Tuberculosis Host-Pathogen Interactions

by Jeffrey D. Cirillo (Editor), Ying Kong (Editor)

Overview

This book summarizes the progress in studies of tuberculosis host-pathogen interactions from several perspectives: molecular microbiology, immunology, animal models, clinical studies, epidemiology, and drug discovery.

Tuberculosis (TB) remains a severe global public health problem. Complex interactions between environmental, microbial and host factors lead to clinically relevant infections.  Studies on bacterial virulence, host-genetic, and immunological factors contributing to the susceptibility to TB provide an ever-growing foundation of knowledge that is critical to finding new interventions.  Studies of immune mechanisms against M. tuberculosis infection have identified immunological markers associated with specific phenotypes in the host, providing insight into how they may be used to augment current treatment strategies. Recent advances in diagnosis, therapeutics and vaccines, as well as basic-research oriented studies have shed light on the development of new directions for prevention, treatment and control of TB. Improved understanding of the interplay between the bacterium and host is a key component of reducing incidence worldwide. 

Product Details

ISBN-13:	9783030253813
Publisher:	Springer-Verlag New York, LLC
Publication date:	09/10/2019
Sold by:	Barnes & Noble
Format:	eBook
File size:	18 MB
Note:	This product may take a few minutes to download.

About the Author

Dr. Jeffrey D. Cirillo is a Regents’ Professor at Texas A&M University College of Medicine and the Director of the Center for Airborne Pathogens Research and Imaging with over 30 years of research in tuberculosis.
Dr. Ying Kong is an Assistant Professor at the University of Tennessee Health Science Center with over 16 years of research in tuberculosis.

Table of Contents

1.Cell Wall Biosynthesis and Latency During Tuberculosis Infections.- 2. The Silent Plague: Regulation of Latent Tuberculosis Infections.- 3. Trehalose Dimycolate (Cord Factor) as a Contributing Factor to Tuberculosis Pathogenesis.- 4. Role of Myeloid-derived Suppressor Cells and Regulatory T-cells in the Tuberculous Granuloma.- 5. Interactions of Mycobacterium tuberculosis with Human Mesenchymal Stem Cells.- 6. Role of Mycobacterium tuberculosis PE and PPE proteins in pathogen-host interactions.- 7. Co-Infection with TB and HIV: Converging Epidemics, Clinical Challenges, and Microbial Synergy.- 8. Optical In Vivo Imaging in Tuberculosis Research.- 9. Mycobacteria Infection and Lipid Droplets – Host and Pathogen Stealing, Sharing and Storing Fat.- 10. Potential Immunology, Transcriptomics and Epigenomic Prediction Tools of the Future to Improve Tuberculosis Control.

Editorial Reviews

Reviewer: Carlos E Figueroa Castro, MD (Medical College of Wisconsin)
Description: This is a compendium of reviews covering the basics of tuberculosis pathogenesis and the interaction with the human host.
Purpose: The authors' aim to present novel findings in this area by covering different aspects including intrinsic factors like cord factor, PE and PPE proteins, and lipid metabolism, and the interaction between Mycobacterium tuberculosis and the immune system. The authors describe the challenges of performing a concise review of the field, especially with the availability of other books in this area, some of them acknowledged by the authors.
Audience: This book has a very small audience, namely researchers in the field of tuberculosis pathogenesis. Clinicians do not need to worry about purchasing this book, but the chapters on latent tuberculosis and HIV/tuberculosis coinfection are the more accessible. The authors have a good deal of expertise in the field.
Features: This book examines the role of various mechanisms, like cord factor, PE and PPE proteins, along with the strategies that allow this organism to survive the multipronged attack of the immune system, including the special cases of latent infection and the synergistic effect of HIV infection in tuberculosis pathogenesis. Some chapters are dedicated to novel techniques, like optical in vivo imaging and transcriptomics for tuberculosis control. The organization is logical, and duplication of material is low, with some exceptions. The book could have benefited from more illustrations, given the amount of immunology jargon, and the quality could be better (shadow effects, inconsistent use of fonts, three different depictions of a granuloma).
Assessment: This will be useful to seasoned researchers who want a review of the field and to learn about recent advances. It would be a difficult book for novice researchers, but the authors provide some references that might be more suitable as introductions to the field in the preface.

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