Tumor Hypoxia

by Yun Zhong

Overview

Tumors often start out as a benign growth, but gradually progress toward the malignant stage over a relatively long period of time. Tumor progression results from accumulated genetic mutations and inheritable epigenetic modifications that enable clonal evolution and selection of new clonal populations of tumor cells with aggressive characteristics including metastasis and therapy resistance. Increasing amounts of experimental evidence suggests that tumor microenvironment play a significant role in directing clonal evolution and determining clonal cell fate, which eventually leads to emergence of malignant tumor cell clones. Hypoxia is the most commonly observed feature of tumor microenvironment. Tumor hypoxia is significantly associated with malignant progression and predicts poor patient outcomes. This book provides detailed and up-to-date treaties on the role of hypoxia as a major driving force in tumor microenvironment to elicit cellular adaptation and clonal selection via genetic mutations and epigenetic modifications, to facilitate cancer stem cell maintenance, to enhance metastasis, to augment therapy resistance, and to evade immune surveillance.

Product Details

ISBN-13:	9789813147317
Publisher:	World Scientific Publishing Company, Incorporated
Publication date:	02/23/2017
Pages:	320
Product dimensions:	6.10(w) x 9.10(h) x 0.80(d)

Table of Contents

Preface v

Chapter 1 Tumor Hypoxia and Radiotherapy Olivia J. Kelada David J. Carlson 1

Chapter 2 Post-translational Modifications of the Hypoxia Inducible Factors Ian Cartwright Chuan-Yuan Li 49

Chapter 3 Hypoxia and Metastasis Elizabeth C. Finger Amato J. Giaccia 69

Chapter 4 Hypoxia and Cancer Stem Cell Regulation Sofie Mohlin Annika Jögi Sven Påhlman 101

Chapter 5 Hypoxia and Senescence Yashi Gupta Scott M. Welford 127

Chapter 6 Hypoxic Reprograming of Tumor Metabolism, Matching Environmental Supply with Biosynthetic Demand Betina McNeil Ioanna Papandreou Nicholas C. Denko 147

Chapter 7 Regulation of DNA Repair by Hypoxia Yuhong Lu Peter M. Glazer 169

Chapter 8 Regulation of the Hypoxic Response by Non-coding RNAs Xin Huang 189

Chapter 9 Hypoxia-Induced Endoplasmic Reticulum Stress Chih-Chien Chou Rakesh Bam Zhifen Yang Justin L. Bui Dadi Jiang Albert C. Koong 225

Chapter 10 The Hypoxic Tumor Microenvironment and the Anti-cancer Immune Response Joseph Barbi Fan Pan 249

Index 293