Fluorine-containing Amino Acids: Synthesis and Properties / Edition 1

by Valery P. Kukhar, Vadim A. Soloshonok

Overview

In recent years, organo-fluorine chemistry has made a marked impacton the design and synthesis of a large variety of biologicallyactive molecules, such as steroids, carbohydrates, amines, aminoacids, peptides and other natural products. Naturally occurringamino acids play a pivotal role in living systems, and thereforesynthetic fluorine-containing amino acids have been of significantinterest to researchers working towards the understanding andmodification of physiological processes. Fluorine-containing AminoAcids:
* is the first volume devoted to the synthesis and properties offluorine-containing amino acids
* pays special attention to the preparation of enantiomericallypure acids (which are essential to the modern pharmaceuticalindustry)
* deals with a rapidly expanding field of research
* has been written by experienced researchers who are responsiblefor many developments in the field
* highlights the interdisciplinary nature of this topic
Fluorine-containing Amino Acids is the only dedicated reference inthis subject and will be essential for researchers in syntheticorganic, peptide, natural product, and medicinal chemistry andbiochemistry.

Product Details

ISBN-13:	9780471952039
Publisher:	Wiley
Publication date:	04/06/1995
Pages:	424
Product dimensions:	6.22(w) x 9.27(h) x 1.18(d)

About the Author

Valery P. Kukhar is the editor of Fluorine-containing Amino Acids: Synthesis and Properties, published by Wiley. Vadim A. Soloshonok is the editor of Fluorine-containing Amino Acids: Synthesis and Properties, published by Wiley.

Table of Contents

Partial table of contents:

Syntheses of Fluorine-Containing Amino Acids by Methods ofClassical Amino Acid Chemistry (V. Tolman).

Preparation of Fluorine-Containing Amino Acids by Methods ofOrganofluorine Chemistry (V. Kukhar).

Synthesis of Fluorine-Containing Amino Acids by Means ofHomogeneous Catalysis (I. Ojima & Q. Dong).

Synthesis of beta-Fluorine-Containing Amino Acids (N. Sewald &K. Burger).

Asymmetric Synthesis of Fluorine-Containing Amino Acids (V. Kukhar,et.

al).

Enzymatic Synthesis of Fluorine-Containing Amino Acids (Y.Matsumura & M. Urushihara).

Enzymatic Resolution of Racemic Fluorine-Containing Amino Acids (T.Miyazawa).

High-Performance Liquid Chromatography of Fluorine-Containing AminoAcids (S. Galushko).

Renin Inhibitors with Fluorine-Containing Amino Acid Derivatives(H. Sham).

Index.

Editorial Reviews

A comprehensive reference devoted to the synthesis and biological properties of fluorine-containing amino acids (FAAs). Special attention is paid to the preparation of enantiomerically pure acids (which are essential to the modern pharmaceutical industry). Among the topics: syntheses of fluorine-containing amino acids by methods of classical amino acid chemistry; asymmetric synthesis of FAAs; enzymatic synthesis of FAAs; high-performance liquid chromatography of FAAs; and synthesis and biochemical applications of fluorine- containing peptides and proteins. Annotation c. Book News, Inc., Portland, OR (booknews.com)

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