Clinical Applications of Magnetic Nanoparticles: From Fabrication to Clinical Applications / Edition 1

by Nguyen TK Thanh

Overview

Offering the latest information in magnetic nanoparticle (MNP) research, this book builds upon the success of the first volume and provides an updated and comprehensive review, from synthesis, characterization, and biofunctionalization to clinical applications of MNPs, including the diagnosis and treatment of cancers. The book captures some of emerging research area which was not available in the first volume. Good Manufacturing Practices and Commercialization of MNPs are also included. This volume, also written by some of the most qualified experts in the field, incorporates new developments in the literature, and continues to bridge the gaps between the different areas in this field.

Product Details

ISBN-13:	9781138051553
Publisher:	Taylor & Francis
Publication date:	02/27/2018
Pages:	516
Product dimensions:	8.25(w) x 11.00(h) x (d)

About the Author

Professor Nguyen TK Thanh, FRSC, MInstP (http://www.ntk-thanh.co.uk) held a prestigious Royal Society University Research Fellowship (2005-2014). She was appointed a Full Professor in Nanomaterials in 2013 at Biophysics Group, Department of Physics and Astronomy, University College London, UK. She leads a very dynamic group conducting cutting edge interdisciplinary and innovative research on the design, and synthesis of magnetic and plasmonic nanomaterials for biomedical applications. A very strong feature of her research program is the development of new chemical methods and in collaboration with chemical engineers to produce the next generation of nanoparticles with very high magnetic moment, and novel hybrid and multifunctional nanostructures. Detailed mechanistic studies of their formation by sophisticated and advanced analysis of the nanostructure allows tuning of the physical properties at the nanoscale; these can subsequently be exploited for diagnosis and treatment of various diseases. The studies are conducted to provide insight for future material design approaches. It will also help to identify the critical process parameters that can be manipulated in order to obtain the suitable physical properties for the intended applications.

She was the sole editor of the book: "MAGNETIC NANOPARTICLES: FROM FABRICATION TO CLINICAL APPLICATIONS" published by CRC Press/Taylor and Francis: http://www.crcpress.com/product/isbn/9781439869321. In 2016, she was a Guest Editor of The Royal Society Interface Focus on "Multifunctional nanostructures for diagnosis and therapy of diseases".

She has published over 80 peer reviewed journal articles and book chapters with over 4000 citations so far. She has been Visiting Professors at various Universities in France, Japan, China and Singapore. She has been an invited speaker at nearly 200 institutes and scientific meetings. She has a leadership role in professional communities by chairing and organising 30 high profile international conferences such as American Chemistry Society symposia in 2018, 2012, 2010; Royal Society of Chemistry UK Colloids Conferences in 2017, 2014, 2011; European Material Research Society Symposia in 2016, 2013; ICMAT Singapore in 2015, 2013; Faraday Discussions in 2014 and being a member of advisory boards in Europe, USA and Japan. She served in Joint Committee of the Royal Society of Chemistry Colloid & Interface Science Group and the Society of Chemical Industry Colloid & Surface Chemistry Group (2008-2017). She is an elected member of The Royal Society of Chemistry Faraday Division Council and currently serving in Awards Committee and was a representative member of Joint Colloids Groups (2013-2016). She is a workgroup leader of EU COST Action TD1402 on Multifunctional Nanoparticles for Magnetic Hyperthermia and Indirect Radiation Therapy (RADIOMAG). She is a Co-chair of the 13^th International Conference on the Scientific and Clinical Applications of Magnetic Carriers in June 2020, London, UK.

Table of Contents

Fabrication and Characterisation of MNPs

Controlling the size and the shape of uniform magnetic iron oxide nanoparticles for biomedical applications

Magnetic Nanochains: properties, synthesis and prospects

Magnetisation dynamics for magnetic particle detection at the nano-scale

Biofunctionalisation of MNPs for Biomedical Application

Challenge of functionalisation of MNPs

Iron oxide nanoparticles embedded in polymer vesicles as contrast agent for MRI

Encapsulation of drugs in functionalized nanoparticles MNPs

Ex-vivo Application of MNPs

Working Principles of Magnetic Separation for Biomedical Diagnostic Applications

Magnetic separation in integrated micro analytical systems

Magnetic-Plasmonic Hybrid Nanoparticles for Organelle Separation

Magnetic nanoparticles based biosensing. Metallic nanoparticles (carbon coated)

In-vivo Application of MNPs

Immunotoxicity and safety considerations for iron oxide nanoparticles

Impact of core and functionalized magnetic nanoparticles on human health

Mechanisms of macrophage recognition of iron oxide nanoparticles

Bioheat modeling

Designing Magnetic Nanoparticles for Cancer Treatment using Magnetic Hyperthermia

Nanoparticles for nanorobotic agents dedicated to cancer therapy

Smart nanoparticles an the effects in magnetic hyperthermia in vivo

Non-invasive guidance scheme of magnetic nanoparticles for drug targeting in Alzheimer’s disease

Development of magnetic porous PDMS for on-demand drug delivery applications

Ferrofluid for hyperthermia and targeted and sustained drug delivery

Magnetic Particle Transport through Complex Media

Magnetic nanoparticles for neural engineering

MRI

Multimodal imaging of magnetic nanoparticles: applications and methodologies

Red Blood Cell constructs to prolong in vivo the life span of iron-based MRI/MPI contrasting agents

Animal Studies of Magnetic Nanoparticles

Bio-inspired magnetic nanoparticles for biomedical applications

Microwheel for blood clot

Stimuli regulated Cancer Theranostics Based on Magnetic Nanoparticles

Regulatory and Commercialisation

Good Manufacturing Practices (GMP) of Magnetic nanoparticles

Commericalisation of new variety of magnetic particles to the global market