Cell Therapy, Stem Cells and Brain Repair / Edition 1

by Cyndy D. Davis, Paul R. Sanberg

Overview

As our world continues to evolve, the field of regenerative medicine f- lows suit. Although many modern day therapies focus on synthetic and na- ral medicinal treatments for brain repair, many of these treatments and prescriptions lack adequate results or only have the ability to slow the p- gression of neurological disease or injury. Cell therapy, however, remains the most compelling treatment for neurodegenerative diseases, disorders, and injuries, including Parkinson’s disease, Huntington’s disease, traumatic brain injury, and stroke, which is expanded upon in more detail in Chapter 1 by Snyder and colleagues. Cell therapy is also unique in that it is the only therapeutic strategy that strives to replace lost, damaged, or dysfunctional cells with healthy ones. This repair and replacement may be due to an administration of exogenous cells itself or the activation of the body’s own endogenous reparative cells by a trophic, immune, or inflammatory response to cell transplantation. However, the precise mechanism of how cell therapy works remains elusive and is c- tinuing to be investigated in terms of molecular and cellular responses, in particular. Moreover, Chapter 11 by Emerich and associates, discusses some of the possibilities of cell immunoisolation and the potential for treating central nervous system diseases.

Product Details

ISBN-13:	9781588295026
Publisher:	Springer-Verlag New York, LLC
Publication date:	09/01/2006
Series:	Contemporary Neuroscience
Edition description:	2007
Pages:	392
Product dimensions:	5.98(w) x 9.02(h) x 0.04(d)

Table of Contents

Current Views of the Embryonic and Neural Stem Cell.- Developing Novel Cell Sources for Transplantation in Parkinson’s Disease.- Neural Transplantation in the Nonhuman Primate Model of Parkinson’s Disease.- Cell-Based Therapy for Huntington’s Disease.- Use of Bone Marrow Stem Cells as Therapy for Behavioral Deficits in Rodent Models of Huntington’s Disease.- Human Neuroteraarcinoma Cells as a Neural Progenitor Graft Source for Cell Transplantation in Stroke.- Therapeutic Applications of Bone Marrow-Derived Stem Cells in Neurologic Injury and Disease.- Cell Therapy for Models of Pain and Traumatic Brain Injury.- The Use of Sertoli Cells in Neural Transplantation.- The Choroid Plexus.- Progress and Challenges in Immunoisolation for CNS Cell Therapy.- Evidence-Based Methodology for Advancing Neural Reconstruction.- Hematopoietic Cell Therapy for Brain Repair.- Stem Cells and Regenerative Medicine.

Editorial Reviews

Reviewer: Celso Agner, MD, MS, MSc (Michigan Neurology Partners)
Description: Stem cell research has become a hot topic due to the possibilities for treatment of neurodegenerative conditions such as Alzheimer's dementia, Parkinson's disease, and others affecting cognition, movement, or both. Therefore, a broad review on the topic is essential for current medical practice.
Purpose: This book starts with the very simple idea of incorporating old concepts into the new milestones of stem cell research.
Audience: Neurologists, neurosurgeons, and scientists are the main target audience. Despite the complexity of the topic, the book is appropriate for everyone's level of expertise.
Features: The 41 authors contribute 14 chapters. In each chapter, there is a reflection on the history of cell transplantation, where we came from and where we are going. I found the most interesting area to be the application of multiple cell progenitor varieties for different neurodegenerative diseases, such as stroke and Huntington's disease. The application of the new technologies would likely improve the overall outcome in these conditions.
Assessment: This excellent book reflects the recent advances in stem cell/tissue transplantation research. This is a must buy in any large research-oriented university.

Doody's Review Service

Reviewer: Celso Agner, MD, MS, MSc(University of Illinois at Chicago College of Medicine)
Description: Stem cell research has become a hot topic due to the possibilities for treatment of neurodegenerative conditions such as Alzheimer's dementia, Parkinson's disease, and others affecting cognition, movement, or both. Therefore, a broad review on the topic is essential for current medical practice.
Purpose: This book starts with the very simple idea of incorporating old concepts into the new milestones of stem cell research.
Audience: Neurologists, neurosurgeons, and scientists are the main target audience. Despite the complexity of the topic, the book is appropriate for everyone's level of expertise.
Features: The 41 authors contribute 14 chapters. In each chapter, there is a reflection on the history of cell transplantation, where we came from and where we are going. I found the most interesting area to be the application of multiple cell progenitor varieties for different neurodegenerative diseases, such as stroke and Huntington's disease. The application of the new technologies would likely improve the overall outcome in these conditions.
Assessment: This excellent book reflects the recent advances in stem cell/tissue transplantation research. This is a must buy in any large research-oriented university.

"...covers the wide field of cell therapy and evaluates potential future treatments for neurodegenerative diseases and brain injuries...suitable for scientists and clinicians to gain a comprehensive overview on modern stem-cell research in regenerative medicine." -Schwfizer Archiv fur Neruologie und Psychiatrie

From the Publisher