Vitamin D, An Issue of Rheumatic Disease Clinics
This issue features internationally renowned experts who have provided their expertise on a variety of topics related to the importance of vitamin D. It was not until feed back loops were identified between Vitamin D production and parathyroid hormone, phosphate that it earned its place as a true endocrine hormone. Current social and economic conditions have brought it back into the limelight with outbreaks of rickets and osteomalacia even in developed countries. However its complex regulation, together with the identification and characterization of the vitamin D receptor and its role in influencing multiple genetic pathways and function has heralded a new era highlighting its importance in health and disease. This includes its role in auto immune diseases such as multiple sclerosis, diabetes mellitus, cancer especially breast and prostate, skin, neurological and cognitive disorders and infectious diseases such as tuberculosis. We now know that adequate levels of vitamin D it is important in preventing falls and fracture. The need for supplementation and the amount recommended has also changed considerably from what we previously considered sufficient. The ongoing development of selective active analogs of vitamin D targeted to specific organs and function leads to the exciting possibility of improving outcomes of diseases associated with vitamin D regulation.
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Vitamin D, An Issue of Rheumatic Disease Clinics
This issue features internationally renowned experts who have provided their expertise on a variety of topics related to the importance of vitamin D. It was not until feed back loops were identified between Vitamin D production and parathyroid hormone, phosphate that it earned its place as a true endocrine hormone. Current social and economic conditions have brought it back into the limelight with outbreaks of rickets and osteomalacia even in developed countries. However its complex regulation, together with the identification and characterization of the vitamin D receptor and its role in influencing multiple genetic pathways and function has heralded a new era highlighting its importance in health and disease. This includes its role in auto immune diseases such as multiple sclerosis, diabetes mellitus, cancer especially breast and prostate, skin, neurological and cognitive disorders and infectious diseases such as tuberculosis. We now know that adequate levels of vitamin D it is important in preventing falls and fracture. The need for supplementation and the amount recommended has also changed considerably from what we previously considered sufficient. The ongoing development of selective active analogs of vitamin D targeted to specific organs and function leads to the exciting possibility of improving outcomes of diseases associated with vitamin D regulation.
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Vitamin D, An Issue of Rheumatic Disease Clinics

Vitamin D, An Issue of Rheumatic Disease Clinics

by Sol Epstein MD
Vitamin D, An Issue of Rheumatic Disease Clinics

Vitamin D, An Issue of Rheumatic Disease Clinics

by Sol Epstein MD

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Overview

This issue features internationally renowned experts who have provided their expertise on a variety of topics related to the importance of vitamin D. It was not until feed back loops were identified between Vitamin D production and parathyroid hormone, phosphate that it earned its place as a true endocrine hormone. Current social and economic conditions have brought it back into the limelight with outbreaks of rickets and osteomalacia even in developed countries. However its complex regulation, together with the identification and characterization of the vitamin D receptor and its role in influencing multiple genetic pathways and function has heralded a new era highlighting its importance in health and disease. This includes its role in auto immune diseases such as multiple sclerosis, diabetes mellitus, cancer especially breast and prostate, skin, neurological and cognitive disorders and infectious diseases such as tuberculosis. We now know that adequate levels of vitamin D it is important in preventing falls and fracture. The need for supplementation and the amount recommended has also changed considerably from what we previously considered sufficient. The ongoing development of selective active analogs of vitamin D targeted to specific organs and function leads to the exciting possibility of improving outcomes of diseases associated with vitamin D regulation.

Product Details

ISBN-13: 9781455743131
Publisher: Elsevier Health Sciences
Publication date: 02/28/2012
Series: The Clinics: Internal Medicine , #38
Sold by: Barnes & Noble
Format: eBook
File size: 3 MB

Table of Contents

Preface Sol Epstein xiii

Vitamin D: Metabolism Sylvia Christakos Dare V. Ajibade Puneet Dhawan Adam J. Fechner Leila J. Mady 1

The Vitamin D Receptor: New Paradigms for the Regulation of Gene Expression by1,25-Dihydroxyvitamin D3 J. Wesley Pike Mark B. Meyer 13

Assessment and Interpretation of Circulating 25-Hydroxyvitamin D and 1,25-Dihydroxyvitamin D in the Clinical Environment Bruce W. Hollis 29

Low Vitamin D Status: Definition, Prevalence, Consequences, and Correction Neil Binkley Rekha Ramamurthy Diane Krueger 45

Maternal Vitamin D Status: Implications for the Development of Infantile Nutritional Rickets Kebashni Thandrayen John M. Pettifor 61

Osteomalacia as a Result of Vitamin D Deficiency Arti Bhan Ajay D. Rao D. Sudhaker Rao 81

Genetic Disorders and Defects in Vitamin D Action Peter J. Malloy David Feldman 93

Vitamin D and Fracture Prevention Heike A. Bischoff-Ferrari 107

Vitamin D in Kidney Disease: Pathophysiology and the Utility of Treatment Rizwan A. Qazi Kevin J. Martin 115

Vitamin D and the Immune System: New Perspectives on an Old Theme Martin Hewison 125

Vitamin D: Extraskeletal Health Michael F. Holick 141

The Role of Vitamin D in Cancer Prevention and Treatment Aruna V. Krishnan Donald L. Trump Candace S. Johnson David Feldman 161

Vitamin D and Diabetes Tatiana Takiishi Conny Gysemans Roger Bouillon Chantal Mathieu 179

Vitamin D Analogs Glenville Jones 207

Index 233

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