Williams Hematology: The Red Cell and Its Diseases
608Williams Hematology: The Red Cell and Its Diseases
608Paperback
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Overview
When red blood cells do not have enough hemoglobin, oxygen cannot reach all parts of the body—as a result, organs start to malfunction and may lead to a host of issues including deformities, enlarged spleen, heart problems and other diseases. There are myriad red cell disorders, such as iron deficiency anemia, pernicious anemia, aplastic anemia, autoimmune hemolytic anemia, sickle cell, thalassemia and other hemoglobinopathies.
The Red Cells and its Diseases provides clinicians with a practical diagnostic and treatment framework for identifying and successfully managing acute, congenital, and chronic red blood cell disorders. Presented in an accessible template format, the book includes classifications, etiology and pathogenesis, clinical and laboratory features, differential diagnosis, treatment, management, and supportive care.
This comprehensive, yet concise resource covers:
- Structure and physiology of the red cell
- Classification of red cell diseases
- Diseases of red cell production
- Anemias resulting principally from inherited disorders
- Anemia as a result of exogenous factors
- Polyclonal erythrocytosis
- Red cell transfusion
Product Details
ISBN-13: | 9781264269075 |
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Publisher: | McGraw Hill LLC |
Publication date: | 11/05/2021 |
Pages: | 608 |
Product dimensions: | 5.90(w) x 9.00(h) x 0.90(d) |
About the Author
Josef T. Prchal, MD, is a professor in the division of hematology and hematologic malignancies, a Huntsman Cancer Institute investigator, and a member of the Cell Response and Regulation Program and the Imaging, Diagnostics, and Therapeutics Program at the University of Utah.
Marshall Lichtman, M.D.Professor of MedicineUniversity of Rochester School of MedicineRochester, NY
Table of Contents
Contributors ix
Preface xiii
Part I
Structure and Physiology of the Red Cell
1 Structure and Composition of the Erythrocyte Mohandas Narla 3
2 Erythropoiesis and Red Cell Turnover Josef T. Prchal Perumal Thiagarajan 21
Part II
Classification of Red Cell Diseases
3 Clinical Manifestations and Classification of Erythrocyte Disorders Josef T. Prchal 49
Part III
Diseases of Red Cell Production
4 Aplastic Anemia: Acquired and Inherited George B. Segel Marshall A. Lichtman 61
5 Pure Red Cell Aplasia Neal S. Young 91
6 Anemia of Chronic Disease Tomas Ganz 101
7 Erythropoietic Effects of Endocrine Disorders Xylina T. Gregg 111
8 Paroxysmal Nocturnal Hemoglobinuria Charles J. Parker 117
9 Folate, Cobalamin, and Megaloblastic Anemias Ralph Green 133
10 Iron Metabolism Tomas Ganz 169
11 Iron Deficiency and Overload Tomas Ganz 181
12 Anemia Resulting from other Nutritional Deficiencies Ralph Green Ananya Datta Mitra 205
13 Anemia Associated with Marrow Infiltration Vishnu V.B. Reddy Diana Morlote 213
Part IV
Anemias Resulting Principally from Inherited Disorders
14 The Hereditary Dyserythropoietic Anemias Achille Iolascon Roberta Russo Rami Khoriaty 219
15 Erythrocyte Membrane Disorders Theresa L. Coetzer 229
16 Erythrocyte Enzyme Disorders Marije Bartels Eduard J. van Beers Richard van Wijk 259
17 Thalassemia: A Disorder of Globin Synthesis Sujit Sheth Swee Lay Thein 295
18 Disorders of Hemoglobin Structure: Sickle Cell Anemia and other Hemoglobinopathies Vivien A. Sheehan Victor R. Gordeuk Abdullah Kutlar 335
19 Methemoglobinemia and other Dyshemoglobinemias Josef T. Prchal 371
20 Polyclonal and Hereditary Sideroblastic Anemias Amel Hamdi Josef T. Prchal 385
21 The Porphyrias John D. Phillips Karl E. Anderson 395
Part V
Anemia as a Result of Exogenous Factors
22 Fragmentation Hemolytic Anemia Kelty R. Baker Joel Moake 423
23 Erythrocyte Disorders as a Result of Toxic Agents Paul C. Herrmann 431
24 Hemolytic Anemia Resulting from Infections with Microorganisms Marshall A. Lichtman 437
25 Hypersplenism and Hyposplenism Srikanth Nagalla Jaime Caro 447
26 Hemolytic Anemia Resulting from Immune Injury Charles H. Packman 457
27 Alloimmune Hemolytic Disease of the Fetus and Newborn Ross M. Fasano Jeanne E. Hendrickson Naomi L.C. Luban 481
Part VI
Polyclonal Erythrocytosis
28 Primary and Secondary Erythrocytoses (Polycythemias) Josef T. Prchal 499
Part VII
Red Cell Transfusion
29 Erythrocyte Antigens and Antibodies Christine Lomas-Francis 521
30 Blood Procurement and Red Cell Transfusion Claudia S. Cohn Jeffrey McCullough Xiangrong He 545
Index 565