Bioinformatics for Evolutionary Biologists: A Problems Approach

by Bernhard Haubold, Angelika Bïrsch-Haubold

Overview

Covers fundamental aspects of sequence analysis in evolutionary biology, such as sequence alignment, phylogeny reconstruction, and coalescent simulation

Covers the material exclusively through 400 computer problems to enable learning by doing

Offers solutions to all problems to encourage self-study at a pace determined by the student

Contains over 30 programs written specifically for this book, which are provided as source code for further study

Ensures long-term usability of the course material by concentrating on fundamental concepts and utilizing the UNIX command line

Product Details

ISBN-13:	9783319884240
Publisher:	Springer International Publishing
Publication date:	06/06/2019
Edition description:	Softcover reprint of the original 1st ed. 2017
Pages:	318
Product dimensions:	6.10(w) x 9.25(h) x (d)

About the Author

Bernhard Haubold studied Natural Sciences at Cambridge University, UK and completed his DPhil in Bacterial opulation Genetics at Oxford University, UK in 1998. After training as a Post-Doc at the Max-Planck-Institute for Chemical Ecology in Jena, Germany he worked in the biotech industry before taking on a professorship in Bioinformatics at the University of Applied Sciences, Weihenstephan, Germany in 2003. In 2008, he moved to his current post as a researcher at the Max-Planck-Institute for Evolutionary Biology in Plön, Germany. He also teaches Bioinformatics at Lübeck University. Together with Thomas Wiehe he is the author of Introduction to Computational Biology, An Evolutionary Approach, which was published by Birkhäuser in 2006.

Angelika Börsch-Haubold studied Pharmacy at Freiburg University, Germany and Pharmacology at Cambridge University, UK. She completed her DPhil in Pharmacology at Oxford University, UK in 1997, prior to remaining at Oxford for a junior research fellowship. From 2005 to 2008, she taught various courses at the University of Applied Sciences, Weihenstephan, Germany. From 2008 to 2014 she worked as a researcher at the Max-Planck-Institute for Evolutionary Biology in Plön, Germany. She has contributed teaching material to Science in School and was involved in translating the fifth edition of The Molecular Biology of the Cell into German.

Table of Contents

Part I Problems.- 1 The Unix Command Line.- 1.1 Getting Started.- 1.2 Files, Directories, and Programs.-1.3 Scripts.- 2 Optimal Alignment.- 2.1 Keeping Score.- 2.2 Construction.- 2.3 Application.- 3 Exact Matching.- 3.1 Keyword Trees.- 3.2 Suffix Trees.- 3.3 Suffix Arrays.- 3.4 Text Compression.- 4 Fast Alignment.- 4.1 Global.- 4.2 Local.- 4.3 Glocal.- 4.4 Assembly.- 4.5 Multiple Sequences.- 5 Evolution Between Species: Phylogeny.- 5.1 Trees of Life.- 5.2 Rooted Trees.- 5.3 Unrooted Trees.- 6 Evolution within Populations.- 6.1 Descent from One or Two Parents.- 6.2 The Coalescent.- 7 Interrogating and Storing Data.- 7.1 Statistics.- 7.2 Relational Databases.- Part II Answers. .- 1 The Unix Command Line.- 1.1 Getting Started.- 1.2 Files, Directories, and Programs.- 1.3 Scripts.- 2 Optimal Alignment.- 2.1 Keeping Score.- 2.2 Construction.- 2.3 Application.- 3 Exact Matching.- 3.1 Keyword Trees.- 3.2 Suffix Trees.- 3.3 Suffix Arrays.- 3.4 Text Compression.- 4 Fast Alignment.- 4.1 Global.- 4.2 Local.- 4.3 Glocal.- 4.4 Assembly.- 4.5 Multiple Sequences.- 5 Evolution Between Species: Phylogeny.- 5.1 Trees of Life.- 5.2 Rooted Trees.- 5.3 Unrooted Trees.- 6 Evolution within Populations.- 6.1 Descent from One or Two Parents.- 6.2 The Coalescent.- 7 Interrogating and Storing Data.- 7.1 Statistics.- 7.2 Relational Databases.- A. Unix Guide.- B. Programs.- B.1 Own.- B.2 Biobox.- B.3 Third-Party.- References.- Index

Editorial Reviews

The book includes more than 40 programs specifically designed for the course. Code is provided for three major operating systems (Unix/Linux, Windows, Mac OS), which omits any possible technological barriers the students may have. That fact along with 400 problems of different levels—from elementary to research—make it an invaluable textbook for evolutionary biology students studying bioinformatics.” (Stefka Tzanova, Computing Reviews, June, 2018)​

From the Publisher