Total Synthesis of Bioactive Natural Products

by Goutam Brahmachari

Overview

Total Synthesis of Bioactive Natural Products provides step-by-step guidelines for effectively synthesizing the most promising bioactive agents from a broad range of natural products. Beginning with a concise background that outlines the benefits and challenges faced in effective synthesis, the book goes on to provide individual outlines for approximately 100 of the most promising bioactive agents. Taking a logical, user-friendly approach, the systematic name, compound class, structure, natural source, pharmaceutical potential and synthetic routes for each structure are detailed, with clear illustrations throughout, making this book an essential and practical guide for anyone working with both synthesis and natural products.

Product Details

ISBN-13:	9780081028223
Publisher:	Elsevier Science
Publication date:	04/27/2019
Pages:	350
Product dimensions:	6.00(w) x 9.00(h) x (d)

About the Author

Born on April 14, 1969 in Barala, a village in the district of Murshidabad (West Bengal, India), Goutam Brahmachari had his early education in his native place. He received his high school degree in scientific studies in 1986 at Barala R. D. Sen High School under the West Bengal Council of Higher Secondary Education (WBCHSE). Then he moved to Visva-Bharati (a Central University founded by Rabindranath Tagore at Santiniketan, West Bengal, India) to study chemistry at the undergraduate level. After graduating from this university in 1990, he completed his master’s in 1992 with a specialization in organic chemistry. After that, receiving his Ph.D. in 1997 in chemistry from the same university, he joined his alma mater the very next year and currently holds the position of a full professor of chemistry since 2011. The research interests of Prof. Brahmachari’s group include natural products chemistry, synthetic organic chemistry, green chemistry, and the medicinal chemistry of natural and natural product-inspired synthetic molecules. With about 23 years of experience in teaching and research, he has produced 235 scientific publications, including original research papers, review articles, books, and invited book chapters in the field of natural products and green chemistry. He has already authored/edited 26 books published by internationally reputed major publishing houses, namely, Elsevier Science (The Netherlands), Academic Press (Oxford), Wiley-VCH (Germany), Alpha Science International (Oxford), De Gruyter (Germany), World Scientific (Singapore), CRC Press (Taylor & Francis Group, USA), Royal Society of Chemistry (Cambridge), etc. Prof. Brahmachari serves as a life member for the Indian Association for the Cultivation of Science (IACS), Indian Science Congress Association (ISCA), Kolkata, and Chemical Research Society of India (CRSI), Bangalore. He has also been serving as an associate editor for Current Green Chemistry.

Prof. Brahmachari serves as the founder series editor of Elsevier Book Series’ Natural Product Drug Discovery. He is an elected fellow of the Royal Society of Chemistry, and a recipient of CRSI (Chemical Research Society of India) Bronze Medal, 2021 (contributions to research in chemistry), INSA (Indian National Science Academy) Teachers Award, 2019, Dr. Kalam Best Teaching Faculty Award, 2017, and Academic Brilliance Award, 2015 (Excellence in Research). Prof. Brahmachari was featured in the World’s Top 2% Scientists (organic chemistry category) in 2020 and 2021 and the AD Scientific Index 2022 World Ranking of Scientists, 2022.

Table of Contents

Aeruginosins 298-A and B Ageladine A (+)-Ainsliadimer A-(+) (−)-Aiphanol (+)-Amphidinolide T1 Ancistroealaine A and Ancistrotanzanine B (-)-Andrographolide Anolignan A Anolignan B Antrocamphin A Arenamide A Atroviridin Bauhinoxepin J Beta-Lapachone Bombykol Bulbophylol-B Caminoside A (+)-Chaetocin Ciliatamides A and B Cylindol A Daedalin A 6-Deoxypladienolide D 7-Desmethoxyfusarentin and its methyl ether Etnangien (+)-Gliocladin B (+)-Harziphilone Hibarimicinone (±)-3-Hydroxy-beta-ionone Hyperforin Integric acid Jineol Karalicin (-)-Kunstleramide (±)-Limonin Linderaspirone A and Bi-linderone Lucidone (±)-Marinopyrrole A Martefragin A (-)-Melotenine A Microcin SF608 Nemorosone Nicotlactone A (-)-6-O-Desmethylantofine Oleocanthal (+)3-Oxo-α-ionol Paecilomycin B Paecilomycine A Pochonin A Rhinacanthin A Rubriflordilactone A (+)-Sattazolin Somocystinamide A (-)-Stagonolide A (±)-Steenkrotin A Thiaplakortone A and its semi-synthetic derivatives Vinigrol Withaferin A Withanolide A (+)-Xylarenal A Xyolide

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From the Publisher

A detailed, step-by-step guide that supports the total synthesis of the most promising molecules from natural sources