Transdermal Drug Delivery Systems: Revised and Expanded

by Jonathan Hadgraft (Editor)

Overview

Presents authoritative state-of-the-art discussions of the key issues pertinent to transdermal drug delivery, examining those topics necessary to enable a critical evaluation of a drug candidate's potential to be delivered across the skin; from physical chemistry and assessment of drug permeability to available enhancement technolgies, to regulator

Product Details

ISBN-13:	9781135565190
Publisher:	CRC Press
Publication date:	10/29/2002
Sold by:	Barnes & Noble
Format:	eBook
Pages:	328
File size:	10 MB

About the Author

Jonathan Hadgraft

Table of Contents

Preface
Contributors
1. Feasibility Assessment in Topical and Transdennal Delivery:
Mathematical Models and In Vitro Studies
Jonathan Hadgraft and Richard H. Guy
iii
vii
2. Evaluating the Transdennal Permeability of Chemicals 25
Brent E. Vecchia and Annene L Bunge
3. Skin Absorption Databases and Predictive Equations 57
Brent E. Vecchia and Annene L Bunge
4. Partitioning of Chemicals into Skin: Results and Predictions 143
Brent E. Vecchia and Annene L Bunge
5. Iontophoresis: Applications in Drug Delivery and Noninvasive
Monitoring 199
M. Begona Delgado-Charro and Richard H. Guy
6. Skin Electroporation for Transdennal and Topical Drug
Delivery 227
Wronique Preat and Rita Vanbever
vi Contents
7. Sonophoresis: Ultrasound-Enhanced Transdennal Drug Delivery 255
Victor Meidan
8. Metabolic Approach to Transdennal Drug Delivery 285
Peter M. Elias, Kenneth R. Feingold, Janice Tsai,
Carl Thornfeldt, and Gopinathan Menon
9. The Application of Supersaturated Systems to Percutaneous
Drug Delivery 305
Mark Pellett, S. Lakshmi Raghavan, Jonathan Hadgraft, and
Adrian Davis
10. Minimally Invasive Systems for Transdennal Drug Delivery 327
James A. Down and Noel G. Harvey
11. Transdennal Drug Delivery System Regulatory Issues 361
Vinod P. Shah
Index