Blood Substitutes: New Challenges / Edition 1

by Robert M. Winslow, Kim D. Vandegriff, Marcos Intaglietta

Overview

This book is not a "proceedings" volume. Rather the chapters are essays by experts in the field of blood substitutes, invited by the editors to con­ tribute to the 1996 "Current Issues in Blood Substitutes Research and Development" course given in San Diego, March 18-21. The contributors were selected because of their expertise in areas deemed by the editors to be critical to the advancement of the field. The course, as in past years, is heavily influenced by feedback from par­ ticipants, and by research in this and related fields. In addition to the didactic lectures (for which these chapters are the foundation), the course also offers the opportunity for presentation of research reports, progress reports from the various companies currently commercializing products, and round table discussions of selected subjects. Thus, we are grateful to past participants for their helpful comments. Production of a book, especially on a short timeline, is not an easy feat.

Product Details

ISBN-13:	9780817638788
Publisher:	Birkhäuser Boston
Publication date:	03/28/1996
Series:	[Advances in Blood Substitutes Series , #2
Edition description:	1996
Pages:	210
Product dimensions:	6.10(w) x 9.25(h) x 0.02(d)

About the Author

Winslow, Robert M., MD (UCSD); Vandegriff, Kim D., PhD (UCSD); Intaglietta, Marcos, PhD (UCSD)

The contributors represent the specialties of hematology, surgical research, blood transfusion, laboratory medicine, microbiology, biomedical research, bioengineering, anesthesiology, and medicine. Most are from U.S. academic medical centers and research institutions. Twelve are from the U.K., Europe, Japan, and China. Institutions prominently represented include UCSD, Rice Univ, and Red Cross Blood Transfusion Service in Amsterdam.

Table of Contents

1 Blood Substitutes: 1995 in the Literature.- 2 Blood Substitutes: What is the Target?.- 3 Blood Flow Distribution During Shock.- 4 Blood Substitute Oxygen Carriers Designed for Clinical Applications.- 5 Interaction of Hemoglobin with Nitric Oxide and Carbon Monoxide: Physiological Implications.- 6 Biological Consequences of Cross-linked Hemoglobin in Animal Models of Surgery and Endotoxemia.- 7 Hemorrhagic Disorders After Administration of Glutaraldehyde-polymerized Hemoglobin.- 8 Microvascular Oxygen Distribution: Effects Due to Free Hemoglobin in Plasma.- 9 Experimental Simulation of Oxygen Transport in Microvessels.- 10 Carbon Dioxide Transport by Hemoglobin-Based Blood Substitutes.- 11 Non-phospholipid Liposomes: A Novel Method for the Preparation of Hemoglobin Containing Lipid Vesicles.- 12 Hemoglobin-Endotoxin Interactions.

Editorial Reviews

Reviewer: David James Dries, MSE, MD (Regions Hospital)
Description: This is a first edition of a hardbound collection of essays on topics related to the development of blood substitutes.
Purpose: Compiled are a series of chapters providing the foundation for didactic lectures on clinical and basic science issues related to blood substitute development. The format begins with fundamental concepts and epidemiology and proceeds to specific discussion of contemporary problems in this field.
Audience: Clinicians and basic scientists with an interest in the clinical problem of resuscitation from various shock states are an appropriate audience for this work. The authors represent an international group of authorities; many are from University of California at San Diego.
Features: Twelve chapters make up this compact, attractive hardbound text. The presentations begin with an overview of recent literature (1995) describing developments in the field of blood substitutes followed by a description of the blood usage problem, the physiology of shock, and derangement of oxygen transport in this state. Next, the authors develop various issues surrounding biological effects of blood substitutes including interaction of hemoglobin with endotoxin and oxygen transport in the microcirculation. Recent understanding of the relation between hemoglobin solutions, nitric oxide, and carbon monoxide is also summarized. Chapters are brief and headings divided by numbered outline points. An ample list of carefully selected references is provided. In addition, the authors strive to keep the list of references as current as possible. The table of contents provides only chapter headings and authors. A small but adequate index is provided. Illustrations are infrequent but of adequate quality (black-and-white) when provided.
Assessment: This book is a compact and effective educational tool. It is nicely organized to bring even the inexperienced reader up to speed with contemporary problems facing workers interested in the development and application of blood substitute technology.

Doody's Review Service

3 Stars from Doody

This is a first edition of a hardbound collection of essays on topics related to the development of blood substitutes. Compiled are a series of chapters providing the foundation for didactic lectures on clinical and basic science issues related to blood substitute development. The format begins with fundamental concepts and epidemiology and proceeds to specific discussion of contemporary problems in this field. Clinicians and basic scientists with an interest in the clinical problem of resuscitation from various shock states are an appropriate audience for this work. The authors represent an international group of authorities; many are from University of California at San Diego. Twelve chapters make up this compact, attractive hardbound text. The presentations begin with an overview of recent literature (1995) describing developments in the field of blood substitutes followed by a description of the blood usage problem, the physiology of shock, and derangement of oxygen transport in this state. Next, the authors develop various issues surrounding biological effects of blood substitutes including interaction of hemoglobin with endotoxin and oxygen transport in the microcirculation. Recent understanding of the relation between hemoglobin solutions, nitric oxide, and carbon monoxide is also summarized. Chapters are brief and headings divided by numbered outline points. An ample list of carefully selected references is provided. In addition, the authors strive to keep the list of references as current as possible. The table of contents provides only chapter headings and authors. A small but adequate index is provided. Illustrations are infrequent but of adequate quality(black-and-white) when provided. This book is a compact and effective educational tool. It is nicely organized to bring even the inexperienced reader up to speed with contemporary problems facing workers interested in the development and application of blood substitute technology.

David J. Dries

A dozen essays by specialists in different disciplines concerned with developing artificial blood, who were invited to provide foundation documents for a March 1996 course given in San Diego. The topics range from such clinical concerns as what the target is to detailed descriptions of natural blood's interactions with nitric oxide, endotoxin, and carbon dioxide. One paper comprehensively reviews the research published in 1995. Of interest to researchers of course, but especially to vampires in this age of AIDS. Annotation c. Book News, Inc., Portland, OR (booknews.com)

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