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9780127098548
Vitamins and Hormones / Edition 1 available in Hardcover, eBook
- ISBN-10:
- 0127098542
- ISBN-13:
- 9780127098548
- Pub. Date:
- 03/02/1998
- Publisher:
- Elsevier Science
- ISBN-10:
- 0127098542
- ISBN-13:
- 9780127098548
- Pub. Date:
- 03/02/1998
- Publisher:
- Elsevier Science
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Overview
First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Editorial Board reflects expertise in the field of hormone action, vitamin action, X-ray, crystal structure, physiology, and enzyme mechanisms. This serial includes comprehensive and cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists, and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will also find this series indispensable.
Product Details
ISBN-13: | 9780127098548 |
---|---|
Publisher: | Elsevier Science |
Publication date: | 03/02/1998 |
Series: | Vitamins and Hormones , #54 |
Pages: | 234 |
Product dimensions: | 6.00(w) x 9.00(h) x (d) |
About the Author
Dr. Litwack has authored 3 textbooks on biochemistry and hormones (one with John Wiley & Sons and 2 with Academic Press/Elsevier) and he has edited more than 70 volumes in the Vitamins & Hormones series (Academic Press/Elsevier); he has edited 14 volumes entitled Biochemical Actions of Hormones (Academica Press); He has edited (with David Kritchevsky) Actions of Hormones on Molecular Processes (Academic Press)
Table of Contents
Contributors | xv | |
Preface | xix | |
1 | Reinterpretation of Basal Glucocorticoid Feedback: Implications to Behavioral and Metabolic Disease | |
I. | Glucocorticoid Hormones and a New Hypothesis of Glucocorticoid Feedback | 2 |
II. | Basal Glucocorticoid Feedback | 4 |
III. | What do Studies Using MR and GR Antagonists Tell Us about Glucocorticoid Feedback? | 7 |
IV. | CNS Lesion Studies and Presumed Sites of Glucocorticoid Feedback | 9 |
V. | Brain Exposure to Glucocorticoids: Feedback Sites Revealed? | 10 |
VI. | Acute Stress and Glucocorticoid Feedback | 11 |
VII. | Chronic Stress, the HPA Axis, and Energy Balance: Glucocorticoids Feed Back to Stimulate CRF Pathways and the HPA Axis | 11 |
VIII. | Glucocorticoids, the HPA Axis, and Energy Balance | 13 |
IX. | Feeding Restores Energy Balance and Blunts HPA, CRF, and Behavioral Responses to Stress | 15 |
X. | Reinterpretation of Basal Glucocorticoid Feedback: A Glucocorticoid-Metabolic-Brain Feedback Axis? | 18 |
XI. | Implications of the Glucocorticoid-Metabolic-Brain Feedback Axis | 20 |
References | 23 | |
2 | Activation of the Ligand-Mineralocorticoid Receptor Functional Unit by Ancient, Classical, and Novel Ligands. Structure-Activity Relationship | |
I. | Introduction | 32 |
II. | The Nuclear Receptor Superfamily | 34 |
III. | Steroid Receptors | 36 |
IV. | The Mineralocorticoid Effect | 37 |
V. | Structure-Activity Relationship for the Mineralocorticoid Effect | 40 |
VI. | Limitations of the Model | 45 |
VII. | Progesterone and Progesterone Derivatives | 46 |
VIII. | Extra-Adrenal Mineralocorticoid Agonists | 49 |
IX. | A Novel Synthetic Mineralocorticoid--11, 19-Oxidoprogesterone | 50 |
X. | Ligand-Dependent Cytoplasmic Trafficking of the MR | 52 |
XI. | Redox Milieu Regulates Ligand Binding to the MR and Receptor Bioavailability | 56 |
XII. | Envoy | 58 |
References | 62 | |
3 | Reciprocal Regulation and Integration of Signaling by Intracellular Calcium and Cyclic GMP | |
I. | Introduction | 70 |
II. | Regulation of [Ca superscript 2 + subscript i] by cGMP | 70 |
III. | Regulation of [cGMP subscript i] by Ca[superscript 2+] | 74 |
IV. | Cyclic GMP-Calcium Signaling and Cellular Physiology | 79 |
V. | Conclusions | 87 |
References | 88 | |
4 | Unusual Guanylyl Cyclases and cGMP Signaling in Dictyostelium Discoideum | |
I. | Introduction | 96 |
II. | cGMP Targets | 97 |
III. | cGMP Phosphodiesterases | 99 |
IV. | Guanylyl Cyclases | 100 |
V. | Desensitization of cGMP Response | 107 |
VI. | Translocation of sGC to the Membrane | 109 |
VII. | Phylogeny of the cGMP Pathway | 110 |
VIII. | Conclusions and Future Perspectives | 111 |
References | 111 | |
5 | CRH, Stress and Major Depression: A Psychobiological Interplay | |
I. | Major Depression: Clinical Characteristics and Etiology | 119 |
II. | CRH, the HPA Axis, and Stress | 121 |
III. | Major Depression and the HPA Axis | 124 |
IV. | HPA Axis, MDD, and Genetics | 132 |
V. | Early Trauma and HPA Axis Development | 140 |
VI. | Conclusion | 142 |
References | 143 | |
6 | Gonadotropin-Releasing Hormone Receptors: Structure, Expression, and Signaling Transduction | |
I. | Introduction | 152 |
II. | GnRH Receptors Belong to the Family of G-Protein-Coupled Receptors | 153 |
III. | GnRH Receptors Possess Unique Features | 156 |
IV. | GnRH Receptor is Expressed in Extrapituitary Tissues and Various Tumors | 159 |
V. | Multiple Transcripts of GnRH Receptor are Present in Human Pituitary and Tumors | 160 |
VI. | GnRH Analogues Suppress Tumor Growth | 161 |
VII. | Structure of the GnRH Receptor | 163 |
VIII. | Nonmammalian GnRH Receptors Differ from Mammalian GnRH Receptors | 167 |
IX. | Mammalian GnRH-II Receptor (Type II Receptor) Contains C-Terminal Domain | 168 |
X. | GnRH-II Stimulates FSH and LH Secretion by Activating GnRH-I Receptors | 171 |
XI. | GnRH Receptor Mutations in Patients with Hypogonadotropic Hypogonadism | 172 |
XII. | GnRH Mediates its Functions through Multiple Signaling Pathways | 174 |
XIII. | GnRH Regulates Expression of a Large Number of Downstream Signaling Genes | 179 |
References | 191 | |
7 | Familial Growth Hormone Deficiency and Mutations in the GHRH Receptor Gene | |
I. | Introduction | 210 |
II. | The GHRH Receptor and its Gene | 212 |
III. | Mutations in the GHRHR Gene | 213 |
IV. | Clinical, Hormonal, and Radiological Phenotype of Patients with Bi-Allelic GHRHR Mutations | 215 |
V. | Hormonal and Radiological Phenotype of Heterozygous Carriers | 217 |
VI. | Conclusions | 217 |
References | 218 | |
8 | The Roles of Phospholipase C-[gamma]1 and Actin-binding Protein Filamin A in Signal Transduction of the Insulin Receptor | |
I. | Introduction | 222 |
II. | Insulin Receptor Sequence and Structure Analysis | 222 |
III. | PLC[gamma]1 and Insulin Signaling | 229 |
IV. | Filamin A and Insulin Signaling | 235 |
V. | Conclusions | 240 |
References | 241 | |
9 | Regulation of Expression of the NA[superscript +]/H[superscript +] Exchanger by Thryoid Hormone | |
I. | Introduction | 250 |
II. | Psychological Significance of NHE1 | 251 |
III. | Na[superscript +]/H[superscript +] Exchanger Basic Structure | 254 |
IV. | General Aspects of Regulation of Expression of NHE1 | 255 |
V. | Initial Studies on Cloning and Characterization of the Mouse NHE1 Promoter | 256 |
VI. | Regulation of NHE1 by Thyroid Hormone | 257 |
VII. | Summary and Future Directions | 261 |
References | 262 | |
10 | Plasma Retinol-Binding Protein: Structure and Interactions with Retinol, Retinoids, and Transthyretin | |
I. | Introduction | 272 |
II. | High-Resolution Structure of Retinol-Binding Protein in Complex with Retinol | 276 |
III. | Structure of Apo Retinol-Binding Protein | 281 |
IV. | Structure of Retinol-Binding Protein in Complex with Retinoids | 283 |
V. | Structure of the Retinol-Binding Protein-Transthyretin Complex | 287 |
VI. | Summary and Conclusions | 291 |
References | 292 | |
11 | Role of Magnesium, Coenzyme Q[subscript 10], Riboflavin, and Vitamin B[subscript 12] in Migraine Prophylaxis | |
I. | Introduction | 298 |
II. | Magnesium | 300 |
III. | Coenzyme Q[subscript 10] | 301 |
IV. | Riboflavin | 302 |
V. | Vitamin B[subscript 12] and Homocysteine | 303 |
VI. | Conclusions | 307 |
References | 308 | |
Index | 313 |
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