Computational Systems Biology: From Molecular Mechanisms to Disease / Edition 2

by Andres Kriete, Roland Eils

Overview

This comprehensively revised second edition of Computational Systems Biology discusses the experimental and theoretical foundations of the function of biological systems at the molecular, cellular or organismal level over temporal and spatial scales, as systems biology advances to provide clinical solutions to complex medical problems. In particular the work focuses on the engineering of biological systems and network modeling.

Product Details

ISBN-13:	9780124059269
Publisher:	Elsevier Science
Publication date:	12/12/2013
Edition description:	2nd Revised ed.
Pages:	548
Product dimensions:	7.50(w) x 9.25(h) x (d)

About the Author

Associate Professor for Bioinformation Engineering at Drexel University, Philadelphia and Director of the Biocomputing Laboratory at the Coriell Institute for Medical Research

Professor of Bioinformatics at the University of Heidelberg and Director of the Division of Theoretical Bioinformatics at the German Cancer Research Center (DKFZ) in Heidelberg

Table of Contents

Introducing Computational Systems Biology; Protein Interactions, Stability and Regulation; Transcriptional control; Introduction to Computational Models of Biochemical Reaction Networks; Biological Foundations of Signal Transduction and Aberrations in Disease; A discrete approach to top-down modeling of biochemical networks; Reconstruction of metabolic network from genome information and its structural and functional analysis; Gene networks: estimation, modeling and simulation; Standards, platforms and tools; Computational models for circadian rhythms: Deterministic versus stochastic approaches; Integrated imaging informatics; Imaging and Modeling of complex tumor formation; Imaging to help decipher an model higher orders of complexity; Multistability and multicellularity: cell fates as high-dimensional attractors of gene regulatory networks; Whole Cell Modeling; Databases for Systems Biology; Systems Biology of the Microbiome; Systems Immunology; Applying systems biology to understand the immune response to infection and vaccination; Aging and Systems Biology; From Cardiac Mitochondria to Systems Physiology; Cancer Systems Biology; Systems Medicine, Drug Biology and Interventions; Towards a blueprint of an entire organism

What People are Saying About This

From the Publisher

This comprehensively revised new edition reviews fundamentals and recent breakthroughs in computational simulation and multi-scale analysis techniques across biological systems, with new chapters covering complex systems and emerging phenotypes.

Editorial Reviews

"…revised and updated to include the latest advances in cancer, aging, and development modeling research. The first chapter introduces the field and reviews the content to follow, while the ensuing six chapters lay the foundations of modeling networks, systems analysis, biochemistry, and signal transduction underlying the systems approach,…" —ProtoView.com, April 2014

From the Publisher