Volatile Biomarkers: Non-Invasive Diagnosis in Physiology and Medicine

by Cristina Davis (Editor), Jonathan Beauchamp (Editor)

Overview

Volatile organic compounds (VOCs) in exhaled breath, sweat or urine carry much information on the state of human health. The role of VOCs in clinical diagnosis and therapeutic monitoring is expected to become increasingly significant due to recent advances in the field. Volatile Biomarkers: Non-Invasive Diagnosis in Physiology and Medicine includes the latest discoveries and applications for VOCs from the world's foremost scientists and clinicians working in this emerging analytic area.

• Appeals to a multidisciplinary audience, including scientists, researchers, and clinicians with an interest in breath analysis
• Features the latest scientific research and technical breakthroughs in the diagnostic and therapeutic aspects of volatile organic compounds
• Includes case presentations documenting applications in multiple areas of human health and safety

Product Details

ISBN-13:	9780444626202
Publisher:	Elsevier Science
Publication date:	03/27/2013
Sold by:	Barnes & Noble
Format:	eBook
Pages:	600
File size:	18 MB
Note:	This product may take a few minutes to download.

About the Author

Cristina Davis is chair and professor of Mechanical and Aerospace Engineering at the University of California Davis, United States. Her research focuses on development of novel chemical and biological sensor systems and biomarker identification in agriculture and human/animal health monitoring. She has 12 issued patents and has coauthored over 100 peer-reviewed journal articles and book chapters. She is current chair-elect of IABR.
Jonathan Beauchamp is manager of the Emissions Analytics and Diagnostics group at the Fraunhofer Institute for Process Engineering and Packaging IVV in Freising, Germany. He has been involved in academic and industrial breath research for the past 15 years and is currently principal investigator in several breath-related projects. He is an active member and current treasurer of the International Association of Breath Research (IABR).

Table of Contents

A: Interpretation of Breath Analysis Data
  1. Mathematical and Statistical Approaches for Interpreting Biomarker Compounds in Exhaled Human Breath
  2. Issues and Challenges in Human Breath Research: Perspectives from Our Experience
B: Real-Time Analysis of Exhaled Breath
  3. Physiological Modeling for Analysis of Exhaled Breath
C: Physiological and Clinical Studies
  4. Recent SIFT-MS Studies of Volatile Compounds in Physiology, Medicine and Cell Biology
  5. The Analysis of Oral Air by Selected Ion Flow Tube Mass Spectrometry Using Indole and Methylindole as Examples
  6. Smokers Breath as Seen by Proton-Transfer-Reaction Time-of-Flight Mass Spectrometry (PTR-TOF-MS)
  7. Exhaled Breath Analysis in Occupational Medicine
  8. Volatile Organic Compounds in Human Breath: Biogenic Origin and Point-of-Care Analysis
Approaches
  9. Breath Analysis in Critically Ill Patients—Potential and Limitations
  10. Analysis of Cancer Biomarkers in Exhaled Breath and Comparison with Sensory Indications by Dogs
D: Nitric Oxide, No, and Carbon Monoxide, Co
  11. Added Value with Extended NO Analysis
  12. Carbon Monoxide as an Exhaled Biomarker of Pulmonary Diseases
  13. Exhaled Nitric Oxide in Clinical Practice: Recent Advances and New Challenges
E: Clinical Breath Tests
  14. An Update on 13C-Breath Tests: The Transition to Acceptability into Clinical Practice
F: Development and Use Of Sensors
  15. Sensors for Exhaled Gas Analysis: An Analytical Review
  16. Arrays of Nanomaterial-Based Sensors for Breath Testing
  17. Smart Sensor Systems for Human Health Breath Monitoring Applications
  18. VOC Analysis by SIFT-MS, GC-MS, and Electronic Nose for Diagnosing and Monitoring Disease
G: Exhaled Breath Condensate (Ebc) And Particulates
  19. Measurement of Biomarkers of Oxidative Stress and Airway Inflammation in Exhaled Breath Condensate: Methodology and Potential Applications in Patients with COPD and Healthy Smokers
  20. Particles in Exhaled Air—A Novel Method of Sampling Non-Volatiles in Exhaled Air
H: Volatiles Of Microbial Origin: Urine, Stool and In Vitro Cultures
  21. Challenges in the Investigation of Volatile Disease Biomarkers in Urine
  22. Volatile Organic Compounds (VOCs) Found in Urine and Stool
  23. Volatile Organic Compounds (VOCs) Released by Pathogenic Microorganisms in vitro: Potential Breath Biomarkers for Early-Stage Diagnosis of Disease
I: Urban Search and Rescue Operations
  24. Potential Applications of Volatile Organic Compounds in Safety and Security

What People are Saying About This

From the Publisher

A comprehensive review of the use of volatile biomarkers in exhaled breath and other bodily excretions for clinical diagnosis and therapeutic monitoring

Editorial Reviews

Reviewer: Valerie L Ng, PhD MD(Alameda County Medical Center/Highland Hospital)
Description: This book details the state of the art of breath analysis and VOCs (i.e., volatile organic compounds). This is an update of the field since the last major publication in this area was published in 2005.
Purpose: The purpose is to provide a current snapshot of breath analysis today. This worthy objective is somewhat met by the authors.
Audience: This book is intended for those interested in breath analysis or VOCs. This includes anyone performing research in this field and anyone interested in its application to human physiology and medicine (health versus disease).
Features: Who would have thought there was this much research on and biomedical applications for breath analysis? The book appropriately starts with a discussion of interpreting breath analyses, and readers quickly learn that the lack of standardization for specimen collection, patient preparation, or laboratory analytical methodology has greatly limited its applicability to assessing human health or disease. Once readers figure out this book is primarily about "proof of concept" and not immediate applicability to daily practice, it becomes an absolutely fascinating read about the many applications of VOC and breath analysis. Imagine an entire chapter about using VOC detection for urban search and rescue activities, or VOC analysis of microorganisms in urine or stool, or studies of VOCs in critically ill patients. This book nicely summarizes the current state of the art of VOC detection and analysis for a variety of interesting applications. I have three very minor negative comments. Chapters are uneven in style and could have benefited from a standard format. Chapters are also uneven in their use of references. Some have an exhaustive list of references and others only a few, and some are outdated or not the most relevant. I also stumbled onto an unfortunate misspelling resulting in a major change of context (chapter 21, p.395): the term "isovaleric academia" — after puzzling it out, it was clear "isovaleric acidemia" was intended.
Assessment: This is the book for you if you are engaged in this research or interested in the rapidly evolving field of VOC and breath analysis research.

Doody's Review Service

"The book appropriately starts with a discussion of interpreting breath analyses, and readers quickly learn that the lack of standardization for specimen collection, patient preparation, or laboratory analytical methodology has greatly limited its applicability to assessing human health or disease…This book nicely summarizes the current state of the art of VOC detection and analysis for a variety of interesting applications." —Doody.com, November 2013

"Volatile organic compounds are continuously generated by the human body and partially emitted in exhaled breath and through the skin, as well as other pathways…Medical, biological, chemical, and engineering specialists review developments in breath analysis since 2005, when the previous volume was completed." —Reference & Research Book News, October 2013

From the Publisher