Publisher:
Taylor & Francis
Gap Junction Channels and Hemichannels / Edition 1

Gap Junction Channels and Hemichannels / Edition 1

$240.0
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Overview

Gap junction channels are a group of intercellular channels expressed in tissues and organs to synchronize many physiological processes. A gap junction channel is formed by the docking of two hemichannels, and each hemichannel is a hexamer of connexins. The field of gap junction channel and hemichannel research has recently exploded and became one of the most active areas of cell biology. Numerous novel approaches and techniques have been developed, but there is no single book dedicated to the unique techniques and protocols employed for the research on these large pore channels. This book fills the gap and focuses on protocols, approaches and reviews of gap junction channels and connexin hemichannels. It will be a useful reference for graduate students, postdoctoral fellows and researchers. Anyone with an interest in gap junction channels and hemichannels will need this summary of state-of-the-art techniques and protocols.


Product Details

ISBN-13: 9781498738620
Publisher: Taylor & Francis
Publication date: 08/18/2016
Series: Methods in Signal Transduction Series , #14
Pages: 305
Product dimensions: 6.12(w) x 9.19(h) x (d)

About the Author

Donglin Bai received his Ph.D. from University of Cambridge, U.K. (1994). He then moved to Canada and worked on neurotransmitter receptors (GABA, NMDA, AMPA, noradrenaline, angiotensin) in Loeb Research Institute (Ottawa), Department of Physiology (Toronto) and Samuel Lunenfeld Research Institute (Toronto) as a postdoctoral fellow. In 2002 he was recruited as an Assistant Professor at Department of Physiology and Pharmacology, the University of Western Ontario. He is currently a tenured Associate Professor in the same university. His current research interests are on the physiology of gap junction channels, including gap junction channel docking, single channel conductance and gating properties. He is also interested in revealing how gap junction gene mutants linking to human diseases (cardiac arrhythmias, hypomyelination, cataracts, deafness and skin diseases) and developing strategies of rescuing the mutants. He received grants support from the following Canadian funding agencies: CIHR, CRC, NSERC, HSFC and ERA.

Table of Contents

Gap junction channels. Bioinformatics analysis of connexin genes. Structural approaches on gap junction channels. Fluorescent label of connexins. Functional study of gap junction channel gating. Quantitative measurement of dye transfer. Permeability. Pharmacology of gap junction channels. Gap junction mimetic piptides. Gap junction hemichannels. Dye uptake and ATP release. Functional study of hemichannel current. Connexin purification and reconstitution in lipid bilayers. Hemichannel function in the ovary. Pannexin channels. Functional study pannexin channels. Pannexin channels in vasculature. Pharmacology of pannexin channels. Dye uptake and ATP release.

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