Topics in Biomedical Gerontology available in Hardcover, eBook
Topics in Biomedical Gerontology
- ISBN-10:
- 9811021546
- ISBN-13:
- 9789811021541
- Pub. Date:
- 10/20/2016
- Publisher:
- Springer Nature Singapore
- ISBN-10:
- 9811021546
- ISBN-13:
- 9789811021541
- Pub. Date:
- 10/20/2016
- Publisher:
- Springer Nature Singapore
Topics in Biomedical Gerontology
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Overview
Aging is a global challenge to human society. Children are always in a hurry to become adults, while adults produce offspring and add to the gene pool. However, after adulthood or the attainment of reproductive maturity, all physiological parameters of the living organism start to undergo the aging process. Old age sets in slowly but surely, and usually continues for a prolonged period. If vigor and vitality are the main advantages of adulthood, old age offers the rewards of experience and maturity.
Biologists ask questions such as: Why do we age? How do we become old? Is it possible to slow down, postpone or even prevent aging? In turn, medical experts ask: What are the diseases associated with old age? Arethere medicines that can help affected elderly patients? In fact both groups are asking themselves how can we add more health to old age.
Healthy aging is the dream of every individual. But to achieve this, it is fundamental that we first understand the cellular, biochemical and molecular basis of the aging process in mammalian cells, tissues and intact living organisms, which can serve as experimental model systems in Biomedical Gerontology. Once the biology of aging is understood at the genetic and molecular levels, interventional approaches to aging and its associated diseases may be easier to plan and implement at the preclinical level.
Product Details
ISBN-13: | 9789811021541 |
---|---|
Publisher: | Springer Nature Singapore |
Publication date: | 10/20/2016 |
Edition description: | 1st ed. 2017 |
Pages: | 355 |
Product dimensions: | 6.10(w) x 9.25(h) x (d) |
About the Author
Ramesh Sharma (Ph. D., Banaras Hindu University, 1981) is a Professor at the Department of Biochemistry, North-Eastern Hill University, Shillong, India. He did his post-doctoral research at the University of California, Berkeley, USA (1986-88), and was a Visiting Professor at the Institute of Enzyme Research at Tokushima University, Japan (1989-90) and at the Department of Biochemistry at the School of Pharmaceutical Sciences, Toho University, Chiba, Japan (2003-04). He has been teaching various disciplines of physiology and biochemistry for the past 33 years, mostly at the post-graduate/research level. He has been on the editorial board of international journals such as ‘Biogerontology’ from Springer, the Netherlands; ‘International Journal of Developmental Neurosciences’ from Elsevier, USA; ‘Okinawa Wellness & Longevity Journal’ Okinawa, Japan; and ‘Frontiersin Genetics of Aging’, Science Park, Switzerland. He has produced more than 80 publications in international and national journals of repute in the field of aging research and has produced 16 Ph. D.s. In 2008, he was elected as a Fellow of the National Academy of Sciences (India). He has been the Head of the Department of Biochemistry for three terms (1993-96; 1999-2002; 2011-14) and is presently Coordinator of the UGC-SAP programme in Biochemistry and the Dean, School of Life Sciences. He has also been Coordinator of the University with Potential for Excellence (UPE) given by UGC to NEHU. He has been a member of the board of management of NERIST and a research council member of CSIR-RRL (now NEIST), Jorhat, Assam. Prof. Sharma has also been Chairman of the Board for under- and post-graduate studies in Biochemistry, Home Science and Nursing and a member of the Academic Council of NEHU and Mizoram University. He has been the President of Association of Gerontology (India) and is amember of the Task Force on Neuro-Disease Biology, DBT, GOI (2014-17). Prof. Sharma visited Semmelweis University, Budapest, Hungary (2014) under INSA-Senior Scientist Exchange Fellowship and was a Visiting Researcher at Toho University, Chiba, Japan (Jan. 01-March 31, 2016).
S. Prasad did his B. Sc. (1978, Bot., Zool., Chem.); M. Sc. (1980, Zoology with Biochemistry Specialization); Ph. D. (1988, Zoology) from the Banaras Hindu University (B.H.U.), Varanasi, India and joined as a Lecturer in 1991 and is serving at present as a Professor at the Department of Zoology, Institute of Science, B.H.U. since 2008. He worked on “Age-associated Studies on HMG Non-Histone Proteins of the Rat Liver” for his doctoral degree under the mentorship of Prof. M. K. Thakur, F.N.A.Sc., F.I.A.N. His current research interests are focused on molecular, behavioral and neurobiological mechanisms of aging as well as learning and memory during aging and diseases. He visited Royal Cancer Centre Research Institute, Tokyo under AMBO International Fellowship to work on “Genomics of Cancer” in 1991 and availed MRC Visiting Fellowship to work on “Estrogen-induced Expression of Genes in Aging Brain” with Prof. J. A. Edwardson at MRC Neurochemical Pathology Unit, New Castle General Hospital, New Castle upon Tyne, U.K. duing 1995-96. He is associated with teaching of Biochemistry & Molecular Biology, Physiology, Neuroscience, Molecular Techniques at undergraduate, postgraduate and doctoral levels in the Department of Zoology since last 26 years and Biochemistry and Neurobiology at the Department of Molecular Human Genetics until 2011. He has produced three Ph. D. students and four to submit their Ph. D. theses. He has guided and trained several postgraduate students from BHU and other universities for their dissertation work. He has been on several academic and administrative committees of the Institute of Sciences and University. He has served as member on Board of Studies for Biotechnology and Bioinformatics and Zoology at the North Eastern Hill University, Shillong, Molecular Human Genetics, Biophysics, Forensic Science and Interdisciplinary School of Life Sciences at BHU. He has published 34 research publications in journals of high impact on Aging, Molecular Biology and Neuroscience. He has written book chapters and review articles. He has edited a book on “Cellular and Molecular Neurobiology” (Narosa Publishing House, New Delhi). He is in the reviewers’ panel of many journals, e.g., Biogerontology (Springer), Neurochemistry International (Elsevier), World Journal of diabetes and ECAM (Hindawi). He has been elected as a member of the National Academy Sciences (India), Allahabad in 2010 and is associated with Association of Gerontology (India), Society of Biological Chemists, Indian society of Cell Biology, Indian Academy of Neurosciences and Society of Neurochemistry (India) as a life member and currently serving as the Secretary of Associationof Gerontology (India).
Table of Contents
1. Identification of serum sirtuins as novel non-invasive protein markers for frailty.- 2.Age-related morphological changes in the human pancreas.- 3.Changing population of neurons and glia in the human cochlear nucleus during aging.- 4.Age-related changes in the expression level of insulin-like growth factor-1 and its related signaling pathway in mice.- 5.Differential expression of arginase I and its regulation by dexamethasone in the liver of mice as a function of age.- 6.Molecular and cellular basis of memory enhancing effects ofBacopa monnieri extract on diabetes mellitus induced memory impairment in mice.- 7.Brain aging and oxidative pathology.- 8.Antiepileptic potential of dehydroepiendrosterone (DHEA).- 9.Curcumin attenuates memory impairment by modulating the expression of CamKIIα during aging.- 10.Dietary restriction, an intervention for healthy aging.- 11.Study of anti-ageing property of moringaoleifera leaves in fish brain.- 12.Alterations in the structure and functionof the chromatin during aging.- 13.Postnatal exposure of PBDE-209 impairs spatial memory in young mice:Relation of glutamate and oxidant-antioxidant homeostasis in the frontal cortex and hippocampus.- 14.Differential expression of long intergenic noncoding RNA (lincRNA) in the rat brain during aging.- 15.Dietary restriction up-regulates expression and activity of cardiac and skeletal muscle inorganic pyrophosphatase in mice as a function of age.- 16.Age-related changes in rat kidney antioxidant enzymes and oxidative stress parameters with special reference to catalase promoter methylation pattern.- 17.Recovery of age-related memory loss: hopes and challenges.- 18.Electrophysiological ageing of the brain : Ageing-related impairments in neuronal and cognitive functions.- 19.Role of autophagy in life-extension using Dictyostelium discoideum as a model system.- 20.SIRT-1: An emerging target for age-related neurodegenerative diseases.- 21.Neuroinflammation and the aging brain.- 22.Expression and regulation of Pax6 in brain of aging mice.- 23.Basic tenets of Ayurvedic Gerontology.- 24.Potential use of Ashwagandha (Withania somnifera) for alleviation of old age-associated problems.