The Third Histamine Receptor: Selective Ligands as Potential Therapeutic Agents in CNS Disorders / Edition 1

by Divya Vohora

Overview

Reveals an Emerging Avenue of Potential Treatments for a Host of Challenging Diseases and Disorders

The H₃ receptor is known to play a major role in a range of CNS disorders, including those affecting cognitive functions such as ADHD and Alzheimer’s disease, as well as sleep disorders, obesity, epilepsy, schizophrenia, depression, and neurodegeneration. In light of dramatic advances in research at the molecular level, supported by impressive clinical studies, optimism remains high that an H₃ receptor-related drug could hit the market soon.

The Third Histamine Receptor: Selective Ligands as Potential Therapeutic Agents in CNS Disorders provides a thorough grounding in advances made over the last two decades. It brings together an elite group of 30 pioneering researchers. In writing about their own work, these scientists report on the cutting-edge investigations that are now being conducted across a variety of disciplines. This text is designed to aid researchers and inform those involved in the treatment and clinical aspects of a number of histamine-related diseases.

Presents Several Disease-Specific Chapters

Certainly, the most comprehensive and cutting-edge volume in the field, this text includes material drawn from groundbreaking research techniques and patent literature. Put together with great thought and passion, it is written to serve as a primary resource for anyone involved with or interested in the identification and localization of H₃ receptors and the ligands being developed as therapeutic agents to treat a wide range of diseases including some that were once considered intractable.

Product Details

ISBN-13:	9780367452513
Publisher:	CRC Press
Publication date:	12/16/2019
Pages:	406
Product dimensions:	6.12(w) x 9.19(h) x (d)

Table of Contents

INTRODUCTION. H3 Receptor Target: Past, Present, and Future Perspectives from Worldwide H3 Experts. The Third Histamine Receptor: From Discovery to Clinics, a Long- Lasting Love Story at INSERM and Bioprojet. Histamine as a Neurotransmitter. THE THIRD HISTAMINE RECEPTOR. Phylogeny, Gene Structure, Expression, and Signaling. Drug Discovery: From Hits to Clinical Candidates. Peripheral Actions and Therapeutic Potential in Periphery. THERAPEUTIC POTENTIAL IN CENTRAL NERVOUS SYSTEM DISORDERS. Cognitive Functions, Attention-Deficit Hyperactivity Disorders, and Alzheimer’s Disease. Sleep Disorders. Obesity. Epilepsy. Schizophrenia. Other Central Nervous System Disorders.

What People are Saying About This

From the Publisher

… this book offers a key overview of the subject, useful not only to mature researchers but also all scientists who discover this field. … will certainly become a work of reference in this rapidly-growing domain.
—Dr. Laurent Provins, UCB Pharma (Belgium), in ChemMedChem 2009

Editorial Reviews

… this book offers a key overview of the subject, useful not only to mature researchers but also all scientists who discover this field. … will certainly become a work of reference in this rapidly-growing domain.
—Dr. Laurent Provins, UCB Pharma (Belgium), in ChemMedChem 2009

From the Publisher