Table of Contents
Contributors vii
Preface xi
Part 1 Molecular Signaling Mechanisms: From Pathways to Networks 1
1 Wnt Signal Production, Secretion, and Diffusion 3 Madelon M. Maurice and Hendrik C. Korswagen
2 Wnt Signaling at the Membrane 15 Gary Davidson and Christof Niehrs
3 Wnt Signal Transduction in the Cytoplasm: an Introduction to the Destruction Complex 33 Tony W. Chen, Heather A. Wallace, Yashi Ahmed, and Ethan Lee
4 An Overview of Gene Regulation by Wnt/β-Catenin Signaling 51 Chen U. Zhang and Ken M. Cadigan
5 Finding a Needle in a Genomic Haystack: Genome-Wide Approaches to Identify Wnt/TCF Transcriptional Targets 73 Chandan Bhambhani and Ken M. Cadigan
6 Introduction to β-Catenin-Independent Wnt Signaling Pathways 89 Susanne Kühl and Michael Kühl
7 Molecular Mechanisms of Wnt Pathway Specificity 101 Alexandra Schambony, Guido J.R. Zaman, and Folkert Verkaar
8 Modulation of Wnt Signaling by Endocytosis of Receptor Complexes 113 Akira Kikuchi, Shinji Matsumoto, Katsumi Fumoto, and Akira Sato
9 New Insights from Proteomic Analysis of Wnt Signaling 125 Matthew P. Walker, Dennis Goldfarb, and Michael B. Major
10 New Insights about Wnt/β-Catenin Pathway Mechanisms from Global siRNA Screens 137 Tenzin Gocha and Ramanuj DasGupta
11 Mathematical Models of Wnt Signaling Pathways 153 Michael Kühl, Barbara Kracher, Alexander Groß, and Hans A. Kestler
12 The Wnt’s Tale: On the Evolution of a Signaling Pathway 161 Jenifer C. Croce and Thomas W. Holstein
Part 2 Selected Key Molecules in Wnt Signaling 177
13 Secreted Wnt Inhibitors or Modulators 179 Paola Bovolenta, Anne-Kathrin Gorny, Pilar Esteve, and Herbert Steinbeisser
14 Frizzleds as G Protein-Coupled Receptors 195 Gunnar Schulte
15 Dishevelled at the Crossroads of Pathways 207 Vítìzslav Bryja and Ondøej Bernatík
16 β-Catenin: a Key Player in Both Cell Adhesion and Wnt Signaling 217 Jonathan Pettitt
17 Evolutionary Diversification of Vertebrate TCF/LEF Structure, Function, and Regulation 225 Stefan Hoppler and Marian L. Waterman
18 Insights from Structural Analysis of Protein–Protein Interactions by Wnt Pathway Components and Functional Multiprotein Complex Formation 239 Zhihong Cheng and Wenqing Xu
Part 3 Wnt Signaling in Embryonic Development and Adult Tissue Homeostasis 251
19 Wnt Signaling in Early Vertebrate Development: From Fertilization to Gastrulation 253 Eliza Zylkiewicz, Sergei Y. Sokol, and Stefan Hoppler
20 Wnt/β-Catenin Signaling in Embryonic Stem Cells: Insights into Early Mammalian Development 267 Kathryn C. Davidson
21 Wnt Signaling in Neural Development 279 Richard I. Dorsky
22 Wnt Signaling in Heart Organogenesis 293 Stefan Hoppler, Silvia Mazzotta, and Michael Kühl
23 Wnt Signaling in Kidney Organogenesis 303 Kimmo Halt and Seppo Vainio
24 Wnt Signaling Regulation of Tissue Architecture (EMT and MET) and Morphogenesis: Consequences for Colorectal and Liver Cancer 315 Theodora Fifis, Bang M. Tran, Renate H.M. Schwab, Timothy M. Johanson, Nadia Warner, Nick Barker, and Elizabeth Vincan
25 Wnt Signaling in Adult Stem Cells: Tissue Homeostasis and Regeneration 329 Frank J.T. Staal and Riccardo Fodde
26 Restoring Tissue Homeostasis: Wnt Signaling in Tissue Regeneration After Acute Injury 339 Günes Özhan and Gilbert Weidinger
Part 4 Wnt Signaling in Chronic Disease 357
27 Wnt Signaling and Colorectal Cancer 359 Kevin Myant and Owen J. Sansom
28 Wnt Signaling in Melanoma 369 Jamie N. Anastas and Andy J. Chien
29 Wnt Signaling in Mood and Psychotic Disorders 379 Stephen J. Haggarty, Karun Singh, Roy H. Perlis, and Rakesh Karmacharya
30 Neuropsychiatric Disease-Associated Genetic Variation in the Wnt Pathway 393 Stephen J. Haggarty, Karun Singh, Roy H. Perlis, and Rakesh Karmacharya
31 Wnt Signaling in Dementia 411 Stephen J. Haggarty
32 Therapeutic Targeting of the Wnt Signaling Network 421 Felicity Rudge and Trevor Dale
Index 445