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Overview
This book documents the fascinating history of radiological techniques that use contrast agents. The text includes many of the fundamental documentary sources that bring to life the social and scientific background of the discoveries, the personalities of the discoverers, and implementation of new technologies. Such agents when used with X-rays allow clinicians to distinguish anatomical structures with nearly identical densities. Focus is on urological and angiographic uses of contrast agents.
Key selling features:
- Documents and thoroughly references the history of contrast agent development
- Reviews the priority and importance of patents
- Discusses the role that important individual scientists and leading research institutions have played in technology development and implementation
Product Details
| ISBN-13: | 9780429787225 |
|---|---|
| Publisher: | CRC Press |
| Publication date: | 04/08/2019 |
| Sold by: | Barnes & Noble |
| Format: | eBook |
| Pages: | 338 |
| File size: | 4 MB |
About the Author
Christoph de Haën, born September 9, 1940 in Switzerland, studied chemistry and
biology in Lausanne, Zurich, and Rome, earning a master’s degree in chemistry
from the Swiss Federal Institute of Technology (ETH Zurich), followed by a PhD
in molecular biology at the same institution. After a postdoctoral fellowship in biochemistry
at the University of Washington, Seattle, he became research faculty at
the same institution, jointly appointed in the Departments of Medicine (Division of
Endocrinology and Metabolism) and Biochemistry. There he moved up the ranks to
Research Full Professor and Graduate Faculty. In mid-career he joined the Bracco
company, a worldwide active pharmaceutical corporation, headquartered in Milan,
Italy. There he held various leadership positions in global research and development,
including Head of the Milano Research Center and Scientific Advisor to the Bracco
Group of Companies. The principle field of activity was contrast agents for various
diagnostic imaging modalities. His publications span a wide variety of fields, including
social science ones. He retired in 2005 and lives in Switzerland.
Table of Contents
Contents
Preface......................................................................................................................vii
Acknowledgments......................................................................................................ix
Author........................................................................................................................xi
Chapter 1 Introduction...........................................................................................1
Chapter 2 Methodological Considerations.............................................................9
Historical and Sociological Perspectives..............................................9
Technological Innovation.................................................................... 13
The Analytical Model of Technology Genesis and Shaping............... 15
Chapter 3 Assembly of a Technological Vision for X-Ray Contrast Agents....... 33
Chapter 4 Uro-Angiographic Contrast Agents—The Holy Grail........................ 41
Technology Genesis Phase.................................................................. 41
History............................................................................................ 41
From Sodium Iodide to Uroselectan Sodium and
Methiodal Sodium..................................................................... 41
Contrasting Historical Interpretations..................................... 103
The Dynamics of Technology Genesis......................................... 109
The Failure of One-Dimensional Reductionism...................... 109
Technical Knowledge from Interference of Different
Knowledge Cultures................................................................ 113
Interference as Communication and Individuation of
Knowledge............................................................................... 119
The Emergence of a Technological Vision.............................. 122
Synchronization and Interference............................................124
The Functions of the Technological Vision............................. 125
Technology Espousal and Resistance...................................... 125
Technology-Shaping Phase............................................................... 126
History.......................................................................................... 126
Perfecting Ionic Uro-Angiographic Contrast Agents.............. 126
The Controversial Prehistory of Nonionic Contrast Agents....... 156
Nonionic Contrast Agents........................................................ 170
The Dynamics of Technology Shaping........................................ 211
The Failure of One-Dimensional Reductionism...................... 211
Technical Knowledge from Interference of Different
Knowledge Cultures................................................................ 215
Interference as Communication and Individuation of
Knowledge............................................................................... 221
The Emergence of a Technological Vision..............................224
Synchronization and Interference............................................227
The Function of the Technological Vision..............................228
Technology Espousal and Resistance......................................228
Technology Consolidation and Economization Phase......................229
History..........................................................................................229
The Search for a New Vision........................................................ 235
Chapter 5 Conclusions....................................................................................... 239
References.............................................................................................................. 247
Endnote..................................................................................................................287
Person Index..........................................................................................................307
Subject Index......................................................................................................... 317