Uveitis / Edition 2

by Sunir J. Garg

Overview

Developed at Philadelphia’s world-renowned Wills Eye Hospital, the Color Atlas and Synopsis of Clinical Ophthalmology series covers the most clinically relevant aspects of ophthalmology in a highly visual, easy-to-use format. Vibrant, full-color photos and a consistent outline structure present a succinct, high-yield approach to the seven topics covered by this popular series: Cornea, Retina, Glaucoma, Oculoplastics, Neuro-Ophthalmology, Pediatrics, and Uveitis . This in-depth, focused approach makes each volume an excellent companion to the larger Wills Eye Manual as well as a practical stand-alone reference for students, residents, and practitioners in every area of ophthalmology.

The updated Uveitis volume includes:

• Authoritative information on all the major aspects of ocular inflammatory disease, including both ocular and systemic manifestations of each disorder, ideal for busy practicing ophthalmologists, ocular immunologists, residents, and rheumatologists.
• More examples and variations of disease, clinical illustrations using new imaging modalities, and expanded treatment options.
• Newly characterized conditions, such as uveitis due to Ebola virus and Zika virus.
• More than 450 new and updated high-quality illustrations that detail the clinical features of each disorder, illustrate pathogenesis, and assist in visual diagnosis.
• An easy-to-use format that covers Epidemiology and Etiology, History, Physical Examination, Differential Diagnosis, Laboratory and Special Examinations, Diagnosis, Prognosis, and Management.

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Product Details

ISBN-13:	9781496363008
Publisher:	LWW
Publication date:	06/02/2018
Series:	Color Atlas and Synopsis of Clinical Ophthalmology
Edition description:	Second
Pages:	522
Product dimensions:	6.00(w) x 9.00(h) x 0.70(d)

Table of Contents

Editors vi

Contributors vii

About the Series xii

Preface xiii

Acknowledgments xiv

Chapter 1 Immune Response Overview Sunir J. Garg 2

Basic Concepts 2

Building Blocks of the Immune Response 3

Plasma-Derived Enzyme Systems: The Complement System 6

Hypersensitivity Reactions 6

Immunity and the Eye 7

Chapter 2 Anatomic Classification of Uveitis Wendy M. Smith Lisa J. Faia Sunir J. Garg H. Nida Sen 8

Classification 8

Sun Terminology for Activity of Uveitis 13

Chapter 3 Episcleritis, Scleritis, and Keratitis Shilpa Kodati H. Nida Sen Theresa Larson S. R. Rathinam Rajesh Vedanayaki Muhammad Rakibuz-Zaman William Hodge Somasheila I. Murthy Swapnali Sabhapandit Roxana Ursea 14

Episcleritis 14

Scleritis 16

Anterior Scleritis 16

Posterior Scleritis 18

Phylectenulosis 24

Herpetic Keratouveitis 28

Herpes Simplex Virus 28

Varicella Zoster Virus 32

Mooren Ulcer 34

Peripheral Ulcerative Keratitis 40

Chapter 4 Anterior Uveitis Julie Gueudry Bahram Bodaghi Phuc LeHoang Karina Julian Sunir J. Garg Sonia Mehta 46

Human Leukocyte Antigen B27-Associated Uveitis 46

Posner-Schlossman Syndrome 52

Fuchs Uveitis (Fuchs Heterochromic Iridocyclitis) 54

Juvenile Idiopathic Arthritis-Associated Uveitis (Juvenile Rheumatoid/Chronic Arthritis) 57

Tubulointerstitial Nephritis and Uveitis Syndrome 65

Chapter 5 Cataract-and Lens-Induced Uveitis Swapnali Sabhapandit Somasheila I. Murthy Mayank Mahajan Anita Schadlu 68

Phacoantigenic/Phacoanaphylactic/Phacolytic Uveitis 68

Lens-Induced Uveitis 68

Cataract Surgery-Related Uveitis 72

Chapter 6 Intermediate Uveitis Andrea D. Birnbaum Anjum F. Koreishi Debra A. Goldstein 76

Chapter 7 Posterior Uveitis and Collagen Vascular Diseases Sapna Gangaputra H. Nida Sen Rishi R. Doshi S. R. Rathinam Emmett T. Cunningham, Jr. Sunir J. Garg Robert W. Wong S. R. Rathinam Virginia Miraldi Utz Johnny Tang Jyotirmay Biswas Parthopratim Dutta Majumder Keith Wrobkwski Bhagya Sudheer T. Radhika Julie Lew Shree Kurup 84

Sarcoidosis-Associated Uveitis 84

Sympathetic Ophthalmia 92

Vogt-Koyanagi-Harada Syndrome 96

Ocular Complications of Rheumatoid Arthritis 102

Behçet Disease 106

Systemic Lupus Erythematosus 112

Antiphospholipid Syndrome 118

Eales Disease 124

Granulomatosis with Polyangiitis (Previously Called Wegener Granulomatosis) 128

Kawasaki Disease 132

Relapsing Polychondritis 134

Scleroderma 138

Dermatomyositis and Polymyositis 144

Polyarteritis Nodosa 148

Chapter 8 White Dot Syndromes Céline Terrada Bahram Bodaghi Kisha D. Piggott P. Kumar Rao Sapna Gangaputra Matthew A. Cunningham Steven Yeh Annal D. Meleth Jaclyn L. Kovach Janet L. Davis Jason Hsu 150

Acute Posterior Multifocal Placoid Pigment Epitheliopathy 150

Serpiginous Chorioretinopathy 154

Multiple Evanescent White Dot Syndrome 158

Multifocal Choroiditis/Subretinal Fibrosis and Uveitis Syndrome 162

Punctuate Inner Choroidopathy 168

Acute Zonal Occult Outer Retinopathy 172

Ocular Histoplasmosis Syndrome 174

Birdshot Chorioretinopathy (Vitiliginous Chorioretinitis) 180

Acute Macular Neuroretinopathy 186

Unilateral Acute Idiopathic Maculopathy 188

Acute Retinal Pigment Epitheliitis 192

Chapter 9 Infectious Posterior Uveitis Karina Julian Julie Gueudry Bahram Bodaghi Phuc LeHoang P. Vijayalakshmi Rim Kahloun Moncef Khairallah Sunir J. Garg JP Dunn Lalitha Prajna S. R. Rathinam T. Radhika Bryn Burkholder Shilpa Kodati H Nida Sen Julie Gueudry R. Vedhanayaki Vishali Gupta Sarakshi Mahajan Sapna Gangaputra Chloe Gottlieb Uwe Pleyer Valérie Touitou Carlos Alexandre de Amorim Garcia Filho Carlos Alexandre de Amorim Garcia Jason F. Okulicz Kim Ramasamy Priya S. Rajesh 196

Viral Infection 196

Herpetic 196

Acute Retinal Necrosis Syndrome 196

Progressive Outer Retinal Necrosis 200

Congenital Rubella Syndrome 206

West Nile Virus 210

Chikungunya 216

Ebola Virus Disease 220

Zika Virus 222

Spirochetes 226

Syphilis 226

Lyme Disease 234

Leptospirosis 238

Mycobacteria 242

Intraocular Tuberculosis 242

Leprosy (Hansen)-Associated Uveitis 248

Parasites, Bacteria, Fungi, and Nematodes 254

Ocular Toxoplasmosis 254

Ocular Toxocariasis 258

Cat-Scratch Disease 262

Whipple Disease 268

Diffuse Unilateral Subacute Neuroretinitis 272

Onchocerciasis 278

Loiasis 284

Ocular Cysticercosis 288

Rhinosporidiosis 292

Chapter 10 Endophthalmitis Stephen G. Schwartz Harry W. Flynn, Jr. Roy D. Brod Manahar Babu Balasundaram S. R. Rathinam Bahram Bodaghi Phuc LeHoang 296

Postoperative Endophthalmitis 296

Acute-Onset Postoperative Endophthalmitis 296

Delayed-Onset (Chronic) Postoperative Endophthalmitis 300

Filtering Bleb-Associated Endophthalmitis 303

Endogenous Endophthalmitis 306

Endogenous Fungal Endophthalmitis 312

Chapter 11 AIDS-Related Eye Disease Annal Meleth Sapna Gangaputra H. Nida Sen 318

HIV Retinopathy 318

Cytomegalovirus Retinitis 320

Immune Recovery Uveitis 328

Progressive Outer Retinal Necrosis 329

Fungal Retinitis 332

Pneumocystis Carinii Choroiditis 334

Kaposi Sarcoma 334

Chapter 12 Drug-Induced Uveitis Kara C. LaMattina Nehali V. Saraiya Debra A. Goldstein 338

Antimicrobials 339

Rifabutin 339

Cidofovir 339

Sulfonamides 340

Fluoroquinolones 344

Vancomycin 344

Bisphosphonates 348

Ocular Hypotensive Drugs 350

Metipranolol 350

Brimonidine 350

Prostaglandin Analogues 352

Biologic Agents 353

Tumor Necrosis Factor Inhibitors 353

Anti-Vascular Endothelial Growth Factor Agents 354

Immune Checkpoint Inhibitors 355

Chapter 13 Masquerade Syndromes H. Nida Sen Bahram Bodaghi Carol L. Shields Henry Wiley Sapna Gangaputra Ann O. Igbre Sunir J. Garg 356

Primary Vitreoretinal Lymphoma 356

Retinoblastoma Simulating Uveitis 364

Metastatic Cancer 370

Retinitis Pigmentosa 374

Ocular Ischemic Syndrome 378

Autoimmune Retinopathy 382

Chapter 14 Treatment of Uveitis Sam S. Dahr Shilpa Kadati Theresa Larson H. Nida Sen 388

Local Therapy 388

Topical Therapy 388

Periocular Therapy 389

Intravitreal Therapy 392

Systemic Therapy 398

Steroids 398

Immunomodulatory Therapy 398

Antimetabolites 398

T-Cell Inhibitors 399

Alkylating Agents 399

Biologies 400

Index 402

Editorial Reviews

Reviewer: Samendra Kumar Karkhur, MD (Stanford University School of Medicine)
Description: This book in the Wills Eye Hospital Color Atlas and Synopsis of Clinical Ophthalmology covers ocular inflammation and uveitis. It provides a wonderful opportunity for students and general ophthalmologists to quickly update themselves regarding any uveitis etiology from the standpoint of clinical diagnosis and management.
Purpose: The aim is to provide an up-to-date, illustrated book that can serve as a reliable and quick reference on all the uveitis entities while providing the basis of ocular inflammation for clinicians, residents, and fellows. The book achieves this aim with its concise text and abundant photos. This is certainly a worthy objective, considering the paucity of time in a busy clinical practice as well as a tight residency or fellowship program. Presenting the material in online format adds value, increasing its accessibility and enhancing its visibility while multiplying the target audience. The online version provides easy-to-access information in an interactive format and opens the gates to the larger body of knowledge that this synopsis summarizes.
Audience: The audience is clinical practitioners in ophthalmology, residents, and fellows, and targets uveitis specialists. However, this book will be equally useful for other physicians wishing to brush up their knowledge about the various diseases that have uveitis manifestations. The book is so concise, illustrative, and informative that physicians without ophthalmology training can find it useful. The authors have decades of experience and are from around the world, which lends the book a global perspective.
Features: The book comprehensively covers every aspect of uveitis, ranging from the basic aspects of ocular immunology required to develop an understanding of the disease process to all the latest information on drug-induced uveitis. The topics are divided based on the anatomical location of uveitis, such as surface, anterior, or posterior, followed by discussions about various etiologies responsible for causing those morphological subtypes. There is very large section on infectious, AIDS-related, and drug-induced uveitis, which makes sense in light of research that has identified uveitis entities that were considered idiopathic in the past as having a specific etiology. The book is extremely engaging because it is precise, brief, and illustrated with high-quality pictures. The format, bulleted two-column text with abundant illustrations, is the strongest aspect of the book.
Assessment: This book and website are excellent. It is easy to write an elaborate textbook on this topic since there is so much information out there, but it is extremely difficult to write a concise synopsis intended for hurried readers that simultaneously keeps them engaged and provides lasting information. This book does just that.

Doody's Review Service

This book in the Wills Eye Hospital Color Atlas and Synopsis of Clinical Ophthalmology covers ocular inflammation and uveitis. It provides a wonderful opportunity for students and general ophthalmologists to quickly update themselves regarding any uveitis etiology from the standpoint of clinical diagnosis and management.
 
The aim is to provide an up-to-date, illustrated book that can serve as a reliable and quick reference on all the uveitis entities while providing the basis of ocular inflammation for clinicians, residents, and fellows. The book achieves this aim with its concise text and abundant photos. This is certainly a worthy objective, considering the paucity of time in a busy clinical practice as well as a tight residency or fellowship program. Presenting the material in online format adds value, increasing its accessibility and enhancing its visibility while multiplying the target audience. The online version provides easy-to-access information in an interactive format and opens the gates to the larger body of knowledge that this synopsis summarizes.
 
The audience is clinical practitioners in ophthalmology, residents, and fellows, and targets uveitis specialists. However, this book will be equally useful for other physicians wishing to brush up their knowledge about the various diseases that have uveitis manifestations. The book is so concise, illustrative, and informative that physicians without ophthalmology training can find it useful.
The authors have decades of experience and are from around the world, which lends the book a global perspective.
 
The book comprehensively covers every aspect of uveitis, ranging from the basic aspects of ocular immunology required to develop an understanding of the disease process to all the latest information on drug-induced uveitis. The topics are divided based on the anatomical location of uveitis, such as surface, anterior, or posterior, followed by discussions about various etiologies responsible for causing those morphological subtypes. There is very large section on infectious, AIDS-related, and drug-induced uveitis, which makes sense in light of research that has identified uveitis entities that were considered idiopathic in the past as having a specific etiology. The book is extremely engaging because it is precise, brief, and illustrated with high-quality pictures. The format, bulleted two-column text with abundant illustrations, is the strongest aspect of the book.
 
This book and website are excellent. It is easy to write an elaborate textbook on this topic since there is so much information out there, but it is extremely difficult to write a concise synopsis intended for hurried readers that simultaneously keeps them engaged and provides lasting information. This book does just that.
 
Weighted Numerical Score: 86 - 3 Stars

From the Publisher