Clinical Bioinformatics / Edition 1

by Ronald J.A. Trent

Overview

With the ever-increasing volume of information in clinical medicine, researchers and health professionals need computer-based storage, processing and dissemination. In Clinical Bioinformatics, leading experts in the field provide a series of articles focusing on software applications used to translate information into outcomes of clinical relevance. Covering such topics as gene discovery, gene function (microarrays), DNA mutation analysis, proteomics, online approaches and resources, and informatics in clinical practice, this volume concisely yet thoroughly explores its cutting edge subject.

In this emerging "omics" era, Clinical Bioinformatics is the perfect guide for researchers and clinical scientists to unlock the complex, dense, and ever-growing accumulation of medical information.

Product Details

ISBN-13:	9781588297914
Publisher:	Springer-Verlag New York, LLC
Publication date:	12/18/2007
Series:	Methods in Molecular Medicine , #141
Edition description:	2008
Pages:	382
Product dimensions:	5.98(w) x 9.02(h) x 0.04(d)

Table of Contents

In Silico Gene Discovery.- Whole Genome-Wide Association Study Using Affymetrix SNP Chip: A Two-Stage Sequential Selection Method to Identify Genes That Increase the Risk of Developing Complex Diseases.- Utilizing HapMap and Tagging SNPs.- Measuring the Effects of Genes and Environment on Complex Traits.- Microarrays—Planning Your Experiment.- Clinical Uses of Microarrays in Cancer Research.- Microarrays—Analysis of Signaling Pathways.- Microarrays—Identifying Molecular Portraits for Prostate Tumors with Different Gleason Patterns.- Microarrays for the Study of Viral Gene Expression During Human Cytomegalovirus Latent Infection.- Computer-Assisted Reading of DNA Sequences.- Evaluating DNA Sequence Variants of Unknown Biological Significance.- Developing a DNA Variant Database.- Protein Comparative Sequence Analysis and Computer Modeling.- Identification and Characterization of Microbial Proteins Using Peptide Mass Fingerprinting Strategies.- Statistical Analysis of Image Data Provided by Two-Dimensional Gel Electrophoresis for Discovery Proteomics.- Online Resources for the Molecular Contextualization of Disease.- Web-Based Resources for Clinical Bioinformatics.- Developing Decision Support Systems in Clinical Bioinformatics.- eConsulting.