Translational Control in Biology and Medicine / Edition 3

by Michael B. Mathews, Nahum Sonenberg, John W. B. Hershey

Overview

The new edition of this successful monograph has been both updated and broadened. Since the previous (second) edition was published in 2000, the structures of the bacterial and eukaryotic ribosomes have been published, advancing our basic understanding of translation and mechanisms involving protein and RNA regulators. In addition, as the title indicates, this edition has a new focus on the role of translational control in human development and disease. This book, with 30 chapters written by experts in the field, is essential reading for anyone interested in the process of translation, its regulation, and how its failure can be the cause of disease.

Product Details

ISBN-13:	9780879697679
Publisher:	Cold Spring Harbor Laboratory Press
Publication date:	11/29/2006
Series:	Monograph Series
Pages:	944
Product dimensions:	6.10(w) x 9.10(h) x 1.70(d)

Table of Contents

Preface     ix
Origins and Principles of Translational Control   M.B. Mathews   N. Sonenberg   J.W.B. Hershey     1
Structure of the Bacterial Ribosome and Some Implications for Translational Regulation   H.F. Noller     41
Structure and Function of the Eukaryotic Ribosome and Elongation Factors   D.J. Taylor   J. Frank   T.G. Kinzy     59
The Mechanism of Translation Initiation in Eukaryotes   T.V. Pestova   J.R. Lorsch   C.U.T. Hellen     87
Translation Initiation by Viral Internal Ribosome Entry Sites   J.A. Doudna   P. Sarnow     129
Translation Initiation via Cellular Internal Ribosome Entry Sites   O. Elroy-Stein   W.C. Merrick     155
Translation Termination, the Prion [PSI[superscript +]], and Ribosomal Recycling   M. Ehrenberg   V. Hauryliuk   C.G. Crist   Y. Nakamura     173
Coupled Termination-Reinitiation Events in mRNA Translation   R.J. Jackson   A. Kaminski   T.A.A. Poyry     197
Mechanism of Translation Initiation in the Yeast Saccharomyces cerevisiae   A.G. Hinnebusch   T.E. Dever   K. Asano     225
cis-Regulatory Sequences and trans-ActingFactors in Translational Control   M.W. Hentze   F. Gebauer   T. Preiss     269
Regulation of mRNA Molecules by MicroRNAs   K.A. Wehner   P. Sarnow     297
The elF2[alpha] Kinases   T.E. Dever   A.C. Dar   F. Sicheri     319
elF2[alpha] Phosphorylation in Cellular Stress Responses and Disease   D. Ron   H.P. Harding     345
Signaling to Translation Initiation   B. Raught   A.-C. Gingras     369
Translational Control in Cancer Development and Progression   R.J. Schneider   N. Sonenberg     401
Matters of Life and Death: Translation Initiation during Apoptosis   S.J. Morley   M.J. Coldwell     433
Translational Control in Metabolic Diseases: The Role of mTOR Signaling in Obesity and Diabetes   S.C. Kozma   S.H. Um   G. Thomas     459
Translational Control of Synaptic Plasticity and Learning and Memory   E. Klann   J.D. Richter     485
Translational Control in Development   B. Thompson   M. Wickens   J. Kimble     507
Protein Synthesis and Translational Control during Viral Infection   I.J. Mohr   T. Pe'ery   M.B. Mathews      545
Regulation of Translation Elongation and the Cotranslational Protein Targeting Pathway   T.P. Herbert   C.G. Proud     601
Regulation of Termination and Recoding   J.D. Dinman   M.J. Berry     625
Nonsense-mediated mRNA Decay: From Yeast to Metazoans   A. Jacobson   E. Izaurralde     655
Localized Translation through Messenger RNA Localization   E.R. Gavis   R.H. Singer   S. Huttelmaier     689
The Interface between mRNA Turnover and Translational Control   C.I. Gonzalez   C.J. Wilusz   J. Wilusz     719
Translational Control in Plants and Chloroplasts   D.R. Gallie     747
Mitochondrial Translation and Human Disease   E.A. Shoubridge   F. Sasarman     775
Translational Control in Prokaryotes   P. Romby   M. Springer     803
Noncanonical Functions of Aminoacyl-tRNA Synthetases in Translational Control   P.L. Fox   P.S. Ray   A. Arif   J. Jia     829
Therapeutic Opportunities in Translation   J. Pelletier   S. W. Peltz     855
Index     897

Editorial Reviews

This is a very useful volume for all those who know or suspect that transcriptional control of their favourite gene may not be the complete story.

Society for General Microbiology Quarterly

The editors are to be congratulated on assembling an outstanding collection of contributions and contributors. While which chapters you choose to read will undoubtedly reflect your specific interests, I would encourage all to read the opening chapter written by the editors where they provide a highly readable review of the origins, mechanisms and targets of translational control and in so doing provide an important historical context for readers new to this 'hot' topic. Even if you already have the previous edition of Translational Control (as I do), then that should not inhibit you from buying this new edition; it is not just an updated version of the previous editions. The editors have introduced a significant number of new topics, some of which (for example, microRNAs) were not yet on the radar in 2000. Where topics have been covered in the previous edition(s), they have succeeded in their stated aim of getting chapters that are 'stimulating, edifying and authoritative' and in several cases have used different authors to 'ring the changes'.

Genetical Research

Sequels often suffer from several shortcomings, including the monotonous repetition of ideas and the absence of the most recent advances. Readers of previous versions might have expected only a modestly updated and expanded version this time. But they are in for a surprise: all of the chapters are either substantially rewritten or are completely new and contributed by new authors. This guarantees that the book is up to date and offers fresh ideas on the future of translation research. Given the scope of this book, even the editors themselves warn that few 'will choose to read this volume from cover to cover, and certainly not in sequence.' I did, and I am glad. This book should not be missing from the shelves of any scholars of translation.

Nature Cell Biology

The new edition has been both updated and broadened. Since the previous (second) edition was published in 2000, the structures of the bacterial and eukaryotic ribosomes have been published, advancing our basic understanding of translation and mechanisms involving protein and RNA regulators. In addition, as the title indicates, this edition has a new focus on the role of translational control in human development and disease. Each reader will find out his own loved chapter . . . but all 30 chapters are an essential reading for anyone interested in the process of translation, its regulation, and how its failure can be the cause of disease.

European Journal of Histochemistry