Cytokines in the Genesis and Treatment of Cancer / Edition 1

by Michael A. Caligiuri, Michael T. Lotze

Overview

Cytokines in the Genesis and Treatment of Cancer provides a comprehensive picture of the dual role of host responses in promoting and inhibiting tumor progression. This volume represents an important investigation into the emerging intersection of cancer biology and cancer immunology. Divided into four sections, the volume’s first three parts focus on cytokines in the genesis of cancer. The final section describes the notable progress — both in animal models and humans — in demonstrating the use of cytokine or anticytokine therapies for the prevention and treatment of cancer. Cytokines in the Genesis and Treatment of Cancer brings together an impressive array of internationally distinguished investigators who are devoted to the study of cytokines and cancer. Together, they produce an insightful, comprehensive discussion of cytokines and cancer that will serve as the perfect reference for all those working in the field.

Product Details

ISBN-13:	9780896038202
Publisher:	Springer-Verlag New York, LLC
Publication date:	04/20/2007
Series:	Cancer Drug Discovery and Development
Edition description:	2007
Pages:	482
Product dimensions:	7.01(w) x 10.00(h) x 0.05(d)

Table of Contents

Infectious Agents, Cytokines, and Cancer.- Helicobacter pylori and Cytokines in the Genesis of Gastric Cancer.- HTLV-1, Cytokines,and Cancer.- Herpesviruses, Cytokines, and Cancer.- Cytokines and Carcinogenesis.- Tumor Necrosis Factor and Cancer.- Transforming Growth Factor-β and Cancer.- Interleukin-1 Family of Cytokines and Cancer.- Interleukin-4/13 and Cancer.- Interleukin-6 and Castleman’s Disease.- Interleukin-10 (IL-10).- Cytokines in Multiple Myeloma.- In Vivo Murine Cytokine Models and the Genesis of Cancer.- Experimental Models of Cytokines and Cancer Prevention.- Cytokines and Tumor Stroma/Metastasis.- Cytokines in the Tumor Stroma.- Cytokines and Tumor Angiogenesis.- Chemokine and Receptor Expression in Tumor Progression.- The Biology of Cancer Cachexia and the Role of TNF-α.- Cytokines in the Treatment of Cancer.- Interleukin-2 and Cancer Therapy.- Interleukin-12 and Cancer Therapy.- The Type I Interferon System With Emphasis on Its Role in Malignancies.- Combination Cytokine Therapy.- Novel Strategies for Cytokine Administration Via Targetting.- Cytokines and Cancer Vaccines.- Anticytokine Treatment.- Cytokines in the Supportive Care of Cancer.

Editorial Reviews

From the reviews:

"...brings together an impressive array of internationally distinguished investigators who are devoted to the study of cytokines and cancer. Together,, they produce an insightful, comprehensive discussion of cytokines and cancer that will serve as the perfect reference for all those working in the field." -Anticancer Research

"This is a collection of papers from a large number of authors on the role of cytokines in the genesis of neoplastic diseases including metastatic spreads and the potential role in therapy. … Chronic cytokine production can contribute to the generation and progression of cancer. Mechanisms involved in this process are described in the many chapters of this volume. The book is highly recommended to all of those involved in the study of neoplastic diseases." (Julian L. Ambrus, The Journal of Medicine, March, 2008)

“This new volume in Humana’s series will be necessary reading for researchers, oncologists, pharmacologists, radiotherapists.” (Tumori, Vol. 93, 2007)

From the Publisher