Cortical Plasticity / Edition 1

by Sam Fazeli, Graham L. Collingridge

Overview

Understanding the mechanisms of learning and memory provides one of the major challenges of contemporary neuroscience. At the reductionist level this equates to an understanding of synaptic plasticity within cortical structures such as the hippocampus. Recently, considerable effort has been devoted to researching two forms of associative synaptic plasticity: long-term potentiation (LTP) and its counterpart, long-term depression (LTD). Increasingly, this field is being influenced by molecular approaches, and Cortical Plasticity brings together the recent findings on all aspects of the induction, maintenance, and expression of LTP and LTD, with an emphasis on molecular mechanisms. This book provides an invaluable overview of a rapidly expanding field and presents discussions from internationally known researchers on a number of controversial issues regarding synaptic plasticity. It will be essential reading for researchers in all areas of neuroscience.

Product Details

ISBN-13:	9781872748740
Publisher:	Taylor & Francis
Publication date:	06/15/1996
Series:	Molecular and Cellular Neurobiology Series
Pages:	268
Product dimensions:	6.12(w) x 9.19(h) x (d)

About the Author

Sam Fazeli (Author), Graham L. Collingridge (Author)

Table of Contents

1. Introduction and overview 2. The role of amino acid receptors in synaptic plasticity 3. Second messengers in LTP and LTD 4. The locus of expression of NMDA receptor-dependent LTP in the hippocampus 5. Post-translational mechanisms which could underlie the postsynaptic expression of LTP and LTD 6. Postsynaptic gene expression and long-term potentiation in the hippocampus 7. Neuromodulators of synaptic strength 8. Epileptogenesis 9. Bidirectional plasticity of cortical synapses 10. Synaptic plasticity in the cerebellum 11. Roles of LTP and LTD in neuronal network operations in the brain