Treatment Response and Resistance in Schizophrenia

by Oliver Howes (Editor)

Overview

Treatment resistant schizophrenia (TRS) is common, affecting approximately a third of patients diagnosed. Despite the prevalence of TRS, the best approach to practical management is often unclear to clinicians and patients.

Treatment Response and Resistance in Schizophrenia offers a practical, clinically focused guide to TRS and the real-world challenges faced by those impacted. Over 14 chapters this resource covers the principles and practice of TRS, from the definition, epidemiology, and clinical assessment, to the pharmacological, physical, and psychological management of treatment resistance.

All chapters have been written by internationally leading experts in the field to ensure busy clinicians have high-quality, applicable content that is rooted in real clinical experiences. A chapter of case studies is included to link real-life scenarios to each of the instructive chapters, illustrating approaches to practical management and application.

Part of the Oxford Psychiatry Library, this useful pocket book is an invaluable resource and quick reference for psychiatrists, psychiatry trainees, and other mental health practitioners, as well as clinical psychologists, primary care physicians, and specialist nurses.

Product Details

ISBN-13:	9780198828761
Publisher:	Oxford University Press
Publication date:	10/20/2018
Series:	Oxford Psychiatry Library
Pages:	218
Product dimensions:	8.40(w) x 5.40(h) x 0.50(d)

About the Author

Oliver Howes, King's College London, London, Professor of Molecular Psychiatry

Table of Contents

1. Introduction, Oliver Howes2. Treatment response and resistance in schizophrenia: principles and definition, Robert McCutcheon, Christoph Correll, Oliver Howes, and John Kane3. Maximizing response to first-line antipsychotics in Schizophrenia, Robert C. Smith, Stefan Leucht, and John M. Davis4. Epidemiology, impact and predictors of treatment resistant schizophrenia, John Lally and James H. MacCabe5. The neurobiology of antipsychotic treatment response and resistance, Stephen J. Kaar, Steven Potkin, and Oliver Howes6. Pharmacological management of TRS: Fundamentals of clozapine, Yvonne S. Yang, and Stephen R. Marder7. Managing common adverse-effect of clozapine, Christopher Rohde and Jimmi Nielsen8. Pharmacological management of treatment-resistant schizophrenia: advanced use of clozapine, Siobhan Gee and David Taylor9. Pharmacological management of TRS: alternatives to clozapine, Thomas R. E. Barnes10. Psychosis and the family: the role of family interventions, Juliana Onwumere and Elizabeth Kuipers11. Cognitive behavioral therapy for psychosis, Majella Byrne, Suzanne Jolley & Emmanuelle Peters12. Ultra treatment resistance, Gary Remington, Ofer Agid, Hiroyoshi Takeuchi, Jimmy Lee, Araba Chintoh13. Illustrative case studies, Ofer Agid, Thomas Barnes, Majella Byrne, Araba Chintoh, Christoph Correll, Siobhan Gee, Oliver Howes, Suzanne Jolley, John Lally, Jimmy Lee, John Kane, James MacCabe, Stephen R. Marder, Robert McCutcheon, Jimmi Nielsen, Emmanuelle Peters, Gary Remington, Christopher Rohde, Hiroyoshi Takeuchi, David Taylor, and Yvonne S. Yang14. Novel treatments and future directions, Seiya Miyamoto and Nobumi Miyake

Editorial Reviews

Reviewer: Aaron John Plattner, MD (Network180 )
Description: This book reviews concepts of how to correctly identify treatment response or treatment nonresponse in patients with schizophrenia and provides a guide to treatment options for treatment-resistant schizophrenia.
Purpose: The author notes the high prevalence of treatment-resistant schizophrenia and the lack of clear guidance for how to manage this difficult condition as the impetus for this book, which addresses this problem with the most relevant evidence-based treatment strategies. This book reviews and presents the available data clearly.
Audience: The book is intended as a guide "for psychiatrists, psychiatry trainees, and other mental health practitioners, as well as clinical psychologists, primary care physicians, and specialist nurses." While all these readers can certainly benefit, this book will be most useful for those who treat people who suffer from schizophrenia primarily with psychopharmacology. The author enlists several experts to contribute in their respective areas.
Features: The 14 chapters define treatment response and nonresponse in patients with schizophrenia, the appropriate use of clozapine including prescribing strategies and managing its side effects, the available data on augmentation strategies of clozapine, and other nonpharmacological treatment options such as family intervention and CBT. Each chapter begins with key points, has multiple graphics, and ends with the references.
Assessment: As an inpatient psychiatrist who focuses primarily on patients with psychotic symptoms, I found this book to be a vital resource. It is easy to read and concise, yet complete, thus serving as a helpful guide. Providers can feel confident that it will be sufficient to assist them in the treatment of patients who do not respond to the more commonly prescribed antipsychotics. A future edition will be needed, as data continues to emerge about other treatment strategies, specifically clozapine augmentation or alternatives when clozapine does not elicit an appropriate treatment response.

Doody's Review Service

"As an inpatient psychiatrist who focuses primarily on patients with psychotic symptoms, I found this book to be a vital resource. It is easy to read and concise, yet complete, thus serving as a helpful guide. Providers can feel confident that it will be sufficient to assist them in the treatment of patients who do not respond to the more commonly prescribed antipsychotics." — Doody's Review

From the Publisher